Radiotherapy for Angiosarcoma: The 35-Year University of Florida Experience

Scott, Michael; Portnow, Leah H.; Marcus, Robert B.; Mendenhall, Nancy P.; Mendenhall, William M.; Indelicato, Daniel J.

doi:10.1016/j.ijrobp.2010.07.1428

Cited by 14 publications

(17 citation statements)

References 22 publications

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“…Other series have shown that tumors smaller than 5 cm or limited disease extent correlates with improved prognosis. 2,5,7,9,13,16 The insidious nature of cutaneous angiosarcoma of the head and neck often makes it difficult to ascertain actual tumor size and/or disease extent, which may be one of the reasons our series did not show prognostic significance for size. Whenever feasible, mapping biopsies are attempted to better appreciate tumor extent.…”

Section: Discussionmentioning

confidence: 83%

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Angiosarcoma of the Scalp and Face

Patel

Hayden

Hinni

et al. 2015

JAMA Otolaryngol Head Neck Surg

108

156

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Section: Discussionmentioning

confidence: 83%

“…Multiple institutional reports have corroborated the benefit of multimodality therapy, particularly the combination of surgery and radiation therapy. 5,7,[11][12][13] The use of adjuvant radiation therapy had a favorable impact on RFS and LRC. In addition, the association between the use of surgery and improvement in OS had a P value of .09.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Scalp and Face

Patel

Hayden

Hinni

et al. 2015

JAMA Otolaryngol Head Neck Surg

108

156

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“…Various researchers have reported that surgery improves the 5‐year survival rate compared with other treatments (odds ratio [OR] = 4.369; p = .002) and positive resection margins are associated with worse overall survival (Shin, Roh, Lee, & Yang, ; Trofymenko & Curiel‐Lewandrowski, ; Vogt et al, ). As ASs are associated with a high chance of recurrence even after complete resection of the tumor, several investigators have used adjuvant radiation therapy to achieve better local control of the disease (Kinard, Zwicker, Schmidt‐Ullrich, Kaufman, & Pieters, ; Scott et al, ). Currently, wide local excision followed by radiation is the most accepted treatment for AS (Monroe et al, ).…”

Section: Discussionmentioning

confidence: 99%

Increased risk of angiosarcoma secondary to cancer radiotherapy: Case series and review of the treatment options

Goldust

Giulini

Weidenthaler-Barth

et al. 2020

Dermatologic Therapy

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Angiosarcomas (ASs) are aggressive tumors of vascular endothelial origin, occurring sporadically or in association with prior radiotherapy or chronic lymphedema. With only 1–5% of all sarcomas, the incidence seems low, but for the affected patient due to the extremely poor prognosis and the limited treatment options, the fate is often inevitable. Radiotherapy, chemotherapy, or “target therapy” have been used in the management of AS, but represent individual case decisions without lasting evidence. Over the past few years, breast‐conserving surgery followed by radiation therapy, known as breast‐conserving therapy (BCT), is being employed as a standard treatment for early‐stage breast cancer, but there has been an increase in reports of AS following BCT. We report two cases of AS following BCT and one case of primary AS involving the lower limb.

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“…Preoperative radiation followed by resection is advised in borderline resectable cases. The dose recommendations include 45 to 50 Gy for undissected subclinical disease, 60 to 65 Gy for a postoperative tumor bed with positive microscopic margins, and 70 to 75 Gy for gross disease [27]. Adjuvant radiation with or without chemotherapy is indicated for patients with high-grade STS [stage II-III; American Joint Committee on Cancer, Cancer Staging Manual, Seventh Edition (2010)].…”

Section: Radiation Therapymentioning

confidence: 99%

Primary angiosarcoma of chest wall inside out: A rare presentation

Mushtaq¹,

Sakral²,

Dogra³

et al. 2017

Our Dermatol Online

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Angiosarcomas are aggressive, malignant tumors of vascular or lymphatic origin with high potential to local and distant spread. Cutaneous invasion of internal tumors is rarely encountered in clinical practice. We report on a patient with vascular skin lesions over anterior chest which turned out to be incursion from chest wall angiosarcoma. Alongside the case report, literature on therapeutic arsenal of angiosarcoma is reviewed. Angiosarcoma of chest wall invading into the skin has never been reported in dermatological literature. This case is intriguing as the patient had symptomless progression of the malignancy despite aggressive invasion to overlying skin and metastasis to lungs and pleura. This impresses upon the crucial role of dermatologists in suspecting cutaneous lesions which may appear skin deep but are otherwise a silent sign of grave internal disease so that search of underlying condition is sought as soon as possible to achieve better patient outcome. So the dictum is "earlier the diagnosis, better the prognosis".

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Radiotherapy for Angiosarcoma: The 35-Year University of Florida Experience

Cited by 14 publications

References 22 publications

Angiosarcoma of the Scalp and Face

Angiosarcoma of the Scalp and Face

Increased risk of angiosarcoma secondary to cancer radiotherapy: Case series and review of the treatment options

Primary angiosarcoma of chest wall inside out: A rare presentation

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