Radiotherapy on hidradenocarcinoma

Abstract

Context:Clear cell Hidradenocarcinoma is a rare carcinoma arising from sweat glands. It is an aggressive tumor that most metastasizes to regional lymph nodes and distant viscera; surgery with safe margins is the mainstay of treatment.Case Report:We report a case of 68-year-old woman who presented with an invasive clear cell hidradenocarcinoma situated in the left parotid area which recurred 5 months after surgery, this recurrence was managed successfully by high-dose irradiation of the tumor bed (66 Gy) and regional lymphatic chains (50 Gy), after a follow-up of more than 15 months, the patient is in good local control without significant toxicity.Conclusion:Post operative radiotherapy allows better local control and should be mandatory when histological features predictive of recurrence are present: positive margins, histology poorly differentiated, perineural invasion, vascular and lymphatic invasion, lymph node involvement, and extracapsular spread.

Managing a Rare Malignant Sweat Gland Tumor Invading the Brain: Case Report and Literature Review

“…Though most of the CCH are denovo tumours, they can rarely arise from progression in pre-existing hidradenoma 6 .…”

Hidradenocarcinoma of scalp: a case report and review of literature

“…The tumour usually arises conventionally de novo or rarely hidradenocarcinoma may arise from pre-existing hidradenoma. 8 If the diagnosis of hidradenocarcinoma is made, then it is advisable to undergo a whole body scan to exclude distant metastasis, as the distant metastasis is more common in these tumors.…”

“…13 In contrary a case report by Lalya et al, they have concluded that adjuvant therapy should be considered postoperatively for improved loco-regional control and should be mandatory in certain histopathological features like dermal lymphatic invasion, perineural invasion, high anaplastic morphology, extracapsular lymph nodal extension, infiltration of deep structures and positive surgical margins. 8 Their patient was initially treated with only surgery and had recurrence within 5 months of surgery and this recurrence was managed successfully by high dose radiotherapy. Harari and colleagues reported complete remissions with external beam radiotherapy of sweat gland tumours with positive margins after surgery.…”

Clear Cell Hidradenocarcinoma of the Scalp: An Unusual Case of Sweet Gland´S Tumor

“…Radiotherapy is used as an adjuvant treatment in the adjustment of the tumors with positive margins, in the complete resection of large tumors, recurrent and with an invasion to the lymph nodes [19,20].…”