Radiosynoviorthesis (RSO): influencing factors and therapy monitoring

Abstract

The success of RSO is higher in patients with RA than in patients with OA. For the finger, ankle, and wrist joints in RA, RSO is so promising that we would like to advocate its preference over the sole intraarticular corticoid injection. Perfusion bone scintigraphy can be used for therapy monitoring and earlier switching to RSO by showing that other therapies have failed.

Radiosynoviorthesis of acromioclavicular joint using 169Er-citrate: prospective evaluation of efficacy

“…In patients with rheumatoid arthritis and osteoarthritis, the clinical and scintigraphic outcomes were observed mainly in joints with decreasing blood pool indices and the response to RSO according to BPI was associated with subjective response in 129/157 (82.2 %) in the study of Zuderman et al [13], underlining the BS as a valuable tool for monitoring RSO efficacy [8,13]. In our study the two-phase BS including BPI and bone phase was performed less than 2 months prior and 4-8 months after RSO.…”

“…Increased articular blood pool perfusion in patients with rheumatologic conditions is indicative of active inflammation and has been suggested as a strong predictor of response to RSO [13]. In patients with rheumatoid arthritis and osteoarthritis, the clinical and scintigraphic outcomes were observed mainly in joints with decreasing blood pool indices and the response to RSO according to BPI was associated with subjective response in 129/157 (82.2 %) in the study of Zuderman et al [13], underlining the BS as a valuable tool for monitoring RSO efficacy [8,13].…”

Radionuclide Therapy of Inflammatory Joint Diseases (Radiation Synovectomy, Radiosynoviorthesis)

“…In 60-80 %, the results 1 year after RSO were classified as good or excellent. In nonrheumatoid diseases with chronic inflammatory synovium,-including OA-the efficacy of RSO showed response rates between 40 and 80 % (Gumpel et al 1979;Zuderman et al 2008). RSO is recommended as an effective treatment in OA and inflammatory joint disorders not caused by RA (Kröger et al 1999).…”

Radiosynoviorthesis in Therapy for Inflammatory Joint Disorders

“…L. Zuderman и соавт. [28] изучали поглощение в мягкотканную фазу после проведения РСО 424 суставов у 136 пациентов. Поглощение значительно снизилось в 81% мелких суставов кистей и стоп и в 69% средних суставов (плечевых, лучезапястных и голеностоп-ных).…”