Radiopharmaceuticals and the gastrointestinal tract

Frier, M.; Perkins, Alan C.

doi:10.1007/bf00182360

Cited by 14 publications

(6 citation statements)

References 50 publications

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“…The main disadvantage of the use of 99m Tc is that 99m Tc pertechnetate is selectively concentrated in the stomach after oral or intravenous administration [15]. Therefore, it is important that there is high stability binding of the 99m Tc pertechnetate to the paediatric test meal [16]. The stability of binding is poor if the 99m Tc pertechnetate is simply mixed into the test meal [6].…”

Section: Technetium 99m-labelled Crispy Cakementioning

confidence: 99%

Gastric emptying of solids in normal children—a preliminary report

Singh¹,

Gibbons²,

Blackshaw³

et al. 2006

Journal of Pediatric Surgery

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Section: Technetium 99m-labelled Crispy Cakementioning

confidence: 99%

Gastric emptying of solids in normal children—a preliminary report

Singh¹,

Gibbons²,

Blackshaw³

et al. 2006

Journal of Pediatric Surgery

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“…At 08.30 hours the subject injected his usual morning dose of insulin subcutaneously (24 ± 17.6 IU, mean ± SD) and, at 09.00 hours, within 10 min, ate a test meal consisting of turkey, potatoes, vegetables (including mushrooms) and low-fat milkshake which provided 50 % carbohydrate (of which 70 % was starch), 35 % fat, 15 % protein with a total of 600 kcal. The mushrooms were labelled with 3 MBq non-absorbable 99m Tc tin colloid, and the milkshake with 0.5 MBq non-absorbable 111 In-DTPA-diethylenetriaminepentaacetic acid (DTPA) [6]. The milkshake also contained 3-OMG so that its appearance in the peripheral circulation could be used as an index of glucose absorption.…”

mentioning

confidence: 99%

Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM

Kong¹,

King²,

Macdonald

et al. 1997

Diabetologia

121

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Pramlintide, a human amylin analogue, reduces hyperglycaemia after meals in patients with insulin-dependent diabetes mellitus (IDDM). We investigated whether this was due to delayed gastric emptying. Eight men with uncomplicated IDDM were studied twice in a randomised, double-blind crossover design. Euglycaemia was maintained overnight by intravenous infusion of glucose and/or insulin and the following morning a 5-h infusion of pramlintide 25 micrograms/h or placebo was started at 08.00 hours. At 08.30 hours the patients injected their normal morning insulin dose subcutaneously and 30 min later ate a meal (600 kcal, 50% carbohydrate) of which the solid component was labelled with Technetium-99 m and the liquid with Indium-111 to quantify gastric emptying. Gamma-scintigraphic images were obtained every 20 min for the next 4 h. Insulin and glucose were infused as necessary to maintain blood glucose levels within 3 mmol/l of the pre-meal value. Compared to placebo, pramlintide significantly delayed emptying of both liquid (median lag time 69 vs 7.5 min) and solid (median lag time 150 vs 44.5 min) components of the meal. Pramlintide delayed gastric emptying so much that t50 values could not be calculated for solid or liquid. Amylin agonists such as pramlintide may, therefore, be of value in improving glycaemic control in IDDM by modifying gastric emptying.

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“…In 1989, Camilleri et al [3] from Mayo Clinic, USA, successfully developed a method of indium-111 (III) chloride ( 111 InCl 3 )-radiolabelled resin pellets for the assessment of gastric emptying and colonic transit. Amberlite IR-120 (H + ) cation resin pellets were successfully labelled with 111 InCl 3 , and this method has been widely practised in many centres, particularly for whole-gut transit studies [4][5][6][7]. This method, however, has certain limitations restricting its application to a broader population, mainly because of the requirement of an industrial cyclotron facility for the production of 111 In, which is not commonly available worldwide.…”

Section: Introductionmentioning

confidence: 98%

Neutron-activated 153Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy

Yeong

Abdullah

et al. 2011

Nuclear Medicine Communications

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Nuclear medicine techniques are well established for the investigation of gastrointestinal (GI) motility and transit. Ion-exchange resins radiolabelled with ⁹⁹mTc and ¹¹¹In are widely used as nonabsorbable radiopharmaceutical markers, with ¹¹¹In being preferred for whole-gut transit studies. This radionuclide, however, is not produced in many countries and may be expensive when obtained through international shipment. This study describes the use of neutron-activated ¹⁵³Sm-resin as an alternative tracer for use in GI scintigraphic investigation. A measure of 50 mg of stable samarium-152 chloride (¹⁵²SmCl₃) was incorporated into 100 mg of cation-exchange resin and irradiated in a neutron flux of 1 × 10¹³ cm⁻² s⁻¹ for 100 s to achieve an activity of 5 MBq after 66 h. Aliquots of ¹¹¹In-radiolabelled resin (5 MBq) were prepared for comparison of labelling and stability. Radiolabelling efficiencies were obtained by washing resin with distilled water, and the activity lost was measured. The radiolabelled resins were immersed in simulated gastric and intestinal fluid environments, and the retention of ¹⁵³Sm³⁺ and ¹¹¹In³⁺ was measured over a 24 h period. At 66 h after production, 91.15 ± 12.42% of ¹⁵³Sm was bound to the resin after washing in distilled water, whereas radiolabelling with ¹¹¹In achieved 99.96 ± 0.02% efficiency. Both radiolabelled resins demonstrated almost 100% stability in simulated intestinal fluid and >90% stability in artificial gastric juice over 24 h. The performance of neutron-activated ¹⁵³Sm-resin is similar to that of ¹¹¹In-resin and can be used as an alternative tracer for GI transit studies when In is not available.

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Radiopharmaceuticals and the gastrointestinal tract

Cited by 14 publications

References 50 publications

Gastric emptying of solids in normal children—a preliminary report

Gastric emptying of solids in normal children—a preliminary report

Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM

Neutron-activated 153Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy

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