Multidisciplinary Approach in the Treatment of T1 Glottic Cancer

Dinapoli, N.; Parrilla, Claudio; Galli, Jacopo; Autorino, Riccardo; Miccichè, Francesco; Bussu, Francesco; Boccadoro, Mario; D’Alatri, Lucia; Marchese, Maria Raffaella; Rigante, Mario; Lella, G. Di; Liberati, Luca; Almadori, Giovanni; Paludetti, Gaetano; Valentini, Vincenzo

doi:10.1007/s00066-010-2142-1

Cited by 42 publications

(9 citation statements)

References 52 publications

(59 reference statements)

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Section: Resultsmentioning

confidence: 99%

“…29–36 Sources of possible patient selection bias included the lack of exclusion of patients with recurrence disease and/or the need for second treatment with either surgery or XRT in 3 studies. 29,31,34 Consecutive enrollment was carried out in 3 of the 8 papers, and 1 additional paper discussed prospective collection of voice outcome data. No studies incorporated randomization; most stated that treatment decisions were made by patient preference, 29,34–36 and 3 did not specify treatment selection methods.…”

Section: Resultsmentioning

confidence: 99%

“…29,31,34 Consecutive enrollment was carried out in 3 of the 8 papers, and 1 additional paper discussed prospective collection of voice outcome data. No studies incorporated randomization; most stated that treatment decisions were made by patient preference, 29,34–36 and 3 did not specify treatment selection methods. 30–32 The study by Sjogren et al 33 included patients staged T1a, and all patients were considered eligible for both treatment options with a historical treatment selection method; all patients after 1999 received TLM, and all patients prior to 1996 received XRT.…”

Section: Resultsmentioning

confidence: 99%

“…VHI results from the studies are listed in Figure 3. Two of the included studies 29,31 showed a significant result favoring XRT over surgical intervention. The remaining 6 papers showed nonsignificant differences between treatment modalities.…”

Section: Resultsmentioning

confidence: 99%

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Voice Outcomes Following Radiation Versus Laser Microsurgery for T1 Glottic Carcinoma

Greulich

Parker

Lee

et al. 2015

Otolaryngol.--head neck surg.

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Objective Systematic review of literature on patient-reported voice handicap following T1 glottic squamous cell carcinoma treatment using transoral laser microsurgery or radiation therapy. Data Sources PubMed, Web of Science, and Scopus (1997–2013). Review Methods These data sources were searched for papers reporting Voice Handicap Index (VHI) after treatment of early glottic carcinoma. Review and reference crosschecking were performed using a priori selection criteria. Study data were abstracted and publication quality categorized independently by 2 authors. Corresponding authors were contacted to maximize data for analysis. Meta-analysis was performed only with studies that included both treatment modalities, to reduce heterogeneity and maximize rigor; random effects modeling was used to pool results. Results Eighteen publications were identified that reported VHI data following surgery and radiotherapy for T1 glottic carcinoma. No studies were randomized. When studies that reported multiple T-stages or systematic treatment selection bias were excluded, 8 retrospective cohort studies describing 362 patients were suitable for meta-analysis. Follow-up time (mean, 47 months; range, 1–298 mo) and extent of surgical excision varied across studies. Six studies showed no VHI difference between treatment arms; 2 favored radiotherapy over surgery (1 of which reported transmuscular cordectomy for all surgical patients); and none favored surgery. Meta-analysis showed no significant difference in post-treatment VHI between radiotherapy and surgery (mean difference, −5.52; 95% confidence interval, −11.40, 0.36; heterogeneity I2 = 61%, P = .01). Conclusion VHI scores were comparable following transoral laser microsurgery and radiation therapy for T1 glottic carcinoma in the current literature, suggesting no clinically significant difference in functional voice outcomes between treatment types.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Voice Outcomes Following Radiation Versus Laser Microsurgery for T1 Glottic Carcinoma

Greulich

Parker

Lee

et al. 2015

Otolaryngol.--head neck surg.

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“…In our study only 2 patients with T2N0 disease had laser the pooled mean disease-free survival rate was 84.8% [26]. Dinapoli N et al [27] reported on 143 patients with T1 glottic SCC; 73 underwent surgery and 70 underwent radiotherapy. The authors showed non-statistical significance of OS and disease-free survival DFS between the two treatment groups with better voice quality for patients treated with RT.…”

Section: Discussionmentioning

confidence: 54%

Clinical Outcome of Definitive Radiotherapy and/or Surgery in T1-2N0M0 Glottic Squamous Cell Carcinoma: A Single Institution Retrospective Report

Ibrahim¹,

Askoura²,

Aleem³

2018

JCT

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Background: The current treatment options of early glottic carcinoma are radiotherapy; trans laser microsurgery, and open surgery. However, the best treatment is still controversial due to lack of randomized controlled trials. We aimed to evaluate the treatment results and the prognostic factors of local control of early glottic squamous cell carcinoma patients (GSCC) T1-2N0M0 treated at our institution. Material and Methods: We retrospectively studied the charts of 52 patients with early GSCC T1-T2N0M0 from 2010-2015 at the Clinical Oncology Department, Ain-Shams University. 24 patients had T1 and 28 had T2 early glottic carcinoma. The overall survival OS, local control rate, and laryngeal preservation rate were evaluated. Kaplan-Meier method, Cox proportional hazards model were used to analyze the data. Results: Median duration of follow-up was 13 months. Thirty-eight patients received radiation treatment alone (73.1%), 7.7% of the patients underwent surgery alone, and 19.2% of the patients had surgery combined with radiotherapy. Local recurrence after radiation failure developed in 6/52 patients, all had T2 disease and were salvaged by total laryngectomy. The ultimate local control rate was 88.5%, and the ultimate laryngeal preservation rate was 77.2% (40/52 patients). The median OS of the 52 patients was 13 months (range 2-46 months). Univariate analysis of factors associated with poor local control showed that age > 60 years was the only significant factor (P = 0.048). Conclusion: Radiotherapy achieves high local control and laryngeal preservation rates for patients with early glottic carcinoma, and is associated with a low rate of severe complications compared to surgery. Salvage surgery is feasible after radiotherapy failure.

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Role of radiation oncology in modern multidisciplinary cancer treatment

et al. 2020

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Cancer care is moving from a disease-focused management toward a patient-centered tailored approach. Multidisciplinary management that aims to define individual, optimal treatment strategies through shared decision making between healthcare professionals and patient is a fundamental aspect of high-quality cancer care and often includes radiation oncology. Advances in technology and radiobiological research allow to deliver ever more tailored radiation treatments in an ever easier and faster way, thus improving the efficacy, safety, and accessibility of radiation therapy. While these changes are improving quality of cancer care, they are also enormously increasing complexity of decision making, thus challenging the ability to deliver quality affordable cancer care. In this review, we provide an updated outline of the role of radiation oncology in the modern multidisciplinary treatment of cancer. Particularly, we focus on the way some developments in key areas of cancer management are challenging multidisciplinary cancer care in the different clinical settings of early, locally advanced, and metastatic disease, thus highlighting some priority areas of research.

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Multidisciplinary Approach in the Treatment of T1 Glottic Cancer

Cited by 42 publications

References 52 publications

Voice Outcomes Following Radiation Versus Laser Microsurgery for T1 Glottic Carcinoma

Voice Outcomes Following Radiation Versus Laser Microsurgery for T1 Glottic Carcinoma

Clinical Outcome of Definitive Radiotherapy and/or Surgery in T1-2N0M0 Glottic Squamous Cell Carcinoma: A Single Institution Retrospective Report

Role of radiation oncology in modern multidisciplinary cancer treatment

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