Radiotherapy in the management of localized mucocutaneous oral lymphoma in dogs: 14 cases

Berlato, Davide; Schrempp, Diane; Steen, Nils Van den; Murphy, Sue

doi:10.1111/j.1476-5829.2011.00270.x

Cited by 25 publications

(28 citation statements)

References 11 publications

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“…The gross and microscopic of representative sections of the neoplasm revealed a growth similar to other bovine lymphomas [2,6,13]. In the canine species, the prevalence of oral cavity lymphomas is greater, and includes the epitheliotropic type as the more common presentation [1,20]. However, in the tumor affecting the cow of this report, no neoplastic cells were visualized in the mucosal epithelial lining of the oral cavity justifying the classification of the tumor as non-epitheliotropic lymphoma.…”

Section: Discussionsupporting

confidence: 53%

Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

Guizelini

Pupin

Barros

et al. 2019

Acta Scientiae. Vet.

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Background: Squamous cell carcinomas and lymphomas are the most prevalent neoplasms in cattle, the latter usually being attributed to infection by bovine leukemia virus (BLV). Neoplasms of the oral cavity are sporadic in cattle, with but a single case of lymphoma involving this anatomic site in a bovine reported to date. This paper reports a case of lymphoma involving the oral cavity of a dairy cow. The clinical and pathological aspects of the tumor are described and discussed.Case: A 39-month-old Holstein-Friesian cow was presented with weight loss and a tumorous growth in the left masseter region, tearing in the left eye, and mild ipsilateral exophthalmos. Treatment with antibiotics was unsuccessful. The tumor growth was 16 x 11 cm, with a soft center and firm periphery, multilobulated, with white intercalated with black and friable areas from which a fetid odor emanated. The cut surface was predominantly white-yellow. A cross-section of the head, caudal to the second molar, revealed a mass infiltrating and almost completely obliterating the left nasal cavity, destroying the frontal sinus, the ventral conchae, and the middle and ventral meatus, and compressing the common meatus. The tracheobronchial, mediastinal, and internal iliac lymph nodes were enlarged and masses with similar characteristics to those in the oral cavity replace their parenchyma. Microscopically, the mass consisted of large neoplastic lymphocytes arranged in a non-encapsulated and infiltrative mantle and supported by scarce fibrovascular tissue. The cytoplasm of neoplastic cells was scarce and had distinct boundaries; the nuclei were round or oval, the chromatin was finely granulated, and the prominent nucleolus had occasionally multiplied. Nuclear pleomorphism was marked and there were, on average, five mitotic figures per microscopic field of 400x. Similar neoplastic cells obliterated the normal structure of the tracheobronchial, mediastinal, and internal iliac lymph nodes. In the immunohistochemical examination, labeling was diffuse and moderate in the cytoplasm of neoplastic cells when a CD3 antibody was used, and negative when antibodies to CD79α, cytokeratin, and vimentin were used. Due to its characteristic markings in the immunohistochemistry panel, the neoplasm was classified as an unspecified peripheral T-cell lymphoma.Discussion: The diagnosis of lymphoma was based on clinical signs and gross and histopathological findings, and was confirmed by immunohistochemistry. Lymphomas in cattle are common in several organs as part of enzootic bovine leukosis, a virus-induced type of B-cell lymphoma. However, lymphomas are rare in the oral cavity. The clinical presentation observed in this case points to the upper alimentary tract as the primary site of the neoplasm once clinical respiratory signs were not observed in the cow. The neoplasm cells described here presented a T-cell profile in immunohistochemistry panel, suggesting that the tumor should be included in the sporadic form of bovine leukosis since B-cells are the cellular population in cases of enzootic bovine leukosis. However, since the diagnosis of enzootic leukosis was not definitively excluded in this case, the cause of the neoplasia cannot be conclusively determined. It is concluded that, although rare, lymphomas may indeed occur in the bovine oral cavity and should be included in the differentials list for tumoral growth in the lateral region of the bovine face.

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Section: Discussionsupporting

confidence: 53%

Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

Guizelini

Pupin

Barros

et al. 2019

Acta Scientiae. Vet.

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“…Radiotherapy can be used for local treatment or palliation for canine EL . In a retrospective case series of 14 dogs with mucocutaneous oral lymphomas (of which 12 had EL) treated with coarse fractionation radiotherapy, the ORR was 67% with a MST of 770 days .…”

Section: Discussionmentioning

confidence: 99%

“…The aetiology for this malignancy in dogs is unknown . The tumour tends to occur in the epidermis, superficial dermis and periadnexally, although oral mucosal and mucocutaneous forms have been described . Canine EL is typically a tumour of T lymphocytes, with the CD3 + and CD4‐/CD8+ phenotype most commonly expressed .…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome and prognosis of dogs with histopathological features consistent with epitheliotropic lymphoma: a retrospective study of 148 cases (2003–2015)

Chan¹,

Frimberger²,

Moore³

2017

Veterinary Dermatology

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Canine epitheliotropic lymphoma may be divided into cutaneous and mucocutaneous/mucosal forms. Solitary lesions have a better prognosis. Dogs with multiple lesions appear to benefit from chemotherapy and retinoid treatment, with those attaining complete remission having longer survival times. Multi-agent chemotherapy could be considered in dogs with cutaneous lesions that fail to respond to single-agent chemotherapy.

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“…Of these 14 dogs, 6 had T-cell epitheliotropic lymphoma. 10 Recent human studies have also shown promising results. 4,5 Masitinib is a tyrosine kinase inhibitor (TKI) targeting KIT receptor and platelet-derived growth factor receptor (PDGFR).…”

Section: Introductionmentioning

confidence: 99%

“…A case series with 14 dogs with mucocutaneous oral lymphomas treated with radiotherapy showed an overall response rate of 67%. Of these 14 dogs, 6 had T‐cell epitheliotropic lymphoma . Recent human studies have also shown promising results …”

Section: Introductionmentioning

confidence: 99%

Masitinib monotherapy in canine epitheliotropic lymphoma

Holtermann

Kiupel

Kessler

et al. 2015

Vet Comparative Oncology

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This study evaluated efficacy and side effects of masitinib in canine epitheliotropic lymphoma. Complete remission occurred in 2 of 10 dogs and lasted for median 85 days. Five dogs went into partial remission for median 60.5 days. Three pretreated dogs did not respond to therapy. Side effects occurred in six dogs and were mostly mild to moderate. Immunohistochemistry was available for eight dogs. KIT receptor was negative in all of them, six of eight lymphomas stained strongly positive for stem cell factor (SCF). platelet-derived growth factor (PDGF)-AA was weakly positive in two and negative in six. PDGF-BB was negative in four tumours, weakly positive in one and strongly positive in three. One was strongly positive for PDGF receptor (PDGFR)-, seven were negative for that receptor. Five showed strong expression of PDGFR-, two showed weak expression, one was negative. In conclusion, masitinib is effective in treating canine epitheliotropic lymphoma. But its effects are most likely not generated through the KIT receptor.

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Radiotherapy in the management of localized mucocutaneous oral lymphoma in dogs: 14 cases

Cited by 25 publications

References 11 publications

Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

Clinical outcome and prognosis of dogs with histopathological features consistent with epitheliotropic lymphoma: a retrospective study of 148 cases (2003–2015)

Masitinib monotherapy in canine epitheliotropic lymphoma

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