Radiotherapy of intracranial germinomas

Huh, Seung Jae; Shin, Kyung Hwan; Kim, Il-man; Ahn, Yong Chan; Ha, Sung Whan; Park, Charn Il

doi:10.1016/0167-8140(95)01649-x

Cited by 78 publications

(39 citation statements)

References 39 publications

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“…Longterm outcomes, including relapse and the side effects of radiotherapy, must be assessed to standardize the treatment of germinomas with dissemination at the initial diagnosis. 8) …”

Section: Discussionmentioning

confidence: 99%

“…9,24) Additionally, spinal dissemination at diagnosis is rare because the most prevalent locations are intracranial, and dissemination is usually identified using cerebrospinal fluid (CSF) cytology. 6,8,11) We describe an unusual case of a pineal pure germinoma that showed spinal dissemination at initial diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Multiple or disseminated lesions, including synchronous lesions in the pineal and suprasellar regions, are relatively rare, occurring in only 6-15% and 4-9% of whole germ cell tumors, respectively. 7,8,11,16,18,21) Multiple or disseminated lesions generally have a poorer prognosis than solitary lesions because of the higher recurrence rate. 1,7) Dissemination is usually seen at recurrence after treatment or during the development of nongerminomatous tumors.…”

Section: Introductionmentioning

confidence: 99%

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Pure Germinoma of the Pineal Gland With Synchronous Spinal Dissemination -Case Report-

Nagaishi

Suzuki

Tanaka

et al. 2010

Neurol. Med. Chir.(Tokyo)

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An 11-year-old boy presented with pineal pure germinoma with spinal dissemination manifesting as a 1-month history of ocular motility disturbance and a history of abnormal sensations in the left leg persisting for several months. His past medical history was unremarkable. Craniospinal magnetic resonance imaging showed an enhanced tumor in the pineal gland and widespread leptomeningeal dissemination in the spinal canal. Biopsy of the pineal tumor was performed. Histological examination revealed a pure germinoma. Chemotherapy with carboplatin and etoposide in combination with radiotherapy induced complete remission of the tumors. He regained normal eye movement and sensation in his left leg during the chemotherapy period. Germinomas with dissemination are generally more malignant and refractory than solitary germinomas, but this patient showed a strong response to chemoradiotherapy.

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“…Longterm outcomes, including relapse and the side effects of radiotherapy, must be assessed to standardize the treatment of germinomas with dissemination at the initial diagnosis. 8) …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pure Germinoma of the Pineal Gland With Synchronous Spinal Dissemination -Case Report-

Nagaishi

Suzuki

Tanaka

et al. 2010

Neurol. Med. Chir.(Tokyo)

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“…Doses of primary site irradiation in most series have ranged between 4,000 and 5,500 cGy [32][33][34][35][36][37][38][39][40][41]. Some studies have suggested poorer survival if doses lower than 4,000 cGy of radiation are delivered to the primary site [1,40] (Table 3).…”

Section: Management: Germinomasmentioning

confidence: 99%

Intracranial Germ Cell Tumors

Takakura¹

1998

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Intracranial germ cell tumors are a heterogeneous group of lesions which occur in children and adults. Within the classification of intracranial germ cell tumors, there are a variety of different tumor types which carry different prognoses. The diagnosis of an intracranial germ cell tumor usually requires histological information, but a subgroup of tumors will secrete specific tumor markers, including α-fetoprotein and β-human chorionic gonadotropin, which may obviate the need for surgical intervention.The management of intracranial germ cell tumors in both children and adults remains unsettled. Germinomas have a good prognosis, as over 90% of patients can be effectively treated with radiation therapy. The dose and volume of radiation therapy needed for disease control is not well established, and controversy exists concerning the need for whole brain or craniospinal radiation therapy for localized tumors. Germinomas are also chemosensitive and recent reports suggest that the dose and volume of radiation therapy required for disease control can be lessened with the addition of adjuvant chemotherapy.The outcome for patients with nongerminomatous germ cell tumors is less favorable. Radiation therapy alone will result in disease control in 40%-60% of patients. The addition of chemotherapy to radiation therapy may improve the rate of survival. The Oncologist 2000;5:312-320

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“…[4][5][6] Compared with the germinomas in other locations, the typical image finding of BG germinoma is the relatively large tumor size with a mild space-occupying effect 7,8 ; and cystic formation, calcification, and intratumoral bleeding are commonly seen. 1 Because germinomas are highly sensitive to radiation therapy (RT), which can achieve a curable outcome without surgical intervention, 9 early diagnosis is important for treatment and prognosis. Conventional MR imaging, including T1-weighted images (T1WI), T2-weighted images (T2WI), and postgadolinium T1WI sequences, has been a valuable tool in the diagnosis of BG germinomas.…”

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confidence: 99%