Radioprotective effect of hydrogen in cultured cells and mice

Qian, Liren; Cao, Fei; Cui, Jianguo; Huang, Yuecheng; Zhou, Xiao‐Jian; Liu, Shulin; Cai, Jianming

doi:10.3109/10715760903468758

Cited by 95 publications

(99 citation statements)

References 25 publications

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“…H 2 may also serve as an effective and safe radioprotective agent [374]. Despite a growing literature on the protective role of H 2 in various conditions, the chemical biology of H 2 requires further investigation to understand the underlying mechanisms at a molecular level.…”

Section: Carbon Monoxide and Hydrogenmentioning

confidence: 99%

Biological signaling by small inorganic molecules

Basudhar

Ridnour

Cheng

et al. 2016

Coordination Chemistry Reviews

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Small redox active molecules such as reactive nitrogen and oxygen species and hydrogen sulfide have emerged as important biological mediators that are involved in various physiological and pathophysiological processes. Advancement in understanding of cellular mechanisms that tightly regulate both generation and reactivity of these molecules is central to improved management of various disease states including cancer and cardiovascular dysfunction. Imbalance in the production of redox active molecules can lead to damage of critical cellular components such as cell membranes, proteins and DNA and thus may trigger the onset of disease. These small inorganic molecules react independently as well as in a concerted manner to mediate physiological responses. This review provides a general overview of the redox biology of these key molecules, their diverse chemistry relevant to physiological processes and their interrelated nature in cellular signaling.

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Section: Carbon Monoxide and Hydrogenmentioning

confidence: 99%

Biological signaling by small inorganic molecules

Basudhar

Ridnour

Cheng

et al. 2016

Coordination Chemistry Reviews

View full text Add to dashboard Cite

show abstract

“…Oxidative stress is thought to play a major role in cell damage following I/R injury and several studies have addressed whether H 2 administration can reduce I/R-induced cell 14 Nakao et sepsis, obstructive jaundice al., 15 Xie et al, 16 Liu et al 17 CAT Sepsis, obstructive jaundice Xie et al, 16 Liu et al 17 …”

Section: Ischaemia-reperfusion Injurymentioning

confidence: 99%

“…Cardinal et al, 25 Li et al, 26 chemotherapy complication, spinal Nagata et al, 27 Chen et cord injury al., 28 Ohsawa et al, 29 Liu et al, 17 Qian et al, 14 Nakashima-Kamimura et al, 30 Chen et al 31 …”

Section: Radiation Complication Qian Et Almentioning

confidence: 99%

Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

2010

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Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H 2 ) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H 2 (inhaled or orally ingested, typically as approximately 0.8 mM H 2 -saturated water), can exert beneficial effects in diverse animal models of ischaemia-reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H 2 -saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H 2 has selective antioxidant properties, and can exert antiapoptotic, antiinflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H 2 .

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“…Thereafter, accumulating evidence from animal studies indicated a protective effect of H 2 pretreatment on the progression of organ damage in various types of disease models , such as ischemia-induced injury and dysfunction of the brain [22,33,39,55,59,[62][63][64], heart [34,45,59,65], liver [30], retina [41], and kidney [59,60]; stress-induced hippocampus dysfunction [38]; cisplatinum nephropathy [37,44]; transplanted intestinal graft [31,47]; corneal alkali burn [51]; ouabain-induced auditory neuropathy [66]; lung injury by oxygen toxicity [43,46]; paraquat [52]; extensive burns [54]; chronic allograft nephropathy [48]; and radiation injuries in various organs [49,50,55,68,69]. In Parkinson's disease [36,40] and Alzheimer's disease models [42], H 2 ameliorates neurodegenerative changes in the brain.…”

Section: The Hydrogen Gas Molecule As a Biological Antioxidantmentioning

confidence: 99%

The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

2016

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Increased oxidative stress and pro-inflammatory conditions, commonly present in chronic dialysis patients, are thought to be enhanced during hemodialysis (HD) and to be associated with the excess morbidity and mortality seen in these patients. The hydrogen molecule (H 2 ) has a unique biological capacity to act as an antioxidative and anti-inflammatory substance. In light of accumulating evidence from animal studies showing protective effects against organ damage during ischemia and inflammation, development of H 2 treatments for HD patients has become a challenging clinical goal. An HD system utilizing a water electrolysis technique that renders large amounts of H 2 -enriched water has been developed. During HD with an H 2 -enriched solution (approximately 50 ppb H 2 ), markers of increased oxidative stress (such as interleukin-6, myeloperoxidase, methemoglobin, increased lymphocyte apoptosis, and high blood pressure) are suppressed. These findings indicate that the use of an H 2 -enriched solution may prove to be a novel approach to ameliorate dialysis-related complications. This manuscript reviews the recent progress in H 2 research and the use of H 2 in HD patients, including a description of a water electrolysis technique that delivers large amounts of H 2 -enriched water for use in clinical settings.

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Radioprotective effect of hydrogen in cultured cells and mice

Cited by 95 publications

References 25 publications

Biological signaling by small inorganic molecules

Biological signaling by small inorganic molecules

Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives

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