Radionuclide scintigraphy in the evaluation of gastroesophageal reflux in symptomatic and asymptomatic pre-term infants

Morigeri, Chandrashekara; Bhattacharya, Anish; Mukhopadhyay, Kanya; Narang, Anil; Mittal, BR

doi:10.1007/s00259-008-0752-y

Cited by 25 publications

(14 citation statements)

References 14 publications

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“…In the literature, previous studies mentioned about relationship between reflux scintigraphy and clinical symptoms and role of the reflux in etiology of respiratory disease [3, 5]. According to our knowledge, although it is well known that growth and development are affected by clinically [3, 12-15].…”

Section: Discussionmentioning

confidence: 99%

The Scintigraphic Findings of Gastroesophageal Reflux in Children is Related to Body Weight?

et al. 2013

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BackgroundGastroesophageal reflux disease (GERD) is the most common cause of children admissions to pediatric gastroenterology unit and affects about 30% of pediatric population. Body weight and height percentiles of children with GERD and their relationship between presence and the severity of reflux on scintigraphic images were studied.MethodsPatients who underwent reflux scintigraphy between 2005 - 2012 were retrospectively reviewed. Among 200 patients, 49 patients were involved that their ages were ranging from 0 to 18 years old and body weight and height percentiles were recorded. Accurately 37 MBq (1 mCi) 99mTc-MAA in 100 - 150 mL of milk was ingested by the patient. Presence, number, duration and level of reflux were evaluated on the dynamic images. Presences of reflux within last ten minute were also recorded. Region-of-interests were drawn on esophagus and stomach and reflux ratio (RR) was calculated.ResultsThe ratio of the presence of reflux which occurred within the last ten minutes was significantly higher in children with low body weight percentile. High-level reflux frequency was higher in these children than in normal’s. Presence of reflux which occurred within the last ten minutes was related with low body weight percentile.ConclusionsIf reflux is shown within the last ten minutes and there is high level of reflux, the clinician should be warned about possible low body weight percentile in the future and scintigraphic study should be a guide or a reference for the assessment of more effective treatment methods.

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Section: Discussionmentioning

confidence: 99%

The Scintigraphic Findings of Gastroesophageal Reflux in Children is Related to Body Weight?

et al. 2013

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“…Accumulation of evidence regarding the determination of lipid-laden macrophages (LLM) in BAL resulted in the conclusion that this method lacks sensitivity and specificity [1]. More recent data show the presence of pepsin in BAL and middle ear fluid [1,74]. Also, bile salts are detected in middle ear fluid [80].…”

Section: Diagnosismentioning

confidence: 97%

“…One study evaluating nuclear scintigraphy with late imaging reported that 50 % of the patients with a variety of respiratory symptoms had pulmonary aspiration after 24 h [73]. However, later studies failed to reproduce these findings [74]. Aspiration also occurs in healthy subjects, especially during sleep [1].…”

Section: Ger(d) and Recurrent Pneumoniamentioning

confidence: 98%

Gastroesophageal Reflux

Vandenplas¹

2015

Textbook of Pediatric Gastroenterology, Hepatology and Nutrition

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“…GERD is considered common in premature infants younger than 34 weeks gestational age, but the severity of GERD is not significantly different in symptomatic and asymptomatic infants [37,40,50]. Some authors stated that GERD is common even in premature infants younger than 32 weeks gestational age [33,34,36,41,44].…”

Section: The Age Of the Premature Child When The Pattern Of Gerd Can mentioning

confidence: 99%

“…Other frequently documented symptoms of GERD were: coughing, "grunting" (labored breathing), recurrent attacks with cyanosis, arching, grimacing, crying, showing signs of irritability, discomfort and pain, and stretching out extremities [37][38][39][40]. Other studies describe some of these symptoms as not so common/more rare, like difficulty gaining weight/failure to thrive, desaturation, "choking", "gagging", chewing, refusing to eat, irritability, showing discomfort, grimacing, and arching, cough, yawning, hiccups and sneezing [41,42].…”

Section: Specific Symptoms Of Gerd In Premature Infantsmentioning

confidence: 99%

Development of an Observational Instrument to Assess Gastro-Esophageal Reflux Disease in Premature Infants

Sandberg

Öhman

2014

Int. J. Child Health Nutr.

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Background: Premature infants are at increased risk of developing Gastroesophageal Reflux Disease (GERD), which for these children is associated with a number of severe symptoms. There is great need for effective instruments and clear symptom criteria to assess the presence and degree of severity of GERD. Aim: To develop and pilot test an observation instrument for early detection of symptoms of GERD in premature infants. Method: A combination of three research methods was used – systematic literature review, observation instrument development and a pilot test. Results: The systematic review identified specific symptoms of GERD. The development of the observational instrument started with the establishment of concordance between the criteria of symptoms according to the literature review and to NIDCAP, “Newborn Individualized Developmental Care and Assessment Program”. In the pilot test the criteria of symptoms were revised by comparing the result and the criteria between infants that clinically were estimated to have had a reflux problem and the ones who did not. Conclusion: An observation instrument was developed. The clinical evaluation by a pilot test showed that the instrument could be useful to record significant symptoms and combinations of symptoms that may occur in premature infants assessed as having reflux problems.

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Radionuclide scintigraphy in the evaluation of gastroesophageal reflux in symptomatic and asymptomatic pre-term infants

Cited by 25 publications

References 14 publications

The Scintigraphic Findings of Gastroesophageal Reflux in Children is Related to Body Weight?

The Scintigraphic Findings of Gastroesophageal Reflux in Children is Related to Body Weight?

Gastroesophageal Reflux

Development of an Observational Instrument to Assess Gastro-Esophageal Reflux Disease in Premature Infants

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