Radiosensitizers in Radiation-Induced Cancer Therapy

Rashidzadeh, Hamid; Mozafari, Faezeh; Rahimi, Hossein; Ghaffarlou, Mohammadreza; Ramazani, Ali; Abazari, Morteza; Rahmati, Mohammad-Amin; Danafar, Hossein; Anwar, Hafeez; Sharma, S. K.; Kavetskyy, Taras

doi:10.1007/978-3-031-04071-9_2

Cited by 4 publications

(1 citation statement)

References 162 publications

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“…Radiosensitizers are the agents introduced into the tumor in order to make the tumor cells more vulnerable during radiation therapy. They increase the absorption of energy and its deposition in cancer cells under ionizing radiation [1]. One of the new rapidly developing branches of radiation therapy is Auger therapy [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Cross sections of cascade production of photoions after photoionization of the iodine atom in the 0.01–100 keV incident photon energy range

Chaynikov,

Kochur,

Dudenko

2024

Phys. Scr.

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Ion yields upon the cascade decays of single vacancies in K to O shells of an isolated iodine atom are calculated by the method of construction and analysis of the cascade decay trees. Branching ratios needed for the simulations are calculated based on Pauli–Fock partial transition widths. Partial photoionization cross sections are calculated with accounting for the core relaxation effect and used to calculate the cross sections of I q+ photoions production in the 0.01–100 keV incident photon energy range. Accounting for the spin-orbit splitting and the splitting due to electron-electron interaction is shown to be important when calculating mean energies and probabilities of the transitions between energetically closely lying ionic configurations. On the other hand, inclusion of the additional shake-off electron ejections, in spite of complicating severely the decay trees, is found to affect little calculated cascade ions production probabilities.

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Section: Introductionmentioning

confidence: 99%

Cross sections of cascade production of photoions after photoionization of the iodine atom in the 0.01–100 keV incident photon energy range

Chaynikov,

Kochur,

Dudenko

2024

Phys. Scr.

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Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations

Xue,

Pilehvar,

Afshari

et al. 2024

Applied Organom Chemis

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Radiotherapy (RT), which is a therapeutic treatment modality that is commonly used for cancer, employs high‐energy irradiation to induce the generation of reactive oxygen species (ROS) and to cause DNA damages. Nevertheless, the therapeutic efficacy of RT is predominantly constrained due to inadequate DNA damage in malignancies and deleterious impacts on healthy tissues. In the current study, bovine serum albumin (BSA)–coated AgBiS2 nanodots, also known as AgBiS2@ BSA nanodots, were developed for enhanced breast cancer treatment. This was accomplished by the use of an extremely simple and eco‐friendly method. Both scanning transmission electron microscopy (STEM) and scanning electron microscopy (SEM) images revealed that prepared nanoradiosensitizers, AgBiS2@ BSA, were spherical in shape and uniformly distributed. AgBiS2@ BSA nanodots possessed excellent biocompatibility and exhibit excellent monodispersity as well. Furthermore, in vitro assays such as MTT, colony formation assay, and intracellular ROS generation assay revealed the significant cell inhibitory impact of the produced AgBiS2@ BSA nanodots under X‐ray irradiation under X‐ray irradiation. Remarkably, the combined administration of AgBiS2@ BSA nanodots along with X‐ray irradiation increased ROS level within cells by increasing the localized radiation dosage and improving the anti‐tumor effectiveness of RT.

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Cascade energy reemission by the iodine atom irradiated by 0.01–100 keV photons. Role of photo- and cascade-produced electrons in radiosensitization using iodine-containing agents

Chaynikov,

Kochur,

Dudenko

2024

Journal of Quantitative Spectroscopy and Radiative Transfer

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Radiosensitizers in Radiation-Induced Cancer Therapy

Cited by 4 publications

References 162 publications

Cross sections of cascade production of photoions after photoionization of the iodine atom in the 0.01–100 keV incident photon energy range

Cross sections of cascade production of photoions after photoionization of the iodine atom in the 0.01–100 keV incident photon energy range

Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations

Cascade energy reemission by the iodine atom irradiated by 0.01–100 keV photons. Role of photo- and cascade-produced electrons in radiosensitization using iodine-containing agents

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Radiosensitizers in Radiation-Induced Cancer Therapy

Cited by 4 publications

References 162 publications

Cross sections of cascade production of photoions after photoionization of the iodine atom in the 0.01–100 keV incident photon energy range

Cross sections of cascade production of photoions after photoionization of the iodine atom in the 0.01–100 keV incident photon energy range

Radiosensitization of breast cancer cells with AgBiS2 nanodots: Preparation and in vitro evaluations

Cascade energy reemission by the iodine atom irradiated by 0.01–100 keV photons. Role of photo- and cascade-produced electrons in radiosensitization using iodine-containing agents

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Radiosensitization of breast cancer cells with AgBiS₂ nanodots: Preparation and in vitro evaluations