Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis

Odabaei, Golaun; Chatterjee, Devasis; Jazirehi, Ali R.; Goodglick, Lee; Yeung, Kam C.; Bonavida, Benjamin

doi:10.1016/s0065-230x(04)91005-6

Cited by 162 publications

(139 citation statements)

References 64 publications

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“…Rkip is a multifunctional protein involved in diverse processes, including tumor suppression, cell cycle regulation, and Raf-1/MAPK signaling cascade (48). Inhibition of Rkip results in increased cell proliferation by affecting spindle checkpoint, resulting in chromosomal aberrations and cancer progression (43).…”

Section: Discussionmentioning

confidence: 99%

Accumulation of the Raf-1 Kinase Inhibitory Protein (Rkip) Is Associated with Cep290-mediated Photoreceptor Degeneration in Ciliopathies

Murga‐Zamalloa

Ghosh

Patil

et al. 2011

Journal of Biological Chemistry

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Primary cilia regulate polarized protein trafficking in photoreceptors, which are dynamic and highly compartmentalized sensory neurons of retina. The ciliary protein Cep290 modulates cilia formation and is frequently mutated in syndromic and non-syndromic photoreceptor degeneration. However, the underlying mechanism of associated retinopathy is unclear. Using the Cep290 mutant mouse rd16 (retinal degeneration 16), we show that Cep290-mediated photoreceptor degeneration is associated with aberrant accumulation of its novel interacting partner Rkip (Raf-1 kinase inhibitory protein). This effect is phenocopied by morpholino-mediated depletion of cep290 in zebrafish. We further demonstrate that ectopic accumulation of Rkip leads to defective cilia formation in zebrafish and cultured cells, an effect mediated by its interaction with the ciliary GTPase Rab8A. Our data suggest that Rkip prevents cilia formation and is associated with Cep290-mediated photoreceptor degeneration. Furthermore, our results indicate that preventing accumulation of Rkip could potentially ameliorate such degeneration.

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Section: Discussionmentioning

confidence: 99%

Accumulation of the Raf-1 Kinase Inhibitory Protein (Rkip) Is Associated with Cep290-mediated Photoreceptor Degeneration in Ciliopathies

Murga‐Zamalloa

Ghosh

Patil

et al. 2011

Journal of Biological Chemistry

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“…Raf is the upstream pawn of this evolutionarily conserved pathway comprising the sequential activities of three protein kinases: RAF, MEK, and ERK. This signaling pathway is able to transmit extracellular signals into nuclear instructions, particularly those with cellular survival meaning against apoptosis [72]; RKIP is a member of the phosphatidylethanolamine binding proteins shown to disrupt RAF/MEK/ERK signaling pathway [73], thanks to its physical interaction with RAF. RKIP has thereby a proapoptotic function, and the upregulation demonstrated in our proteomic study is another brick put for the apoptotic hypothesis (Fig.…”

Section: Omic Clues Towards Apoptosismentioning

confidence: 99%

Apoptosis in muscle-to-meat aging process: The omic witness

Longo

Lana

Bottero

et al. 2015

Journal of Proteomics

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“…75,76 RKIP has been subsequently shown to interact with other proteins (for example, nuclear factor-binding immunoglublin-k chain enhancer in B cells and inhibitory kB kinase) and be regulated by other proteins (for example, Snail), which are involved in regulation of the epithelial-mesenchymal transition. 77,78 RKIP can also antagonize nuclear factor-binding immunoglublin-k chain enhancer in B cell activation in response to tumor necrosis factor-1 and interleukin-1b stimulation. [78][79][80] RKIP expression is characterized as a metastasissuppressor protein.…”

Section: Flt3 Mutations and Leukemia Therapymentioning

confidence: 99%