Radionuclide-labeled red blood cells: Current status and future prospects

Srivastava, Suresh C.; Chervu, L. Rao

doi:10.1016/s0001-2998(84)80022-7

Cited by 75 publications

(27 citation statements)

References 44 publications

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Section: Methodsmentioning

confidence: 99%

“…(27)], (c) free 9mTc due to catabolism of rce cells by the liver or (d) 9'9Tc bound to hemoglobin released by hemolysis of labeled cells. In labeled cells, 97% of the "9ITc is attached to the heme or globin (27). The average activity in the bladder (normalized to the total activity) for SS4 cells 1-2 hr after injection was 8.5 ± 4.6% (n = 9) and by 2-4 hr had increased (a) and SS2 (e).…”

Section: Methodsmentioning

confidence: 99%

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Modeling sickle cell vasoocclusion in the rat leg: quantification of trapped sickle cells and correlation with 31P metabolic and 1H magnetic resonance imaging changes.

Fabry¹,

Rajanayagam²,

Fine³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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We have developed an animal model to elucidate the acute effects of perfusion abnormalities on muscle metabolism induced by different density-defined classes of erythrocytes isolated from sickle cell anemia patients. Technetium-99m (9"'Tc)-labeled, saline-washed normal (AA), homozygous sickle (SS), or high-density SS (SS4) erythrocytes were injected into the femoral artery of the rat and quantitative 99fTc imaging, 31p magnetic resonance spectroscopy by surface coil at 2 teslas, and 'H magnetic resonance imaging at 0.15 tesla were performed. Between 5 and 25 p1 of SS4 cells was trapped in the microcirculation of the thigh (or 1-6 X 107 cells per cubic centimeter of tissue). In contrast, fewer SS discocytes (SS2) or AA cells were trapped (an equivalent packed cell volume of less than 6.7 p1 and 0.3 pl, respectively). After injection of SS4 cells an initial increase in inorganic phosphate was observed in the region of the thigh served by the femoral artery, intracellular pH decreased, and subsequently the proton relaxation time T, reached a broad maximum at 18-28 hr. When T, obtained at this time was plotted against the volume of cells trapped, an increase of T, over the control value of411 ± 48 msec was found that was proportional to the number of cells trapped. We conclude that the densest SS cells are most effective at producing vasoocclusion. The extent of the change detected by 'H magnetic resonance imaging is dependent on the amount ofcells trapped in the microcirculation and the magnitude of the initial increase of inorganic phosphate.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Modeling sickle cell vasoocclusion in the rat leg: quantification of trapped sickle cells and correlation with 31P metabolic and 1H magnetic resonance imaging changes.

Fabry¹,

Rajanayagam²,

Fine³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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“…Commonly accepted per-millicurie dosimetry values are 55 mrads to the blood and 19 mrads to the whole body. 48,49 Dosimetry rates with the PNIS probe ( Figure 3) are approximately 300-fold less, due to the greater sensitivity, and the fractional amount of activity employed.…”

Section: Equilibrium Methodsmentioning

confidence: 99%

Use of radioactive tracers in the evaluation of penile hemodynamics: history, methodology and measurements

Zuckier

1997

Int J Impot Res

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Radionuclide tracer techniques are intimately associated with some of the early ground-breaking investigations in erectile dysfunction and have evolved along with the ®eld. At the present time, the various investigations can be grouped into four categories: labeled blood-pool; tracer washout; tracer washin and combined blood-poolatracer and tracer washout examinations. Blood pool studies are most useful in assessing the integrity of arterial in¯ow, but may also be used to generate indices of venous leak. A non-imaging version of the blood-pool test may represent a simple and cost-effective alternative. Washout of intracavernosal xenon during erection seems the most rigorous method of testing venous integrity. Washout using 99m Tc-labeled substances may emerge as a convenient alternative to the more technically dif®cult xenon examinations. Dual-isotope blood pool and washout examinations, though complicated, represent an ideal method of analyzing penile hemodynamics, with potential to contribute signi®cantly to the understanding of penile physiology. Development of improved pharmacologic stimuli and augmentation of testing protocols by intracavernosal pressure monitoring may further improve the utility of quantitative and physiologic nuclear medicine examinations in erectile dysfunction.

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“…Technetium-99m red blood cell venography is a simple, safe and useful test for diagnosing D V T of the lower limb [1]. In some patients, however, medications m a y interfere with the labelling process, decreasing the tagging efficiency [2]. The following case report demonstrates the scintigraphic findings in a patient who underwent R B C venography while receiving chemotherapy because of testicular seminoma.…”

Section: Introductionmentioning

confidence: 93%

Poor-quality red blood cell labelling with technetium-99m: case report and review of the literature

Adalet

Cantez

1994

Eur J Nucl Med

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Technetium-99m red blood cell (RBC) venography is a simple and sensitive technique for the diagnosis of deep vein thrombosis of the lower limb, but optimal labelling of the blood pool is essential for a diagnostic study. Here we report the case of a 44-year-old male with deep vein thrombosis of the right leg. RBC venography of the lower extremities showed poor labelling. In addition we review the literature on the subject.

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Radionuclide-labeled red blood cells: Current status and future prospects

Cited by 75 publications

References 44 publications

Modeling sickle cell vasoocclusion in the rat leg: quantification of trapped sickle cells and correlation with 31P metabolic and 1H magnetic resonance imaging changes.

Modeling sickle cell vasoocclusion in the rat leg: quantification of trapped sickle cells and correlation with 31P metabolic and 1H magnetic resonance imaging changes.

Use of radioactive tracers in the evaluation of penile hemodynamics: history, methodology and measurements

Poor-quality red blood cell labelling with technetium-99m: case report and review of the literature

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