Raised ?2-Microglobulin as a Surrogate Marker in Non-Secretory Multiple Myeloma

Abstract

Abstract:Multiple myeloma is a neoplasm of plasma cells in the bone marrow. It is characterised by lytic lesions in the bones, marrow plasmacytosis and presence of M protein in serum and/or urine. Serum β2 microglobulin is also raised and can be used for classification and prognostication of the disease. In the absence of M protein, the disease is known as non-secretory myeloma. It is proposed that raised β2 microglobulin can be used for diagnosis and therapeutic guidance in the absence of M protein. A rare case of nonsecretory myeloma with neurocognitive impairment along with review of literature is being presented. The patient had multiple lytic lesions in bones with marked increase in plasma cells in bone marrow. M protein was not detectable in serum or urine but serum β2 microglobulin was much elevated.

Backache could be an indication of multiple myeloma: An unusual case report

“…In the literature, many case reports and research articles have described the diagnostic signs and symptoms of MM i.e. nausea, constipation, loss of appetite, fatigue, weight loss, arthralgia, lytic bone lesions, myalgia, renal problems, hypercalcemia, liver and spleen related symptoms, etc 1 . The interesting finding in the current case report is that the patient presented with the complaint of chronic backache only which was mild to moderate in intensity.…”

“…Multiple myeloma is a neoplasm of plasma cells in the bone marrow. It is characterized by lytic lesions in the bones, marrow plasmacytosis and presence of M protein in serum and/or urine.MM accounts for 1 % of human cancers, almost 2 % of cancer deaths and 12-15% of all hematological cancers 1,2 . This can be detected by monoclonal protein in the blood or urine, and dysfunction of associated organs.…”