Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

Rashid, Raizulnasuha Abdul; Abidin, Safri Zainal; Anuar, Muhammad Afiq Khairil; Tominaga, Takahiro; Akasaka, Hiroaki; Sasaki, Ryohei; Kie, Katahira; Razak, Khairunisak Abdul; Pham, Binh T.T.; Hawkett, Brian S.; Carmichael, Mary-Ann; Geso, Moshi; Rahman, Wan Nordiana

doi:10.1016/j.onano.2018.100027

Cited by 54 publications

(51 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…67 The assumption is also particularly correct in which the ROS induced in HCT-116 cells after irradiated by proton beam in the presence of BiONPs surpassed the ROS induced in the presence of platinum, gold, or superparamagnetic iron oxide NPs. 15 Although the physical interaction of the proton beam with cells is disparate from the clinical beams in the present study, the authors also implied that ROS production was firmly related to the radiosensitization effect and found that BiONPs could produce the highest SER among other NPs tested. 15 Other bismuth-based NPs such as folic acid (FA) modified bismuth sulfide NPs, folate-inserted RBC membranes-coated bismuth NPs, and 5-Aminolevulinic acid-FAconjugated BiONPs, which were tested against X-ray and photodynamic irradiations, also showed the enhancement of ROS levels relative to respective controls.…”

Section: Dovepressmentioning

confidence: 55%

“…15 Although the physical interaction of the proton beam with cells is disparate from the clinical beams in the present study, the authors also implied that ROS production was firmly related to the radiosensitization effect and found that BiONPs could produce the highest SER among other NPs tested. 15 Other bismuth-based NPs such as folic acid (FA) modified bismuth sulfide NPs, folate-inserted RBC membranes-coated bismuth NPs, and 5-Aminolevulinic acid-FAconjugated BiONPs, which were tested against X-ray and photodynamic irradiations, also showed the enhancement of ROS levels relative to respective controls. [68][69][70] Even though bismuth has a higher atomic number than platinum or gold, the oxide element that presents with the bismuth had caused molecular changes and decreased the atomic number of Bi 2 O 3 to a comparable platinum element (Z eff =78).…”

Section: Dovepressmentioning

confidence: 55%

“…International Journal of Nanomedicine 2020:15 7814 atomic number (Z) metallic NPs such as platinum (Z=78), gold (Z=79), and bismuth (Z=83). 9,15,66 Hossain and Su also simulated the radiosensitizing effects of several diagnostic X-ray energies among bismuth, gold as well as platinum, and stated that the irradiations which released photoelectrons and Auger electrons could cause water molecules to be lysed and formed various free radicals. 67 The assumption is also particularly correct in which the ROS induced in HCT-116 cells after irradiated by proton beam in the presence of BiONPs surpassed the ROS induced in the presence of platinum, gold, or superparamagnetic iron oxide NPs.…”

Section: Dovepressmentioning

confidence: 99%

“…[11][12][13][14] Apart from gold and bismuth oxide NPs, platinum and superparamagnetic iron oxide NPs (SPIONs) also had the potential to be a radiosensitizer, as our previous research on the four types of NPs under 150 MeV proton beam found to have sensitization enhancement ratio (SER) values of 1.95 to 4.93. 15 The dendrite-shaped platinum NPs with the sizes of 29 to 52 nm were also discovered to cause the radiosensitization effect with SER of 1.77 to 2.31 for photon beam radiotherapy, while a smaller size of platinum NPs (1.7 nm) demonstrated the amplification of the effect from cobalt-60 radiation by 37%. 16,17 Current translational applications of NPs observed that gadolinium, SPIONs and hafnium oxide NPs had accomplished the radiosensitization effects in Phase 1 of clinical trials.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Sisin¹,

Razak²,

Abidin³

et al. 2020

IJN

Self Cite

View full text Add to dashboard Cite

This study aimed to quantify synergetic effects induced by bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) and baicalein-rich fraction (BRF) natural-based agent on the reactive oxygen species (ROS) generation and radiosensitization effects under irradiation of clinical radiotherapy beams of photon, electron and HDR-brachytherapy. The combined therapeutic responses of each compound and clinical radiotherapy beam were evaluated on breast cancer and normal fibroblast cell line. Methods: In this study, individual BiONPs, Cis, and BRF, as well as combinations of BiONPs-Cis (BC), BiONPs-BRF (BB) and BiONPs-Cis-BRF (BCB) were treated to the cells before irradiation using HDR brachytherapy with 0.38 MeV iridium-192 source, 6 MV photon beam and 6 MeV electron beam. The individual or synergetic effects from the application of the treatment components during the radiotherapy were elucidated by quantifying the ROS generation and radiosensitization effects on MCF-7 and MDA-MB-231 breast cancer cell lines as well as NIH/3T3 normal cell line. Results: The ROS generated in the presence of Cis stimulated the most substantial amount of ROS compared to the BiONPs and BRF. Meanwhile, the combination of the components had induced the higher ROS levels for photon beam than the brachytherapy and electron beam. The highest ROS enhancement relative to the control is attributable to the presence of BC combination in MDA-MB-231 cells, in comparison to the BB and BCB combinations. The radiosensitization effects which were quantified using the sensitization enhancement ratio (SER) indicate the highest value by BC in MCF-7 cells, followed by BCB and BB treatment. The radiosensitization effects are found to be more prominent for brachytherapy in comparison to photon and electron beam. Conclusion: The BiONPs, Cis and BRF are the potential radiosensitizers that could improve the efficiency of radiotherapy to eradicate the cancer cells. The combination of these potent radiosensitizers might produce multiple effects when applied in radiotherapy. The BC combination is found to have the highest SER, followed by the BCB combination. This study is also the first to investigate the effect of BRF in combination with BiONPs (BB) and BC (BCB) treatments.

show abstract

Section: Dovepressmentioning

confidence: 55%

Section: Dovepressmentioning

confidence: 55%

Section: Dovepressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Sisin¹,

Razak²,

Abidin³

et al. 2020

IJN

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nanoparticles (NPs), particularly high Z number metal elements, have been extensively studied due to their high absorption of X-ray photons leading to large increases in secondary electrons and subsequent increase levels of DNA damage by physically enhancing the dose (8)(9)(10). However, high Z metal NPs have also been shown to act through distinct biological mechanisms including higher levels of oxidative stress, increasing levels of reactive oxygen species (ROS) and inducing highly reactive hydroxyl radicals which go on to cause further DNA damage (10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Impact of Superparamagnetic Iron Oxide Nanoparticles on In Vitro and In Vivo Radiosensitisation of Cancer Cells

Russell

Dunne

Russell

et al. 2020

Preprint

View full text Add to dashboard Cite

Purpose The recent implementation of MR-Linacs has highlighted theranostic opportunities of contrast agents in both imaging and radiotherapy. There is a lack of data exploring the potential of superparamagnetic iron oxide nanoparticles (SPIONs) as radiosensitisers. This study aimed to characterise the uptake and radiobiological effects of SPIONs in tumour cell models in vitro and to provide proof-of-principle application in a xenograft tumour model. Methods SPION uptake was measured using ICP-MS in 6 cancer cell lines; H460, MiaPaCa2, DU145, MCF7, U87 and HEPG2. The impact of SPIONs on radiobiological response was determined by measuring DNA damage using 53BP1 immunofluorescence and cell survival. Measured dose enhancement factors (DEFs) were with the predicted DEFs based on physical absorption estimations. In vivo efficacy was demonstrated using a subcutaneous H460 xenograft tumour model in SCID mice by following intra-tumoural injection of SPIONs. Results SPIONs significantly increased DNA damage in all cell lines with the exception of U87 cells at a dose of 1 Gy, 1 hr post-irradiation. Levels of DNA damage correlated with the cell survival, in which all cell lines except U87 cells showed an increased sensitivity (P < 0.05) in the linear quadratic curve fit for 1 hr exposure to 0.1 mM SPIONs. There was also a 30.1 % increase in the number of DNA damage foci found for HEPG2 cells at 2 Gy. No strong correlation was found between SPION uptake and DNA damage at any dose, yet the biological consequences of SPIONs on radiosensitisation were found to be much greater, with DEFs up to 1.28 ± 0.03, compared with predicted physical dose enhancement levels of 1.0001. In vivo , intra-tumoural injection of SPIONs combined with radiation showed significant tumour growth delay compared to animals treated with radiation or SPIONs alone (p < 0.05). Conclusions SPIONs showed radiosensitising effects in 5 out of 6 cancer cell lines. No correlation was found between the cell-specific uptake of SPIONs into the cells and DNA damage levels. The in vivo study found a significant decrease in the tumour growth rate.

show abstract

Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers

Denkova

Liu

Men

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

Next to surgery, radiotherapy and chemotherapy are the two most commonly applied treatments against cancer. These therapies are often combined, but the therapeutic outcome is still limited. Nanocarriers may be the solution to many of the issues encountered when combining these therapies. In this review, the role of nanocarriers in combined radiotherapy and chemical cancer treatment is discussed, divided into four distinct strategy classes. For each strategy, examples of the literature are given to come eventually to conclusion on the possible translation to the clinic.

show abstract

Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam

Cited by 54 publications

References 36 publications

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>

Impact of Superparamagnetic Iron Oxide Nanoparticles on In Vitro and In Vivo Radiosensitisation of Cancer Cells

Enhanced Cancer Therapy by Combining Radiation and Chemical Effects Mediated by Nanocarriers

Contact Info

Product

Resources

About