Rainbow trout estrogen receptor presents an equal specificity but a differential sensitivity for estrogens than human estrogen receptor

Dréan, Yves Le; Kern, Laurence; Pakdel, Farzad; Valotaire, Yves

doi:10.1016/0303-7207(95)03482-m

Cited by 78 publications

(44 citation statements)

References 46 publications

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“…The ligands used here are agonists which promote the ERa binding to coactivators and antagonists which are able to inhibit these intermolecular interactions and/or promote interactions with corepressors [42][43][44]. The main results of this in cellulo study are: (i) in the absence of ligand, rtERa S is able to activate gene transcription whereas hERa does not activate, or very poorly, as previously observed in other yeast strains as well as in mammalian cells [22,[24][25][26][27]45,46]; (ii) rtERa S is less efficient in response to ligands than hERa. In our unique cellular system, E2 and DES are equally efficient and potent agonists of hERa and rtERa S .…”

Section: Discussionsupporting

confidence: 56%

Investigation of the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors within a unique yeast cellular context

Grand

Bouter

Couturier

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionsupporting

confidence: 56%

Investigation of the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors within a unique yeast cellular context

Grand

Bouter

Couturier

et al. 2015

The Journal of Steroid Biochemistry and Molecular Biology

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“…Nuclear hormone receptors exhibit a sequential organization into consecutive domains enumerated A to F. These have highly specific functions: domains A and B are required for ligand-independent transactivation; domain C, with its two zinc-fingers, for DNA-binding; and domain E for ligand-dependent transactivation, dimerization, and interaction with other proteins (162). The sequence of the ER gene is conserved in all species studied except fish (163). In fish, only the C and E domains have high homology to ERs of other species.…”

Section: Nuclear Receptor Superfamilymentioning

confidence: 99%

The Hair Follicle as an Estrogen Target and Source

et al. 2006

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For many decades, androgens have dominated endocrine research in hair growth control. Androgen metabolism and the androgen receptor currently are the key targets for systemic, pharmacological hair growth control in clinical medicine. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs). Besides altering the transcription of genes with estrogen-responsive elements, 17␤-estradiol (E2) also modifies androgen metabolism within distinct subunits of the pilosebaceous unit (i.e., hair follicle and sebaceous gland). The latter displays prominent aromatase activity, the key enzyme for androgen conversion to E2, and is both an estrogen source and target.Here, we chart the recent renaissance of estrogen research in hair research; explain why the hair follicle offers an ideal, clinically relevant test system for studying the role of sex steroids, their receptors, and interactions in neuroectodermal-mesodermal interaction systems in general; and illustrate how it can be exploited to identify novel functions and signaling cross talks of ER-mediated signaling. Emphasizing the long-underestimated complexity and species-, gender-, and site-dependence of E2-induced biological effects on the hair follicle, we explore targets for pharmacological intervention in clinically relevant hair cycle manipulation, ranging from androgenetic alopecia and hirsutism via telogen effluvium to chemotherapy-induced alopecia. While defining major open questions, unsolved clinical challenges, and particularly promising research avenues in this area, we argue that the time has come to pay estrogen-mediated signaling the full attention it deserves in future endocrinological therapy of common hair growth disorders. (Endocrine Reviews 27: 677-706, 2006)

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“…The actions of estrogen are mainly mediated by estrogen receptors (ERs), which belong to the nuclear receptor superfamily (Laudet et al 1992;Mangelsdorf et al 1995). As ligand-activated transcription factors (Kuiper et al 1996), ERs are able to regulate transcription of target genes through binding to estrogen responsive elements in the promoter region of the target gene (Le Dréan et al 1995;Klinge 2000) and consequently evoke estrogenic responses.…”

mentioning

confidence: 99%

Distinct expression of three estrogen receptors in response to bisphenol A and nonylphenol in male Nile tilapias (Oreochromis niloticus)

Huang

Jia²,

et al. 2008

Fish Physiol Biochem

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Environmental estrogens, such as bisphenol A (BisA) and nonylphenol (NP), have been shown to affect the estrogen receptor (ER) expression and induce male reproductive abnormalities. To elucidate molecular mechanisms of action of xenoestrogenic chemicals on the expression of estrogen receptors in the testes of Nile tilapia (Oreochromis niloticus), three full-length cDNAs respectively encoding ntERalpha, ntERbeta1 and ntERbeta2 were cloned from testes. The amino acid sequences of ntERalpha, ntERbeta1 and ntERbeta2 showed a high degree of similarity to the relevant fish species. Tissue-specific expression study showed that three receptors were highly expressed in pituitary, liver, testis, kidney and intestine tissues. The ntERalpha, ntERbeta1 and ntERbeta2 mRNA expressions were significantly higher at the sexual early recrudescing stage than at other recrudesced stages. After being exposed to xenoestrogens from weeks 2 to 4, the ntERalpha mRNA levels were increased significantly in testes after NP treatment at all sampling times or after 4 weeks of exposure to BPA. The ntERbeta1 mRNA levels remained unchanged, while a significant decrease of the ntERbeta2 mRNA level was observed in testes after exposure to NP and BPA. The present study demonstrates that the regulation of all three ntER subtypes in testes may act via different molecular mechanisms of exposure to NP and BPA.

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Rainbow trout estrogen receptor presents an equal specificity but a differential sensitivity for estrogens than human estrogen receptor

Cited by 78 publications

References 46 publications

Investigation of the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors within a unique yeast cellular context

Investigation of the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors within a unique yeast cellular context

The Hair Follicle as an Estrogen Target and Source

Distinct expression of three estrogen receptors in response to bisphenol A and nonylphenol in male Nile tilapias (Oreochromis niloticus)

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