Raised cardiac troponin T levels in patients without acute coronary syndrome

Abstract

Patients without ACS but with raised levels of troponin T comprised 38% of all hospitalised patients found to have raised troponin T. These patients had worse in-hospital and 6-month outcome than those having ACS with raised levels of troponin T.

The Etiology and Prognostic Significance of Cardiac Troponin I Elevation in Unselected Emergency Department Patients

“…The proportion of non-MI patients was somewhat lower in our ED patient cohort compared to that observed by Wong et al (38%) and by Alcalai et al (41%) (4,5). These studies included all patients with elevated cTn measured during hospitalization as we focused on cTn positivity observed at admission and shortly thereafter.…”

Achieving biosensing at attomolar concentrations of cardiac troponin T in human biofluids by developing a label-free nanoplasmonic analytical assay

“…Furthermore, we also show that our chip-based fabrication methodology is highly reproducible in which biosensors fabricated six months apart (batch-to-batch variation) produced nearly identical sensitivity. Owing to the enormous importance of cTnT in human health where >10 ng/L level is considered to be high risk for Myocardial Infarction (MCI), [26][27][28][29][30][31][32][33][34][35] we expect that our simple, cost-effective, and ultrasensitive assay in real human biofluids will be capable of detecting the potentially minute change in cTnT concentrations in symptom-free (chest, back, or jaw pain, and stable coronary artery disease) and poorly differentiated cases and allow interpretation to prevent heart attack by early diagnosis, thereby greatly improving patient survival. 36 Finally, our determination of the most influential nanoscale structural parameters and our methodology to control surface functionalization and immobilization of receptors will provide experimental benchmarks for the fabrication of ultrasensitive biosensors to quantitatively study a variety of important protein-protein interactions.…”

Validation of a prediction score model to distinguish acute coronary syndromes from other conditions causing raised cardiac troponin T levels

“…Methods for group 1 have been described elsewhere [10] and were adopted for this study. In brief, group 1 (5 January 2004 to 29 February 2004) and group 2 (1 January 2006 to 28 February 2006) consisted of consecutive patients who were admitted to a university hospital emergency department and were found to have a detectable level of troponin T (Z 0.01 mg/l).…”