Radiotherapy for isolated granulocytic sarcoma: Case report and review of literature

Rullán, J.A. Domínguez; Lizarbe, Eva Fernández; Capuz, B.; Piris, Miguel Á.; García, Sonsoles Sancho

doi:10.1016/j.ctro.2017.11.001

Cited by 3 publications

(7 citation statements)

References 15 publications

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“…Surgical resection or radiation may be considered for local symptom relief. Local radiation to the site of disease improves failure-free survival but has not been shown to improve overall survival [12] . Nonetheless, it is still commonly performed for local control and symptomatic relief.…”

Section: Discussionmentioning

confidence: 98%

Focal blast crisis in concomitant myelodysplastic syndrome and chronic myelogenous leukemia

Reap

Goldman

2020

Leukemia Research Reports

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Leukemic transformation of myelodysplastic syndrome (MDS) or chronic myelogenous leukemia (CML) is a well-established phenomenon. However, co-occurrence of MDS and CML is a rare phenomenon, with few reports to date. Though blast crisis typically occurs systemically with MDS or CML, rare reports of focal transformation with myeloid sarcoma (MS) have been described. We present the first known case of concomitant MDS and CML on imatinib that developed focal blastic transformation, where the leukemic clone was BCR-ABL1 positive. Local irradiation and second-generation TKI was enough to attain long-term remission. Herein, we discuss MS and its implications in both CML and MDS.

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Section: Discussionmentioning

confidence: 98%

Focal blast crisis in concomitant myelodysplastic syndrome and chronic myelogenous leukemia

Reap

Goldman

2020

Leukemia Research Reports

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“…Haematological malignancies may manifest as extramedullary soft tissue masses known as myeloid sarcomas, granulocytic sarcomas, extramedullary sarcomas or chloromas and are a rare extramedullary tumour of immature myeloid cells [3]. These may occur in isolation, or more commonly in patients with a history of Acute Myeloid Leukemia (AML), MDS, or in blast phase of Chronic Myeloid Leukemia (CML) [4].…”

Section: Discussionmentioning

confidence: 99%

“…Treatment strategies include systemic therapy while Radiotherapy (RT) and surgery have been used to improve local control [4]. RT alone is effective for local control but unlikely to provide long term disease control or cure.…”

Section: Discussionmentioning

confidence: 99%

“…With local therapy alone, progression usually occurs within 10-12 months after the diagnosis, suggesting that isolated MS should be considered as a systemic disease and initial treatment should include chemotherapy with or without transplantation [4,9]. A retrospective study from 1986 showed that 25% of patients initially treated without systemic therapy did not progress to haematological diseases during follow-up ranging from 3.5-16 years [10].…”

Section: Discussionmentioning

confidence: 99%

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Radiotherapy for Myeloid Sarcoma of the Breast: A Case Report and Review of the Literature

2023

annhematoloncol

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While the role of systemic therapy in the treatment of myeloid sarcoma is well documented, the evidence for the use of radiation therapy is sparse. We present a case of isolated myeloid sarcoma to the breast. Following treatment for myelodysplastic syndrome. Myeloid Sarcomas (MS) are also known as chloromas and granulocytic sarcomas. They are extramedullary tumours of immature myeloid cells that develop in the setting of Acute Myeloid Leukaemia (AML), Chronic Myeloid Leukaemia (CML) and accelerated phase MyeloDysplastic Syndrome (MDS) [1]. Treatment options include systemic therapy, localised radiation treatment or surgery. Retrospective series have identified that radiotherapy provides safe and reliable local control and symptom palliation [2]. We conducted a review of literature to assess the rationale, role, and dose of radiotherapy for this rare leukemia manifestation in the breast.

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“…The majority of patients with MS were referred for radiotherapy when there was extramedullary progression, marrow relapse, or rapid symptom relief required (42). However, there are no specific studies on the efficacy of radiotherapy for myeloid sarcomas of the spine (42,43).…”

Section: Discussionmentioning

confidence: 99%

Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review

Shu

Guo

et al. 2022

Front. Oncol.

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Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence. Myeloid sarcoma, which rarely happens in acute promyelocytic leukemias, is more common in recurrent patients after the advent of all-trans retinoic acid (ATRA) and are rare in untreated acute promyelocytic leukemia. We described a case of, to our knowledge, de novo myeloid sarcoma of the spine confirmed as acute promyelocytic leukemia. Myeloid sarcoma is diagnosed by spinal tumor biopsy, and microscopic examination of a bone marrow smear and cytogenetic analysis led to a confirmed diagnosis of acute promyelocytic leukemia.

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Radiotherapy for isolated granulocytic sarcoma: Case report and review of literature

Abstract: HighlightsIsolated chloroma should be considered as a systemic disease.Consolidation radiotherapy has been related with prolonged failure free survival.Excellent local control of chloroma is achieved with low-dose radiotherapy.

Cited by 3 publications

References 15 publications

Focal blast crisis in concomitant myelodysplastic syndrome and chronic myelogenous leukemia

Focal blast crisis in concomitant myelodysplastic syndrome and chronic myelogenous leukemia

Radiotherapy for Myeloid Sarcoma of the Breast: A Case Report and Review of the Literature

Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review

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