Radioprotective efficacy of<i>Ginkgo biloba</i>and<i>Angelica archangelica</i>extract against technetium-99m-sestamibi induced oxidative stress and lens injury in rats

Khedr, M.H.; Shafaa, Medhat W.; Abdel-Ghaffar, Amany; Saleh, Ahmed M.

doi:10.1080/09553002.2018.1407463

Cited by 14 publications

(16 citation statements)

References 40 publications

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“…The increase in chronic degenerative diseases has led to a growing interest in phytotherapeutic products since they are low-cost options and normally do not have important adverse effects. In that context, EGB761 presents an essential relevance for its antioxidant and anti-inflammatory properties [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…EGB761 has been used for the treatment of a series of comorbidities related to oxidative stress and, due to its antioxidant na-ture, it can decrease oxidative processes and neutralize lipid peroxidation. Among the bioactive components of EGB761, we can highlight flavonoids (about 28 %) such as quercetin, kaempferol isorhamnetin, lipoxygenase, phospholipase A2, and terpenic lactones (2.8-3.4 % of ginkgolídeos A, B, and C and 2.6-3.2 % bilobalide) (▶ Table 2) [9,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…The leaves and seeds of this plant have been used for medicinal purposes in China for centuries, initially being used for asthma and problems in the digestive system. In Europe and the USA, they have been sold since the sixties, and now they represent one of the most popular phytotherapeutic products in the world [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

et al. 2020

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ABSTR AC TGinkgo biloba (GB) is one of the most widely used phytotherapeutic products in the world, and its extract has beneficial properties for the treatment of several pathologies, such as diabetic cardiomyopathy, neurodegenerative diseases, cataracts, hearing loss, myocardial lesion, hippocampus neuronal lesions, morphometry testicular changes, and liver damage. This review aims to investigate the effects of GB on diseases related to oxidative stress. Databases such as MEDLINE/ PUBMED and EMBASE were consulted, and PRISMA guidelines were used to build the review. This plant has antioxidant properties since it regulates the expression of antioxidant enzymes positively and reduces reactive oxygen and nitrogen species, contributing to the reduction of lipid peroxidation. It also exhibits anti-inflammatory properties, inhibiting the expression of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-α. In animal models, the use of GB can show positive effects on brain damage, neurodegenerative diseases, myocardial injury, and renal and liver damage. In humans, the positive effects were shown in diabetes, metabolic syndrome, and ischemic colitis. These effects are due to the presence of compounds such as bilobalide, isoramnetina, quercetin, kaempferol, and ginkgolides A, B, and C. For these reasons, GB can be a lowcost alternative to the therapeutic approach of several pathologies since it acts in the prevention, treatment, and inhibition of several complications of common comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

et al. 2020

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“…This very sensitive condition is the main principle that reflects alterations in hemoglobin function when subjected to any ionization [22]. Oxidative stress due to the excessive formation of reactive oxygen species (ROS) is one of the most common processes when blood is exposed to radioactive isotopes [5,23]. In elevated oxidative stress situations, the essential redox system may need external supplementation to restore the direct and indirect imbalance of ROS.…”

Section: Discussionmentioning

confidence: 99%

A Combined Protective Dose of Angelica archangelica and Ginkgo biloba Restores Normal Functional Hemoglobin Derivative Levels in Rabbits after Oxidative Stress Induced by Gallium-68

et al. 2021

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Oxidative stress is a physiological imbalance between the production of reactive oxygen species (ROS) and the body’s ability to detoxify these products. Oxidative stress induced by ionizing radiation is one of the late biological effects of radiation. The aim of this study was to assess the protective role of Angelica archangelica and Ginkgo biloba extracts, which are commonly used as antioxidants in counteracting effects related to functional and non-functional hemoglobin derivative concentrations, as well as the rate of hemoglobin autoxidation before exposing rabbits to ionizing radiation. The experimental design included four groups of rabbits: a control group that did not receive gallium or antioxidants; Group 1, which received 68Ga isotope as a source of ionizing radiation with no prior treatment; Groups 2 and 3, which received A. archangelica and G. biloba root powder water extracts, respectively, for seven days prior to irradiation; and Group 4, which received a combined dose of both antioxidants, A. archangelica and G. biloba, prior to irradiation, with the same dose, time, and duration as used in Groups 2 and 3. The results demonstrate that both antioxidants had the ability to counteract oxidative stress induced by ionizing radiation, as well as to reduce the hemoglobin autoxidation rate. A synergistic effect was revealed when using a combined dose of both antioxidants at the same concentrations, times, and durations. A lower rate of free radical formation was also recorded, reflected by a reduction in superoxide dismutase (SOD) and glutathione peroxidase activity. The data here presented support the radioprotective role of both investigated antioxidants.

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“…Technetium‐99m as another gamma irradiating element has been used to induce the model of lens injury in rats. The oral administration of GBLE (0.11 mg/kg for 7 days before radiation) could compensate the lens‐related oxidative injuries induced by intravenous injection of 1 mCi of 99 mTc‐sestamibi (Khedr, Shafaa, Abdel‐Ghaffar, & Saleh, ). Raafat et al (2012) conducted another research with the similar method, but on the rat liver.…”

Section: Radiationmentioning

confidence: 99%

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

Omidkhoda

Razavi

Hosseinzadeh

2019

Phytotherapy Research

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Nowadays in our developing and industrial world, humans' health or even their life is threatened by exposure to poisons. In this situation, detecting a protective compound could be helpful and interesting. In the present article, we collected and reviewed all studies, which have been conducted so far about the protective effects of Ginkgo biloba L. (GB), one of the most ancient medicinal tree species, against toxicities induced by chemical toxic agents, natural toxins, and also radiation. In overall, investigations showed that GB exerts the antioxidant, antiinflammatory, antiapoptotic, and antigenotoxicity effects in different toxicities. There are also some special mechanisms about its protective effects against some specific toxic agents, such as acetylcholine esterase inhibition in the aluminium neurotoxicity or membrane‐bond phosphodiesterase activation in the triethyltin toxicity. Ginkgolide A was the most investigated active ingredient of G. biloba leaf extract as a protective compound against toxicities, which had the similar effects of total extract. A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. However, the promising effects of this valuable herbal extract will practically remain useless without carrying out more clinical studies and proving its effects on human beings.

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Radioprotective efficacy ofGinkgo bilobaandAngelica archangelicaextract against technetium-99m-sestamibi induced oxidative stress and lens injury in rats

Cited by 14 publications

References 40 publications

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

A Combined Protective Dose of Angelica archangelica and Ginkgo biloba Restores Normal Functional Hemoglobin Derivative Levels in Rabbits after Oxidative Stress Induced by Gallium-68

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

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