Radiosurgery with the first Austrian cobalt-60 Gamma-unit

Purpose During the past two decades, radiosurgery has arisen as a promising approach to the management of glomus jugulare. In the present study, we report on a systematic review and meta-analysis of the available published data on the radiosurgical management of glomus jugulare tumors. Methods and Materials To identify eligible studies, systematic searches of all glomus jugulare tumors treated with radiosurgery were conducted in major scientific publication databases. The data search yielded 19 studies, which were included in the meta-analysis. The data from 335 glomus jugulare patients were extracted. The fixed effects pooled proportions were calculated from the data when Cochrane’s statistic was statistically insignificant and the inconsistency among studies was <25%. Bias was assessed using the Egger funnel plot test. Results Across all studies, 97% of patients achieved tumor control, and 95% of patients achieved clinical control. Eight studies reported a mean or median follow-up time of >36 months. In these studies, 95% of patients achieved clinical control and 96% achieved tumor control. The gamma knife, linear accelerator, and CyberKnife technologies all exhibited high rates of tumor and clinical control. Conclusions The present study reports the results of a meta-analysis for the radiosurgical management of glomus jugulare. Because of its high effectiveness, we suggest considering radiosurgery for the primary management of glomus jugulare tumors.

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“…Using this method, 47 studies were initially identified (Fig. 1) (3, 4, 7–51). From this pool, 20 reviews or off-topic studies were excluded.…”

Section: Methodsmentioning

confidence: 99%

Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis

Guss

Batra

Limb

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

105

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“…While conventionally fractionated radiation therapy has a longer history in GJT management, inclusion of SRS in the therapeutic armamentarium dates back to mid-1990s [27,28]. Thus, nearly 2 decades of experience with GJT radiosurgery is currently available.…”

Section: Practice Pointsmentioning

confidence: 99%

“…While SRS techniques are currently capable of utilizing different types of radiation including heavy charged particles and protons, photon irradiation is more commonly used partly due to widespread availability with easier access and lower cost. Major platforms for GJT radiosurgery include the Gamma knife, Cyber knife and other LINAC-based systems all of which have been shown to achieve favorable treatment outcomes [21][22][23][24]27,28,30,. The recognition of SRS as a viable treatment modality has prompted continual development of novel technologies providing higher speed, comfort and precision.…”

Section: Practice Pointsmentioning

confidence: 99%

Stereotactic radiosurgery of glomus jugulare tumors: current concepts, recent advances and future perspectives

2015

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Stereotactic radiosurgery (SRS), a very highly focused form of therapeutic irradiation, has been widely recognized as a viable treatment option in the management of intracranial pathologies including benign tumors, malign tumors, vascular malformations and functional disorders. The applications of SRS are continuously expanding thanks to the ever-increasing advances and corresponding improvements in neuroimaging, radiation treatment techniques, equipment, treatment planning and delivery systems. In the context of glomus jugulare tumors (GJT), SRS is being more increasingly used both as the upfront management modality or as a complementary or salvage treatment option. As its safety and efficacy is being evident with compiling data from studies with longer follow-up durations, SRS appears to take the lead in the management of most patients with GJT. Herein, we address current concepts, recent advances and future perspectives in SRS of GJT in light of the literature.

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“…[28] Many meningiomas treated with radiosurgery have shown a reduction in tumor volume. [11,18,19,28,37] Several short-term reports have stated, in general, that radiosurgical treatment of meningiomas is safe and well tolerated. [19,20,26,28] Most of these data come from Lunsford's group at University of Pittsburgh, which was the site of the first North American gamma knife unit.…”

Section: Radiosurgical Treatmentmentioning

confidence: 99%

Current status of radiation therapy and radiosurgery in the treatment of intracranial meningiomas

Engelhard

1997

FOC

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Complete surgical removal, including resection of involved bone and dura, is curative of intracranial meningiomas in approximately 90% of cases. However, complete removal may entail unwarranted risk if the tumor involves or is adjacent to critical vascular or neural structures. In addition, it is possible for fragments of tumor to “evade” resection, even with the use of meticulous microsurgical technique. Because of this, clinicians may be faced with the decision of whether to offer or recommend radiation therapy or radiosurgery to a patient with a residual or recurrent meningioma. For many years, it has been recommended that external-beam radiation therapy be considered in the treatment of incompletely resected or malignant meningiomas. More recently, the role of radiosurgery as adjuvant or even primary therapy for meningiomas has attracted considerable attention. This article presents a review of the literature on postoperative radiotherapy of intracranial meningiomas.

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Radiosurgery with the first Austrian cobalt-60 Gamma-unit

Cited by 8 publications

References 37 publications

Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis

Radiosurgery of Glomus Jugulare Tumors: A Meta-Analysis

Stereotactic radiosurgery of glomus jugulare tumors: current concepts, recent advances and future perspectives

Current status of radiation therapy and radiosurgery in the treatment of intracranial meningiomas

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