Radiological Workup of Cystic Neoplasms of the Pancreas

Bollen, Thomas L.; Wessels, Frank J.

doi:10.1159/000489674

Cited by 23 publications

(16 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pancreatic pseudocyst located at the head and uncinate process of the pancreas may mimic IPMN, especially when no history of pancreatitis is evident. The dilated main pancreatic duct, punctuate or coarse calcifications, and mural nodules are characteristic findings in main duct IPMN [ 17 ]. Branched duct IPMN gives a 'bunch of grapes' appearance on EUS, as the mucin-filled dilated branched ducts arrange themselves in pleomorphic pattern [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

An Atypical Presentation of Pancreatic Pseudocyst Masquerading as Solid Pseudopapillary Neoplasm of Pancreas

Choudhury

Mohanty

Mohapatra

et al. 2020

Cureus

View full text Add to dashboard Cite

Pancreatic pseudocysts are the most common cystic lesions of the pancreas, and often present as a consequence of acute or chronic pancreatitis. On the other hand, cystic neoplasms of the pancreas are rare, but pose a significant diagnostic challenge. The differentiation between these entities often relies on the clinical features and characteristic radiological evidence. However, the diagnostic dilemma persists, leading to misdiagnosis and inappropriate treatment. We present a case of pancreatic pseudocyst in a 49-year-old male, which clinically and radiologically mimicked solid pseudopapillary neoplasm, a rare type of cystic neoplasm of the pancreas.

show abstract

Section: Discussionmentioning

confidence: 99%

An Atypical Presentation of Pancreatic Pseudocyst Masquerading as Solid Pseudopapillary Neoplasm of Pancreas

Choudhury

Mohanty

Mohapatra

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…[ 16 ] The abdominal CT shows large size solitary lesion, heterogeneous density mass with occasional. [ 17 ] On MR, the papillary solid part T1WI appears as a low to iso-intensity and hyper to iso-intensity on T2WI moreover on contrast examination, the solid components display heterogeneous enhancement. [ 18 ]…”

Section: Differential Diagnosismentioning

confidence: 99%

Diagnosis and differentiation of mature cystic teratoma of pancreas from its mimics

Zhou

Kong²,

Valluru

et al. 2020

Medicine

View full text Add to dashboard Cite

Introduction: Mature cystic teratoma originating in the pancreas is very unusual, often observed as an incidental finding during routine examinations or recognized perioperatively as the patients present with very unspecific clinical symptoms. The confirmatory diagnosis of a pancreatic cystic teratoma is generally made by histopathology after surgical excision. So, the preoperative diagnosis is very challenging, especially differentiation from the other pancreatic pathologies. Patient concerns: A 23-year-old woman was admitted to our hospital with a complaint of mild grade periumbilical abdominal pain. A pancreatic mass was revealed on a preliminary abdominal ultrasound examination. Her medical history was unremarkable with no long-standing illness or malignancy. Diagnosis: Mature cystic teratoma in the head of the pancreas. Interventions: Roux-enY choledochojejunostomy with gastrojejunostomy was performed, excising the tumor from the pancreatic head. Outcomes: The postoperative course was uneventful; the patient was asymptomatic and has no evidence of recurrence on a 2-year follow up. Conclusions: Pancreatic cystic teratoma is a benign, well-differentiated, and extremely rare congenital tumor. MRI is the choice of imaging modality and phase-GRE or fat suppression is the best technique for pre-operative diagnosis.

show abstract

“…computerised tomography and endoscopic ultrasonographycan help point towards a diagnosis of SCA. 1,3 However, the gold standard for confirming this diagnosis is histopathological assessment, especially as there are SCA subtypes (e.g. solid and oligocystic), which can be difficult to radiologically distinguish from differential diagnoses.…”

Section: Introductionmentioning

confidence: 99%

“…solid and oligocystic), which can be difficult to radiologically distinguish from differential diagnoses. 3,4 Endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNAB) is currently the optimal method for tissue-sampling a pancreatic neoplasm. 1 There are microscopic features in an EUS-FNAB specimen which are usually sufficient to morphologically distinguish SCA from MCN and SPPN.…”

Section: Introductionmentioning

confidence: 99%

Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound‐guided aspiration/biopsy specimens

et al. 2021

View full text Add to dashboard Cite

Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound-guided aspiration/biopsy specimens Aims: Because serous cystadenoma (SCA) does not usually require excision, it is critical to distinguish it from differential diagnoses which do, especially neuroendocrine tumour (NET). The gold standard for diagnosing SCA is assessment of endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNAB) material. Inhibin immunohistochemistry aids this assessment, but such positivity is not absolutely sensitive or specific to SCA. The following is the largest known study of SCA EUS-FNAB specimens and the first to compare four potential SCA immunomarkers between themselves and inhibin, compared against NET. Methods and results: Immunohistochemistry for calponin, mucin 6 (MUC6), glucose transporter 1 (GLUT1) and vascular endothelial growth factor A (VEGFA) was performed on 30 EUS-FNAB and three resection specimens of SCA and 32 EUS-FNAB specimens of NET. GLUT1 and VEGFA were suboptimal as diagnostic immunomarkers of SCA, being expressed by 10 and 44% of NETs, respectively. Further, their expression by cellular constituents of blood which often contaminate EUS-FNAB specimens hampered identification of neoplastic cells, especially in hypocellular samples. While 19% of NETs showed nuclear MUC6 positivity, cytoplasmic expression of the protein showed 100% specificity and sensitivity as an SCA marker. However, assessing MUC6 in EUS-FNAB specimens must also consider the protein's focal expression in physiological pancreatic, gastric or duodenal tissues, which can contaminate these specimens. Calponin was less sensitive (71% versus 100%) but more specific (100% versus 91%) than inhibin, although easier to assess in EUS-FNAB specimens than MUC6. Conclusions: Of the four potential immunomarkers of SCA suggested by the existing literature, calponin and MUC6 are useful complementary studies to inhibin for application to EUS-FNAB specimens.

show abstract

Radiological Workup of Cystic Neoplasms of the Pancreas

Cited by 23 publications

References 64 publications

An Atypical Presentation of Pancreatic Pseudocyst Masquerading as Solid Pseudopapillary Neoplasm of Pancreas

An Atypical Presentation of Pancreatic Pseudocyst Masquerading as Solid Pseudopapillary Neoplasm of Pancreas

Diagnosis and differentiation of mature cystic teratoma of pancreas from its mimics

Calponin and MUC6 complement inhibin as diagnostic immunomarkers of serous cystadenoma in endoscopic ultrasound‐guided aspiration/biopsy specimens

Contact Info

Product

Resources

About