Radon and Lung Cancer in the American Cancer Society Cohort

Turner, Michelle C.; Krewski, Daniel; Chen, Yue; Pope, C. Arden; Gapstur, Susan M.; Thun, Michael J.

doi:10.1158/1055-9965.epi-10-1153

Cited by 100 publications

(90 citation statements)

References 45 publications

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“…Also, we used the different method for dose-response analysis based on widely accepted method in STATA software (Greenland and Longnecker, 1992). Furthermore, our result is in agreement with the recent USA cohort study where a significant positive linear trend was observed between categories of radon concentrations and lung cancer mortality (Turner et al, 2011). Although DOI:http://dx.doi.org/10.7314/APJCP.2012.13.6.2459 Residential Radon andLung Cancer Risk: An Updated Meta-analysis of Case-control Studies cohort study is more effective than case-control study, it was not included in this meta-analysis since they belong to different study designs.…”

Section: Discussionsupporting

confidence: 87%

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Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Zhang¹,

Sun²,

Dong³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results. Methods: We therefore performed a meta-analysis of relevant published casecontrol studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed-or random-effects models. Subgroup and dose-response analyses were also performed. Results: We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/m 3 increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer. Conclusions: This metaanalysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.

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Section: Discussionsupporting

confidence: 87%

“…Among the case-control studies included in the present meta-analysis, only the Thompson study (2008) showed a striking protective or hormetic effect on lung cancer at low radon exposure. And it is consented that to reduce residential radon to the lowest possible level would be beneficial anyhow (Turner et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Zhang¹,

Sun²,

Dong³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Radon gas is formed during the radioactive decay of uranium-238 (2, 18,19). Radon is regarded as an independent risk factor for LC (16).…”

Section: Risk Factorsmentioning

confidence: 99%

Epidemiology, risk factors, symptomatology, TNM classification of Non Small Cell Lung Cancer. An overview while waiting the 8^th TNM classification

Grapatsas¹,

Leivaditis²,

Tsilogianni³

et al. 2017

Oncomedicine

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Lung cancer is a primary health issue which preoccupies the health professional community worldwide. Lung cancer is one of the leading causes of death in both men and women in the developed countries. It is mainly divided into two types. The non small cell lung cancer (NSCLC) and the small cell lung cancer (SCLC). The NSCLC is the most common type and consists the 87% of lung cancer overall. The staging and the therapeutic approach of NSCLC is based on TNM classification system. Currently the 7 th revision is being used for the appropriate classification of the cancer stadium. By the end of 2016 a new 8 th TNM classification is awaited.

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“…Both studies were based on individual measurements (for each dwelling) of residential radon, unlike the studies having the same design and shown in Table 4 15,16,17 . In most of the latter studies, radon concentrations were obtained by estimation using mathematical models, or had measures that were directly attributable to the mean concentrations of radon in the participants' county of residence, whereas in our study, individualized radon concentrations were obtained for each dwelling 9,15,16,17 .…”

Section: Initial Cohort Cases N (%) N (%)mentioning

confidence: 99%

Residential radon and lung cancer: a cohort study in Galicia, Spain

et al. 2017

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Case-control studies show an association between residential radon and lung cancer. The aim of this paper is to investigate this association through a cohort study. We designed an ambispective cohort study using the Galician radon map, Spain, with controls drawn from a previous case-control study. Subjects were recruited between 2002 and 2009. The data were cross-checked to ascertain lung cancer incidence and then analysed using a Cox regression model. A total of 2,127 subjects participated; 24 lung cancer cases were identified; 76.6% of subjects were drawn from the radon map. The adjusted hazard ratio was for the category of subjects exposed to 50Bq/m 3 or more. This risk rose when subjects from the case-control study were analyzed separately. In conclusion, we did not observe any statistically significant association between residential radon exposure and lung cancer; however, it appears that with a sample of greater median age (such as participants from the case-control study), the risk of lung cancer would have been higher.

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Radon and Lung Cancer in the American Cancer Society Cohort

Cited by 100 publications

References 45 publications

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Epidemiology, risk factors, symptomatology, TNM classification of Non Small Cell Lung Cancer. An overview while waiting the 8^th TNM classification

Residential radon and lung cancer: a cohort study in Galicia, Spain

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Radon and Lung Cancer in the American Cancer Society Cohort

Cited by 100 publications

References 45 publications

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Residential Radon and Lung Cancer Risk: An Updated Meta-analysis of Case-control Studies

Epidemiology, risk factors, symptomatology, TNM classification of Non Small Cell Lung Cancer. An overview while waiting the 8th TNM classification

Residential radon and lung cancer: a cohort study in Galicia, Spain

Contact Info

Product

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Epidemiology, risk factors, symptomatology, TNM classification of Non Small Cell Lung Cancer. An overview while waiting the 8^th TNM classification