Radiology methods of the sarcopenia diagnosis

Purpose: To develop a methodology for determining the muscle mass index (MMI) at the level of Th12 based on the computed tomography of the chest; to estimate the impact of MMI on the outcome of the COVID19 patients as a prognostic factor. Material and methods: The medical data and computed tomography of the chest of 247 patients with confirmed pneumonia caused by SARS-Cov2 were used. A technique has been developed for determining MMI based on the cross-sectional area of paraspinal muscles at the level of the Th12 vertebra and the length of the thoracic spine. A correlation analysis of MMI calculated based on the length of the thoracic spine MMI(L) and height MMI(H) was performed. A statistical analysis of the differences of the MMI(L) in the groups of male and female patients with fatal outcome and recovered, as well as younger and older than 65 years were performed. Results: A strong correlation was found between the MMI calculated on the basis of the length of the thoracic spine and height (r = 0.861, p <0.001). The age threshold, which was associated with an increase in the likelihood of death, in men was 60 years (Se 77.3 %, Sp 60.5 %, PPV 51.5 %, NPV 83.1 %, Youden's index 0.378, area under ROC- curve 0.728), in women 65 years old (Se 72.2 %, Sp 68.6 %, PPV 49.1 %, NPV 85.5 %, Youden's index 0.408, the area under the ROC curve 0.734). The odds ratio of death when the age thresholds are exceeded was 5.2 for men (95 % CI: 2.3 – 12.0), for women – 5.7 (95 % CI: 2.4 – 13.4). MMI(L) 3.37cm2/m2 is a threshold value, below which the probability of death in male patients under 60 years increased 26.3 times (95 % CI: 4.8 – 143.0). In female patients, there was no statistically significant threshold value of MMI(L), which would be associated with a higher risk of death. Conclusion: MMI, calculated at the level Th12 on the basis of the length of the thoracic spine, can be reliably used as a tool to estimate sarcopenia associated muscle atrophy, if there is no anthropometric data. The MMI(D) less than 3.37 cm2/m2 is a strong predictor of death in men under 60 years of age. Further work is needed to study the effect of sarcopenia on the severity and outcome of COVID19 in female patients, taking into account comorbid conditions.

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Muscle Mass Index at the Level Th12 vertebra as a Prognostic Factor for Fatal Outcome in the Patients with Pneumonia Caused by SARS-COV2

Башков

Сушков

Григорьева

et al. 2021

Medical Radiology and Radiation Safety

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Profile of a patient with stable coronary artery disease and impaired muscle status

Kokov

Масенко

Kareeva

et al. 2023

Cardiovasc Ther Prev

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Aim. To determine the clinical profile of a patient with stable coronary artery disease (CAD) and impaired muscle status.Material and methods. The study included 387 patients with stable CAD who had indications for open myocardial revascularization. Quantification of muscle tissue was carried out using computed tomography. Comparative analysis of clinical and anamnestic characteristics of groups of patients with sarcopenia (n=152) and those with normal muscle status (n=235) was performed.Results. Signs of sarcopenia were found in 39,3% of patients with stable CAD. In the group of sarcopenia and the group with normal muscle status, there was a predominance of males — 86,2 and 64,7% (p=0,01), the presence of hypercholesterolemia — 51,3 and 31,1% (p=0,02), type 2 diabetes — 21,1 and 28,1% (p=0,06), multivessel CAD — 25,6 and 17,8% of cases (p=0,018), respectively. In sarcopenia, a 4 times longer history of diabetes was noted (p=0,01) and a 2,3 times longer duration of CAD (p=0,03). The prevalence of obesity in sarcopenia was 3,4 times less (p=0,003). Correlation analysis showed the relationship of muscle status with age (r=-0,674; p=0,002), duration of CAD history (r=-0,582; p=0,001) and diabetes (r=-0,748; p<0,001).Conclusion. The clinical and anamnestic profile of a patient with stable CAD and sarcopenia is characterized by an association of decreased muscle mass with male sex, hypercholesterolemia, multivessel coronary CAD, a long-term history of type 2 diabetes and angina.

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Sarcopenic obesity: patterns and paradoxes

Драпкина¹,

Budnevsky²,

Ovsyannikov³

et al. 2021

Profil. med.

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Radiology methods of the sarcopenia diagnosis

Abstract: Информация о финансировании. Финансирование данной работы не проводилось. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

Cited by 7 publications

References 55 publications

Muscle Mass Index at the Level Th12 vertebra as a Prognostic Factor for Fatal Outcome in the Patients with Pneumonia Caused by SARS-COV2

Muscle Mass Index at the Level Th12 vertebra as a Prognostic Factor for Fatal Outcome in the Patients with Pneumonia Caused by SARS-COV2

Profile of a patient with stable coronary artery disease and impaired muscle status

Sarcopenic obesity: patterns and paradoxes

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