RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP

Crombruggen, Koen Van; Holtappels, Gabriële; Ruyck, Natalie De; Derycke, Lara; Tomassen, Peter; Bachert, Claus

doi:10.1016/j.jaci.2012.02.021

Cited by 27 publications

(20 citation statements)

References 45 publications

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“…Our findings are consistent with those of Ferhani et al who found elevated RAGE level in the lung tissue of patients with chronic obstructive pulmonary disease (COPD) [30]. It was reported by Crombruggen et al that RAGE was expressed in the human upper airways under normal physiological conditions [14]. In their CRSsNP tissue, the tissue levels of the soluble RAGE (sRAGE) protein fraction was significantly higher compared to normal tissue, while conversely, the mRAGE (membrane-bound RAGE) levels were significantly lower compared to normal tissue.…”

Section: Discussionsupporting

confidence: 93%

“…Surprisingly, cytology results, asthma or NSAIDs also did not affect RAGE expression. We also observed that a positive microbiological status of the nasal cavity correlated with higher RAGE expression which is consistent with study of Crombruggen [14], however, in our study there was no evident correlation between specific microbes and RAGE expression.…”

Section: Discussionsupporting

confidence: 92%

“…In their CRSsNP tissue, the tissue levels of the soluble RAGE (sRAGE) protein fraction was significantly higher compared to normal tissue, while conversely, the mRAGE (membrane-bound RAGE) levels were significantly lower compared to normal tissue. These authors hypothesized that the decrease of mRAGE protein observed in pathologic conditions was likely to be mediated via the cleavage of mRAGE by deregulated metalloproteinase activity to form sRAGE that subsequently binds cellular and extracellular matrix components [14]. Since in our study we used antibody which recognized both mRAGE and sRAGE we were unable to distinguish precisely both forms of this receptor.…”

Section: Discussionmentioning

confidence: 82%

“…sRAGE derived via alternative mRNA splicing is known as esRAGE (endogenous secretory RAGE' or RAGE_v1), whereas sRAGE derived from the proteolytic cleavage of mRAGE is referred to as cleaved RAGE (cRAGE). The soluble sRAGE form is present in the in the extracellular space and can bind RAGE ligands in the circulation [14,15].…”

Section: Introductionmentioning

confidence: 99%

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High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Dżaman

Zagor

Molińska-Glura

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Chronic rhinosinusitis (CRS) affects 14% of the world population. The high motility group box 1 (HMGB1) protein triggers inflammation, cell proliferation and cell survival through its receptor for advanced glycation end products (RAGE) upon release from stressed or necrotic cells. The aim of the study was to analyze the expression and function of HMGB1 and RAGE in CRS, providing more information about HMGB1 signaling pathway in CRS, to determine its potential clinical significance. Material and methods. Thirty-seven patients with CRS and 26 normal controls (NC) were enrolled in this study. Classification of disease severity using the SNOT-20 questionnaire, nasal endoscopy, CT scan, assessment of allergy status, microbiological and cytological analysis was performed in patients. Fresh sinus mucosa samples were obtained and analyzed by immunohistochemistry for HMGB1 and RAGE expression in epithelial cells. ELISA assay was performed to evaluate the concentration of HMGB1 in the patients' sera. Results. No differences were found in HMGB1 immunoexpression between CRS patients and NC, however there was a highly significant difference in RAGE immunoexpression between both groups. There was a correlation between RAGE expression and number of tissue-infiltrating lymphocytes. Further, RAGE expression positively correlated with disease severity and a positive history for allergies. Conclusions. Interaction of HMGB1 and RAGE might be relevant to CRS pathomechanisms leading to sinus mucosa hyperproliferation. CRS pathogenesis might be especially related to the RAGE overexpression correlated with disease severity and allergy.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Dżaman

Zagor

Molińska-Glura

et al. 2015

Folia Histochem Cytobiol.

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“…Van Crombruggen et al 487 examined the receptor for advanced glycation end products (RAGE) in CRSsNP and controls. They found sinus mucosal protein levels of the soluble form of RAGE to be elevated in CRS, whereas the membrane form was decreased.…”

Section: S63mentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Chronic rhinosinusitis: assessment of changes in nociceptive neurons

Bogaert

Crombruggen

Holtappels

et al. 2020

Int Forum Allergy Rhinol

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Background: Pain is a major symptom of chronic rhinosinusitis (CRS). It is mainly associated with CRS without nasal polyps (CRSsNP) and has a major impact in the decision to move on to surgery. Patients with CRS with nasal polyps (CRSwNP) are characterized by trigeminal hypoesthesia and suffer from less pain. The aim of this study was to investigate whether CRS induces alterations in the peripheral nociceptive neurons, mainly focusing on quantitative changes. Methods: Sinus mucosa and inferior turbinate (IT) samples were obtained from patients with CRS, and IT tissue of healthy patients served as controls. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was performed for neuronal markers including CNTNAP2,

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RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP

Cited by 27 publications

References 45 publications

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Chronic rhinosinusitis: assessment of changes in nociceptive neurons

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