Radiolysis of Solid Glycine

Meshitsuka, Gisuke; Shindo, Kotaro; Minegishi, Atsuko; Suguro, Hiroshi; Shinozaki, Yoshiharu

doi:10.1246/bcsj.37.928

Cited by 22 publications

(8 citation statements)

References 7 publications

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“…Radiolysis of simple a-amino acid, such as glycine, leads to deamination as a major chemical consequence in the solid state [33]. Foti et al [34] have studied the molecular alteration of glycine irradiated by 3 keV He ions using in situ IR spectroscopy.…”

Section: Comparison Of Solid and Solution State Radiolysismentioning

confidence: 99%

A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states

Ke¹,

Huang²,

Bingrong³

et al. 2010

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Comparison Of Solid and Solution State Radiolysismentioning

confidence: 99%

A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states

Ke¹,

Huang²,

Bingrong³

et al. 2010

Nuclear Instruments and Methods in Physics Research Section B:

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“…The analysis of the irradiation products of solid amino acids was previously carried out partly by mass spectrometry or chromatographically (Gottschall and Tolbert, 1968;Clark et al, 1970), and partly after dissolving the substance irradiated under vacuum in water (Dale et al, 1949;Tolbert et al, 1963;Meshitsuka et al, 1964;Minegishi et al, 1967;Garrison, 1972).…”

Section: Introductionmentioning

confidence: 99%

Selective radiolysis of enantiomers

Merwitz

1976

Radiat Environ Biophys

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“…1 wherein gaseous products, free radical intermediates, and stable diamagnetic products are appropriately distinguished. The degradation scheme has emerged from the work of several research groups and is based on ESR and mass spectroscopic data and on analysis of the stable radiation products by conventional chemical methods (10)(11)(12)(13). The free radical NH2CHCOOH (Fig.…”

mentioning

confidence: 99%

¹³ C nuclear magnetic resonance studies of radiation damage: Radiation-induced degradation of glycine

Box¹,

Lilga²,

Potienko³

1977

Proc. Natl. Acad. Sci. U.S.A.

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The stable products generated in polycrystalline glycine exposed to ionizing radiation and subsequently dissolved in water were identified by using 13C nuclear magnetic resonance spectroscopy. The study was done on isotopically enriched samples. The results can be correlated with the results of many other studies on irradiated glycine using other methods.Somewhat over two decades ago, Gordy and his collaborators (1), and independently Combrisson and Uebersfeld (2), introduced electron spin resonance (ESR) spectroscopy as a tool for investigating radiation damage in biological compounds. Since then ESR has been employed in innumerable studies of the free radical stages of radiation damage processes in a wide variety of compounds. The power of the ESR technique has been considerably augmented by ENDOR (electron nuclear double resonance) which can provide more exact measurements of the hyperfine couplings of the unpaired electron in a free radical (3). Even before the invention of ESR spectroscopy, mass spectroscopy had found application in radiation research for the analysis of gaseous products. In this communication, we wish to report how 13C nuclear magnetic resonance (NMR) spectroscopy compliments ESR-ENDOR spectroscopy and mass spectroscopy so that a complete description of radiation damage processes in irradiated solids can be obtained.Most of what is known about radiation damage mechanisms has been learned from studies on relatively simple model compounds, such as glycine, which has served as a model compound for numerous studies of radiation damage processes. Thus, mass spectrometer measurements have shown that CO2 and NH3 are produced when polycrystalline glycine is exposed to ionizing radiation. ESR-ENDOR spectroscopy has been essential for identifying the free radical stages of the radiation damage process. Since the initial report of free radical formation in irradiated glycine by the aforementioned investigators (2, 3), numerous additional ESR and ENDOR studies have been reported including many single-crystal studies wherein free radical identifications are more definitive (4-10). The use of isotopically labeled compounds has been an important factor in verifying the identity of certain free radical products by the ESR-ENDOR method. Unstable free radical products can be stabilized by maintaining the sample at sufficiently low temperature, thereby allowing the primary free radical stages of the radiation damage process to be studied. These methods are not applicable to detection of nonvolatile diamagnetic radiation products. It is in this respect that we have found 13C NMR spectroscopy extremely useful.The scheme proposed for the radiation-induced degradation of glycine is shown in Fig. 1 wherein gaseous products, free radical intermediates, and stable diamagnetic products are appropriately distinguished. The degradation scheme has emerged from the work of several research groups and is based on ESR and mass spectroscopic data and on analysis of the stable radiation products by conventional chem...

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Radiolysis of Solid Glycine

Cited by 22 publications

References 7 publications

A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states

A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states

Selective radiolysis of enantiomers

¹³ C nuclear magnetic resonance studies of radiation damage: Radiation-induced degradation of glycine

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Radiolysis of Solid Glycine

Cited by 22 publications

References 7 publications

A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states

A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states

Selective radiolysis of enantiomers

13 C nuclear magnetic resonance studies of radiation damage: Radiation-induced degradation of glycine

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¹³ C nuclear magnetic resonance studies of radiation damage: Radiation-induced degradation of glycine