Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

Zouhair, Abderrahim; Azria, D.; Coucke, Philippe; Matzinger, Oscar; Bron, Luc; Moeckli, Raphaël; Do, Huu-Phuoc; Mirimanoff, René-Olivier; Ozşahin, Mahmut

doi:10.1007/s00066-004-1164-y

Cited by 52 publications

(41 citation statements)

References 68 publications

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“…Numerous reports regarding the treatment of early stage glottic cancer have evaluated some prognostic factors, i.e., tumor volume, stage, tumor kinetics including p53 status, histological differentiation, intrinsic radiosensitivity, continued smoking during and after RT and hypoxia, low hemoglobin levels, poorly differentiated tumors, dose per fraction, total dose, overall treatment time, field size, beam energy, radiation technique, and anterior commissure involvement [3,[16][17][18][19][20][21][22][23][24][25]. These factors were not constantly presented to have a prognostic influence by all authors.…”

Section: Discussionmentioning

confidence: 99%

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Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Ekici¹,

Temelli²,

Eraslan³

et al. 2016

Med-Science

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Our aim was to determine the treatment outcomes and the prognostic factors affecting local control in early stage glottic carcinoma (ESGC) treated with definitive radiotherapy (RT). Between April 2003 and May 2015, 76 patients with ESGC were treated at Inonu University Hospital. There were 58 patients with T1a, 7 T1b and 11 with T2 tumors. Twenty-two patients were treated with conformal radiotherapy, 31 patients were treated with conventional RT and 23 patients were treated with intensity modulated radiotherapy as initial treatment. During a median follow-up of 51 months (range 6-136), 11 patients had failures. Five year overall survival rates were 73.7% in T1 and 81.8% T2. Local control rate was 85.5% in our patients. Patients who were over 61 years had significantly lower local control (p = 0.042). One patient treatment was interrupted because of grade 3 edema. One patient had grade 3 dermatitis, 2 patients grade 3 mucositis and 4 patients grade 3 edema, respectively. Our results suggest that curative radiotherapy is an effective treatment modality in ESGC without increasing toxicity. Age proved to be the only independent prognostic factor affecting local control after primary radiotherapy according to the results of this study.

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Section: Discussionmentioning

confidence: 99%

“…The goal of treatment is to accomplish the best local control with the least toxicity. Voice preservation is usually admitted to be better following radiotherapy (RT) alone compared with any surgical modalities, based on retrospective data [2,3].…”

Section: Introductionmentioning

confidence: 99%

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Ekici¹,

Temelli²,

Eraslan³

et al. 2016

Med-Science

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“…In glottic cancers the invasion of this region is considered a factor of poor prognosis for the chosen treatment [6][7][8][15][16][17][18][19][20][21][22][23][24][25][26][27]. this is due to the possibility of occurrence of neoplastic invasion of the thyroid cartilage [ Values are n (%) unless otherwise indicated.…”

Section: Discussionmentioning

confidence: 99%

“…In patients submitted to radiotherapy, a worse rate of local control can be noticed when there is invasion of the anterior commissure [6,7] and this can be considered a predictor of poor response to this treatment [8]. On the other hand, some studies show that there may not be any correlation between the invasion of the anterior commissure and the failure of radiation treatment [9,10].…”

Section: Introductionmentioning

confidence: 99%

Morphological Evaluation of Thyroid Cartilage Invasion in Early Glottic Tumors Involving the Anterior Commissure

Sava

Dedivitis

Gameiro

et al. 2018

ORL

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Introduction: The anterior commissure is an area of glottic cancer infiltration, even in early stages. Objective: To evaluate the invasion by tumors into the anterior commissure cartilage in surgical specimens of frontolateral laryngectomy. Methods: Forty-eight patients who had undergone frontolateral laryngectomy for T1b/T2 squamous cell carcinoma were included. Epidemiological and clinical aspects as well as morphological histopathological analysis were evaluated. Results: Of the 48 patients, 42 (87.5%) had T1b lesions and 6 (12.5%) had T2. Thirty-four cases (70.8%) showed healthy tissue between the tumor and the thyroid cartilage, 10 cases (20.8%) had a tumor in close proximity to the cartilage, and in 4 cases (8.3%) there was cartilage invasion. There was no major risk of adverse outcome in the groups with infiltration or tumor adjacent to the cartilage. Level of differentiation, mitotic index, nuclear irregularity, and the presence of nucleolus and tumor necrosis were not related to cartilage invasion. Conclusion: The infiltration of thyroid cartilage occurred in 8.3% of tumors and did not change the outcome in patients submitted to frontolateral laryngectomy. The morphological characteristics did not present any statistical significance.

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“…Radical radiotherapy and endoscopic laser surgery are established treatment modalities for early glottic cancer. Radiotherapy provides successful treatment results with local control rates between 80 and 92%, and a mean 5-year success rate of 85% in large studies [3,4,9,26,29,33,38,43,49,50,52,53,55]. On the other hand, surgical resection has been slightly higher, ranging between 88 and 94% and a mean rate of 90% in other larges studies [1,6,7,10,19,21,22,25,32,42,45].…”

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confidence: 99%

Multidisciplinary Approach in the Treatment of T1 Glottic Cancer

et al. 2010

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Decreased Local Control Following Radiation Therapy Alone in Early-Stage Glottic Carcinoma with Anterior Commissure Extension*

Abstract: For early-stage laryngeal cancer, outcome after RT is excellent. In case of anterior commissure extension, surgery or higher RT doses are warranted. Because of a high relapse risk, arytenoid protection should not be attempted.

Cited by 52 publications

References 68 publications

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Outcomes of radiotherapy in early stage glottic laryngeal carcinoma: a single center experience

Morphological Evaluation of Thyroid Cartilage Invasion in Early Glottic Tumors Involving the Anterior Commissure

Multidisciplinary Approach in the Treatment of T1 Glottic Cancer

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