Radiotherapy for T1 Carcinoma of the Glottis

Tombolini, Vincenzo; Zurlo, Alfredo; Cavaceppi, P; Sarro, Agatina; Guidi, Carlo; Osti, Mattia Falchetto; Vitturini, A.; Banelli, E

doi:10.1177/030089169508100605

Cited by 12 publications

(11 citation statements)

References 40 publications

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“…The 8 Table 4 Disease-free survival rates during the first 5 years after initial therapy and successful treatment of recurrences disease-and recurrence-free survival after radiotherapy only was 80% [1], 84% [4], 94.2% [33], 92% T 1α and 80% T 1β [3], and 91.8% 3-year survival in 41 glottic tumors [21]. In 246 T 1 -T 2 patients, the 5-year survival was 83% after radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

How often is total laryngectomy necessary for the treatment of T1 failures after radiotherapy or cordectomy?

Markou

Nikolaou

Nalbadian

et al. 2002

European Archives of Oto-Rhino-Laryngology

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Between 1992 and 1998, 547 patients (pts) with laryngeal SCC were diagnosed and treated in our department, 145 (27%) of whom presented with glottic tumors T1N0M0 (125 T1a and 20 T1b). Seventy-eight (54%) were treated surgically with cordectomy and 67 (46%) with radiotherapy. After a median follow-up time of 43 months, 22 (15.2%) of the 145 pts presented with recurrent disease. In more detail, 16 (13%) of the 125 T1a pts and 6 (30%) of the 20 T1b pts had recurrences. Among the 78 surgically treated patients only 4 (5%) had recurrence, while 18 (27%) of the radiotherapy group relapsed. The difference is statistically significant (log rank test, P = 0.0001 < 0.05). After salvage treatment, of the 67 pts of the radiotherapy group 57 (85%) remain disease-free, 49 (73%) retaining their larynx intact and 1 only having undergone cordectomy. Among the cordectomy group 75 (96%) pts remain disease-free with only 1 having had a total laryngectomy. Using the Kaplan-Meier method and calculating the disease-free survival regardless of salvage treatment, there is no doubt that surgical treatment statistically is more successful than radiotherapy (log rank test, P = 0.01 < 0.05). Analysis of parameters such as tumor differentiation and T1a or T1b staging, which indeed influence the overall recurrence rate, did not alter the favorable outcome after surgical treatment.

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Section: Discussionmentioning

confidence: 99%

How often is total laryngectomy necessary for the treatment of T1 failures after radiotherapy or cordectomy?

Markou

Nikolaou

Nalbadian

et al. 2002

European Archives of Oto-Rhino-Laryngology

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“…The goal of treatment is to accomplish the best local control with the least toxicity. Voice preservation is usually admitted to be better following radiotherapy (RT) alone compared with any surgical modalities, based on retrospective data [2,3].…”

Section: Introductionmentioning

confidence: 99%

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Ekici¹,

Temelli²,

Eraslan³

et al. 2016

Med-Science

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Our aim was to determine the treatment outcomes and the prognostic factors affecting local control in early stage glottic carcinoma (ESGC) treated with definitive radiotherapy (RT). Between April 2003 and May 2015, 76 patients with ESGC were treated at Inonu University Hospital. There were 58 patients with T1a, 7 T1b and 11 with T2 tumors. Twenty-two patients were treated with conformal radiotherapy, 31 patients were treated with conventional RT and 23 patients were treated with intensity modulated radiotherapy as initial treatment. During a median follow-up of 51 months (range 6-136), 11 patients had failures. Five year overall survival rates were 73.7% in T1 and 81.8% T2. Local control rate was 85.5% in our patients. Patients who were over 61 years had significantly lower local control (p = 0.042). One patient treatment was interrupted because of grade 3 edema. One patient had grade 3 dermatitis, 2 patients grade 3 mucositis and 4 patients grade 3 edema, respectively. Our results suggest that curative radiotherapy is an effective treatment modality in ESGC without increasing toxicity. Age proved to be the only independent prognostic factor affecting local control after primary radiotherapy according to the results of this study.

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“…The goal of treatment is to achieve the best local control with the least toxicity. Voice preservation is generally accepted to be better following RT alone compared with any surgical procedure, based on retrospective data [21,43,65].…”

Section: Introductionmentioning

confidence: 99%

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

et al. 2004

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Radiotherapy for T1 Carcinoma of the Glottis

Abstract: Our series confirms that radiation therapy has a major role in the management of early glottic cancer, with results comparable to surgical approaches and with better voice preservation.

Cited by 12 publications

References 40 publications

How often is total laryngectomy necessary for the treatment of T1 failures after radiotherapy or cordectomy?

How often is total laryngectomy necessary for the treatment of T1 failures after radiotherapy or cordectomy?

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

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