2011
DOI: 10.1152/ajpheart.01157.2010
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Radius-dependent decline of performance in isolated cardiac muscle does not reflect inadequacy of diffusive oxygen supply

Abstract: The study of cardiac energetics commonly involves the use of isolated muscle preparations (papillary muscles or trabeculae carneae). Their contractile performance has been observed to vary inversely with thickness. This inverse dependence has been attributed, almost without exception, to inadequate diffusion of oxygen into the centers of muscles of large diameter. It is thus commonly hypothesized that the radius-dependent diminution of performance reflects the development of an anoxic core. We tested this hypo… Show more

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Cited by 31 publications
(33 citation statements)
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References 100 publications
(136 reference statements)
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“…Trabeculae ( n = 15) of sufficiently small diameter (0.22 ± 0.02 mm) were used to obviate the risk of diffusion‐limited delivery of molecular oxygen to their central cores (Han et al . ). In the calorimeter, the trabecula was superfused with normal Tyrode solution (composition as listed above except for a higher concentration of CaCl 2 : 1.5 mmol l −1 and without 2,3‐butanedione monoxime).…”
Section: Methodsmentioning
confidence: 97%
“…Trabeculae ( n = 15) of sufficiently small diameter (0.22 ± 0.02 mm) were used to obviate the risk of diffusion‐limited delivery of molecular oxygen to their central cores (Han et al . ). In the calorimeter, the trabecula was superfused with normal Tyrode solution (composition as listed above except for a higher concentration of CaCl 2 : 1.5 mmol l −1 and without 2,3‐butanedione monoxime).…”
Section: Methodsmentioning
confidence: 97%
“…The rate of flow of superfusate was 0.5 μl s −1 . Despite this low flow rate, preparations were predicted to have been adequately supplied with oxygen via diffusion (Han et al . 2011).…”
Section: Methodsmentioning
confidence: 99%
“…Trabeculae are characterized by linearly arranged myocytes, thereby rendering measurements of both passive and active force development relatively unambiguous. Their second virtue is their diameter – sufficiently small to render unlikely the development of anoxic cores, even under high rates of metabolic demand (Han et al . 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Because of the linear arrangement of their myocytes, trabeculae are ideal for mechanical measurements (135). Because of their small radii, trabeculae superfused with oxygenated saline solutions are unlikely to experience oxygen diffusion insufficiency, even at high rates of stimulation (63). The design of the "Amsterdam calorimeter" was conceptually simple: hexagonal upstream and downstream arrays of thermocouples were embedded in the walls of an acrylic tube of inside diameter 0.8 mm.…”
Section: Cardiac Muscle Myometrymentioning
confidence: 99%