Radiological presentation of patients of pulmonary tuberculosis with diabetes mellitus

Patel, Anand; Rami, Kiran; Ghanchi, Feroz D

doi:10.4103/0970-2113.76308

Cited by 16 publications

(23 citation statements)

References 2 publications

(3 reference statements)

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“…A previous report in 2000 also demonstrated a higher lower-lung field involvement (Perez-Guzman et al, 2000, as cited in Patel et al,2011). Some investigators have demonstrated no major differences of the roentgenographic pictures (Bacakoglu et al, 2001, as cited in Patel et al,2011) while other previous studies have reported more common multiple cavities among diabetic patients (Sen et al, 2009, as cited in Patel et al,2011). There are not clear reasons for atypical images in TB patients with diabetes.…”

Section: Imagingmentioning

confidence: 70%

“…A recent study of TB patients with diabetes conducted in India revealed that lower lung field involvement was predominant (84%) as compared to upper lung field. Cavitation was predominantly confined to the lower lung field (80%) while nodular lesions were found in 36% and exudative lesions were found in 22% (Patel et al,2011). A previous report in 2000 also demonstrated a higher lower-lung field involvement (Perez-Guzman et al, 2000, as cited in Patel et al,2011).…”

Section: Imagingmentioning

confidence: 79%

“…Cavitation was predominantly confined to the lower lung field (80%) while nodular lesions were found in 36% and exudative lesions were found in 22% (Patel et al,2011). A previous report in 2000 also demonstrated a higher lower-lung field involvement (Perez-Guzman et al, 2000, as cited in Patel et al,2011). Some investigators have demonstrated no major differences of the roentgenographic pictures (Bacakoglu et al, 2001, as cited in Patel et al,2011) while other previous studies have reported more common multiple cavities among diabetic patients (Sen et al, 2009, as cited in Patel et al,2011).…”

Section: Imagingmentioning

confidence: 99%

See 2 more Smart Citations

Management of TB in HIV Subjects, the Experience in Thailand

Cheepsattayakorn¹

2012

Understanding Tuberculosis - Global Experiences and Innovative Approaches to the Diagnosis

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Section: Imagingmentioning

confidence: 70%

Section: Imagingmentioning

confidence: 79%

Section: Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Management of TB in HIV Subjects, the Experience in Thailand

Cheepsattayakorn¹

2012

Understanding Tuberculosis - Global Experiences and Innovative Approaches to the Diagnosis

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“…Promjene su podjednako zastupljene u oba plućna krila, a česte su konfluentne konsolidacije, pleuralne efuzije, hilarne limfadenopatije, te kaverne (pojedinačne ili multiple, prečnika i do 3 cm). Zbog takve "atipične" lokalizacije tuberkuloza u dijabetesu se često pogrešno dijagnostikuje kao pneumonija, karcinom ili apsces [5].…”

Section: Uvodunclassified

Poređenje karakteristika plućne tuberkuloze kod bolesnika sa i bez dijabetesa

Petrović¹,

Stojanović²,

Mavija

et al. 2017

Biomedicinska istraž.

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Kratak sadržajUvod. U svijetu se bilježi globalni porast oboljelih od tuberkuloze i dijabetesa. Bolesnici sa dijabetesom imaju dvostruko veći rizik oboljevanja od aktivne tuberkuloze, četiri puta veći rizik od recidiva tuberkuloze i dva puta veći rizik od smrti tokom liječenja tuberkuloze. Cilj rada je utvrditi učestalost atipične radiološke lokalizacije tuberkuloze i učestalost komorbiditeta, kao i potrebu za promjenom liječenja dijabetesa kod bolesnika sa tuberkulozom i dijabetesom u odnosu na bolesnike bez dijabetesa.Metode. Ispitivane su dvije grupe bolesnika: grupu 1 činilo je trideset bolesnika sa tuberkulozom i dijabetesom, a grupu 2 trideset bolesnika sa tuberkulozom bez dijabetesa. Retrospektivnom analizom medicinske dokumentacije bolesnika utvrđena je radiografska lokalizacija promjena na plućima, terapija dijabetesa, komorbiditeti i ishod liječenja.Rezultati. U grupi 1 na radiografiji pluća tipičnu rediografsku sliku i lokaliza ciju plućne tuberkuloze je imalo 30%, a atipičnu lokalizaciju 70% bolesnika, dok je u grupi 2 tipična lokalizacija utvrđena kod 33,3%, a atipična kod 66,7% bolesnika (p = 0,781). Prije prijema u bolnicu 60% bolesnika grupe 1 je liječeno oralnim antidijabeticima, 13,3% insulinom, a 26,7% dijetom. Poslije otpusta, oralnim antidijabeticima je liječeno 53,3% bolesnika, 36,7% insulinom, 10% dijetom. Najčešći komorbiditeti u grupi 1 bile su kardiovaskularne bolesti (56,6%) i hronična opstruktivna bolest pluća (30,0%), a u grupi 2 kardiovaskularne bolesti (33,3%), dok su hronična opstruktivna bolest pluća i anemija bile zastupljene u istom procentu od 16,6%. Ishod liječenja bolesnika dvije ispitivane grupe značajno se razlikovao. U grupi 1 izliječena su 24 bolesnika, a 6 bolesnika je umrlo, dok je u grupi 2 izliječeno 29, a umro 1 bolesnik (p = 0,044).Zaključak. Nije utvrđena značajna razlika u učestalosti atipične radiološke lokalizacije tuberkuloze ni u učestalosti komorbiditeta kod bolesnika sa dijabetesom i onih bez dijabetesa. Bolesnici sa dijabetesom zahtijevali su tokom liječenja tuberkuloze korekciju liječenja dijabetesa. Utvrđen je statistički značajno veći broj umrlih bolesnika u grupi sa tuberkulozom i dijabetesom u odnosu na onu bez dijabetesa.

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“…3 TB is a significant cause of mortality among immune compromised patients and continues to be a significant threat to humans globally. 4 Diabetes Mellitus (DM) was a known risk factor for TB in the past, but this was mostly neglected during the second half of the 20 th century with the advent of widely available treatment for both diseases. 5 In recent decades with the increasing prevalence of TB, particularly multi drug resistant TB and DM cases in the world, the relationship is re-emerging as a significant public health problem and is more challenging.…”

mentioning

confidence: 99%

An Observational Study to Determine the Impact of Glycaemic Control on Presentation of Drug Sensitive and Drug Resistant Pulmonary Tb in Type 2 Diabetes

Mahmood¹,

Verma²,

Ahmad³

et al. 2018

jemds

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BACKGROUND There is a strong correlation between the two diseases, diabetes and tuberculosis, with impact of one on the other. Poor glycaemic control causes poor outcome of tuberculosis treatment and that can be observed radiologically and microbiologically beside clinical observation.The aim of the study is to study the impact of glycemic control on presentation (clinical, radiological and microbiological) of drug sensitive and drug resistant pulmonary TB in type 2 diabetes. MATERIALS AND METHODSThis is an observational cross-sectional study. Patients above 18 years, having PTB with DM over one year were included. PTB with other conditions like HIV, Pregnancy, Connective tissue disorders, Chronic renal failure, Chronic liver disease, Malignancy, on longterm steroid use or cytotoxic drug therapy or on immunosuppressive drugs were not included in this study. Glycemic control was assessed by A1c < 7 as controlled and > 7 as uncontrolled. Clinical, Microbiological and Radiographic parameters of the patients were studied in respect to their glycemic control. RESULTS263 PTB patients who were screened for the study, out of which 94 were diabetic. The prevalence of D Min PTB patients was found to be 35.7% (out of 180 drug-sensitive PTB patients 68 were diabetic and out of 83 drug resistant PTB patients 26 were diabetic). The overall mean age was (50 ± 9) years, maximum no. of patients (60%) were in 40 -60 years' age group, 70% males with mean A1c (8.54 ± 0.03), 81% had uncontrolled glycemic status and 100% had cough with mean A1c (8.47 ± 0.03). 81% were sputum AFB positive with mean A1c (8.64 ± 0.014), 75.5% had lower lung field abnormalities with mean A1c (8.61 ± 0.094), 12.57% upper lung field with mean A1c (7.53 ± 0.012), 9.5% both lung fields with mean A1c (9.19 ± 0.082), 84% had infiltrative lesions with mean A1c (8.45 ± 0.017) and 25.5% had cavities with high mean A1c (10.04 ± 0.029). CONCLUSIONThe association between DM and TB is the most emerging challenge for global TB control. Poor glycemic control has significant effect on sputum smear positivity, more cavity formation and lower lung field involvement with no effect on clinical symptom. Hence, with the help of this study, it can be concluded that screening for DM should be performed routinely in patients with TB that may improve treatment outcomes. Submission 30-12-2017, Peer Review 27-01-2018, Acceptance 01-02-2018, Published 12-02-2018. Corresponding Author: Dr. Tariq Mahmood, Professor and HOD, Department of Pulmonary Medicine, MLN Medical College, Allahabad-211001, Uttar Pradesh, India. E-mail: mlnmctariqmahmood@gmail.com DOI: 10.14260/jemds/2018 An estimated 10.4 million people fell ill with TB in 2016: 90% were adults, 65% were male, 10% were people living with HIV (74% in Africa) and 56% were in five countries: India, Indonesia, China, the Philippines and Pakistan. Drugresistant TB is a continuing threat to world community. In 2016, there were 6 lakh new cases with resistance to rifampicin, the most effective first-line drug, of whi...

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Radiological presentation of patients of pulmonary tuberculosis with diabetes mellitus

Cited by 16 publications

References 2 publications

Management of TB in HIV Subjects, the Experience in Thailand

Management of TB in HIV Subjects, the Experience in Thailand

Poređenje karakteristika plućne tuberkuloze kod bolesnika sa i bez dijabetesa

An Observational Study to Determine the Impact of Glycaemic Control on Presentation of Drug Sensitive and Drug Resistant Pulmonary Tb in Type 2 Diabetes

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