Radiological and clinical difficulties in the management of chronic maxillary sinusitis in β Thalassemic paediatric patients

Mauro, Roberta Di; Greco, Laura; Melis, Milena; Manenti, Guglielmo; Floris, Roberto; Giacomini, P; Girolamo, Michele Di; Girolamo, Stefano Di

doi:10.1016/j.ijporl.2016.02.033

Cited by 4 publications

(1 citation statement)

References 34 publications

(26 reference statements)

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“…Changes in the sinuses are a classical x-ray finding in βTM not usually observed in other anemias. Increased incidence of sinonasal infections in βTM has been reported in the literature 30 .…”

Section: Facial Bonesmentioning

confidence: 97%

Skeletal radiological findings in thalassemia major

Adamopoulos¹,

Petrocheilou²

2020

JRPMS

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Skeletal changes in beta-thalassemia major (βTM) create a wide spectrum of bone radiographic features. The main pathology is extensive marrow proliferation due to ineffective erythropoiesis but the relative skeletal findings are encountered with a progressively reduced frequency and severity nowadays due to the regular hypertransfusion programs. The resulting hemosiderosis and particularly iron chelation therapy have been associated with dysplastic features which are found more often. Skeletal radiological appearances in βTM relate to a complex multifactorial pathogenesis (i.e. marrow expansion, direct iron and chelation toxicity, endocrine complications) and depend on the severity and duration of the disease, the type and effectiveness of treatment and the toxic effects of chelation therapy. Awareness of these findings is very important since early recognition can be an indicator for therapy adaptation.

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Section: Facial Bonesmentioning

confidence: 97%