Radiotherapy-induced thyroid disorders

Jereczek‐Fossa, Barbara Alicja; Alterio, Daniela; Jassem, Jacek; Gibelli, Bianca; Tradati, Nicoletta; Orecchia, Roberto

doi:10.1016/j.ctrv.2003.12.003

Cited by 237 publications

(219 citation statements)

References 133 publications

Supporting

Mentioning

208

Contrasting

Unclassified

Order By: Relevance

“…Thyroid investigations in patients with hematological disorders have essentially focused on the thyroid complications ensuing from chemotherapy and/or external irradiation (4)(5)(6)(7)(8)(9)(10)14,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Because no study has simultaneously taken care of all clinically relevant thyroid aspects (namely, function, autoimmunity and nodules), we have conducted such a study on hematoncologic patients excluding those who had been treated with external irradiation.…”

Section: Introductionmentioning

confidence: 99%

“…Among side effects of IMIDs and TKIs, alteration of thyroid function and triggering of thyroid autoimmunity has been reported (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Side effects on the thyroid caused by head and neck radiotherapy include altered function and development of nodules that are at greater risk of being malignant (14). Thyroid lymphomas are rare malignancies and so are thyroid plasmacytomas (15).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid function, autoimmunity and nodules in hematological malignancies

Mondello

Sindoni

Pitini

et al. 2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objective: Hematological malignancies encompass a large spectrum of disease entities whose treatment by chemo/radiotherapy could lead to thyroid complications. To the best of our knowledge, no study has simultaneously addressed thyroid function, autoimmunity and nodularity. Therefore, we decided to conduct one. Materials and methods: We evaluated 82 Caucasian patients (36 women and 46 men), who were treated at our Oncology division for hematological malignancies (multiple myeloma, chronic myeloid leukemia, chronic lymphatic leukemia, non-Hodgkin lymphoma and polycythemia vera) and compared them with a control group of 104 patients. Patients who had received or were receiving external head/neck radiotherapy were excluded. All oncological patients and control individuals underwent thyroid ultrasonography and thyroid function and autoimmunity tests. Results: A lower prevalence of enlarged thyroid and nodules were found in patients with respect to controls. The rate of thyroid nodules was the highest in multiple myeloma and polycythemia vera, and the lowest in chronic lymphatic leukemia. Non-Hodgkin lymphoma patients had the smallest thyroid nodules while men with multiple myeloma the biggest ones. No patient had hypothyroidism, while 5.6% of patients had subclinical hyperthyroidism. In contrast, within the control group the rates of hypothyroidism and hyperthyroidism, overt and subclinical, were 3.8%, 20.2%, 0% and 0% respectively. Moreover, the overall rate of thyroid autoantibody positiveness in patients was significantly lower than controls. Conclusion: In our experience, we found a significantly lower prevalence of thyroid abnormalities in hematologic patients who underwent chemotherapy, but not radiotherapy, with respect to controls. Arch Endocrinol Metab. 2015;59(3):236-44

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thyroid function, autoimmunity and nodules in hematological malignancies

Mondello

Sindoni

Pitini

et al. 2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

show abstract

“…In contrast to hypothyroidism, the frequency of hyperthyroidism due to Garves' disease is slightly increased post-irradiation (Jereczek-Fossa et al, 2004).…”

Section: Radiation-induced Primary Thyroid Dysfunctionmentioning

confidence: 75%

Endocrine Complications Following Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma

Darzy¹

2012

Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma

View full text Add to dashboard Cite

“…Thyroid damage is initially manifested within 6 months [17]. The peak incidence of primary hypothyroidism occurs 2-3 years after treatment, with approximately 50% of these events occurring within the first 5 years of radiotherapy [13,15,18]. A higher dose portends a shorter latency period [18], and there appears to be no time when the incidence levels off.…”

Section: Discussionmentioning

confidence: 99%

“…External-beam radiotherapy has been known to induce various thyroid disorders, such as primary hypothyroidism (3%-92%), Graves' disease (0.1%-2%), silent thyroiditis (0.6%-3%), Hashimoto's thyroiditis (0.7%-48%), Graves' ophthalmopathy (0.2%-1.3%), benign adenoma (0.6%-3%), and thyroid cancer (0.35%) [13][14][15][16]. External-beam radiation is known to promote the release of excessive thyroid hormones during treatment, thereby suppressing TSH via negative feedback ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Storm After Intensity-Modulated Radiation Therapy: A Case Report and Discussion

et al. 2009

View full text Add to dashboard Cite

A 43-year-old man with locally advanced squamous cell carcinoma of the base of tongue was treated with induction chemotherapy followed by intensity-modulated radiation therapy (IMRT). Within 20 days posttreatment, the patient developed clinical symptoms highly suggestive of hyperthyroidism. Two and one half months after completion of therapy, the patient developed severe thyrotoxicosis, which, in retrospect, appears to have met the criteria for thyroid storm. This case history illustrates a previously unreported, lifethreatening complication of external-beam radiation that should be considered in patients receiving IMRT therapy involving the thyroid. Diagnosis of the patient's hyperthyroidism and probable thyroid storm was difficult to recognize because of the significant overlap between the signs and symptoms of severe thyrotoxicosis and the expected toxicities of his cancer therapy. The Oncologist 2009;14:233-239 CASE STUDYA 43-year-old nonsmoker with unremarkable past medical and family histories presented with an enlarging mass in his left neck. For one month he had noted fatigue and left otalgia, and had expectorated bright red blood when waking up. He had no weight loss, fevers, chills, dysphagia, or night sweats. Examination demonstrated a bilateral base of tongue mass extending onto the left tonsil; a biopsy revealed poorly differentiated squamous cell carcinoma. A positron emission tomography/computed tomography (CT) scan confirmed a left base of tongue and tonsil tumor, crossing midline toward the right measuring 2.4 ϫ 4.2 ϫ 3.6 cm, extending to the base of the epiglottis and pre-epiglottic space, and causing deviation of the airway toward the right.

show abstract

Radiotherapy-induced thyroid disorders

Cited by 237 publications

References 133 publications

Thyroid function, autoimmunity and nodules in hematological malignancies

Thyroid function, autoimmunity and nodules in hematological malignancies

Endocrine Complications Following Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma

Thyroid Storm After Intensity-Modulated Radiation Therapy: A Case Report and Discussion

Contact Info

Product

Resources

About