Radiothérapie des chloromes ou sarcomes granulocytiques : revue de la littérature

Regression of a Myeloid Sarcoma of the Nasal Cavity With Extension to the Cheek After Radiotherapy

“…Concerning treatment strategies, a universal agreement has not yet been established with regard to therapeutic alternatives because of the rarity of the disease and the diversity of body sites and age groups [ 6 , 8 ]. The exclusive local treatments of isolated MS do not seem sufficient, since in the absence of systemic treatment the disease evolves inexorably towards acute leukaemia in 88-100% of cases versus 42% when systemic treatment is delivered to the patient [ 9 ]. In addition, several studies, including those of Tsimberidou et al [ 10 ], Imrie et al [ 11 ], and Cunningham et al [ 12 ] have shown an improvement in the probability of overall survival or survival without progression when a multimodal treatment was offered to the patient (more than 50% of surviving patients for a median follow-up of 25 months per compared to a median survival time of 13 months for untreated patients).…”

Adaptive Radiotherapy for an Uncommon Chloroma

“…Given its low incidence, the therapeutic management of GS is still not consensual. The current management strategies are based on a combination of systemic and local therapies, with a crucial role for RT [2]. …”

“…RT results in excellent local disease control and palliation of symptoms without significant toxicity. The recommended RT dose against chloromas is also not consensual, with at least 20 Gy in 10 fractions being most common [2, 6, 7]. …”

“…In terms of management strategy, combined treatment based on systemic and local therapy, including surgery or mainly radiotherapy (RT), is indicated in the large majority of cases. In the treatment sequence, RT can play a central role because of the high radiosensitivity of the tumor using a minimal dose [2, 3]. While several chloroma tumor sites have been reported in the literature, to our knowledge, none have been treated with adaptive RT (ART) [2].…”

“…In the treatment sequence, RT can play a central role because of the high radiosensitivity of the tumor using a minimal dose [2, 3]. While several chloroma tumor sites have been reported in the literature, to our knowledge, none have been treated with adaptive RT (ART) [2]. The aim of the ART approach is to identify an early response and the need for replanning treatment for patients receiving RT against such a radiosensitive tumor.…”