Radiologic findings of osteoarticular infection in paracoccidioidomycosis

Monsignore, Lucas Moretti; Martínez, Roberto; Simão, Marcelo Novelino; Teixeira, Sara Reis; Elías, Jorge; Nogueira-Barbosa, Marcello Henrique

doi:10.1007/s00256-011-1214-3

Cited by 18 publications

(26 citation statements)

References 17 publications

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“…Other radiological findings, described in 19 cases of osteoarticular PCM as osteolytic lesions and marginal sclerosis, as described by MONSIGNORE et al. 25 , bone flattening 15 irregularities of the trabecular bone 23 , joint swelling and the destruction of articular cartilage, which were indistinguishable from other infectious processes 10 , were also present among our findings.…”

Section: Discussionsupporting

confidence: 85%

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DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Loth

Biazim

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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Paracoccidioidomycosis (PCM) is caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb) and corresponds to prevalent systemic mycosis in Latin America. The aim of the present work was to evaluate the dose response effect of the fungal yeast phase for the standardization of an experimental model of septic arthritis. The experiments were performed with groups of 14 rats that received doses of 103, 104 or 105 P. brasiliensis (Pb18) cells. The fungi were injected in 50 µL of phosphate-buffered saline (PBS) directly into the knee joints of the animals. The following parameters were analyzed in this work: the formation of swelling in knees infused with yeast cells and the radiological and anatomopathological alterations, besides antibody titer by ELISA. After 15 days of infection, signs of inflammation were evident. At 45 days, some features of damage and necrosis were observed in the articular cartilage. The systemic dissemination of the fungus was observed in 11% of the inoculated animals, and it was concluded that the experimental model is able to mimic articular PCM in humans and that the dose of 105 yeast cells can be used as standard in this model.

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Section: Discussionsupporting

confidence: 85%

“…MONSIGNORE et al 25 studied the radiological findings of 19 cases of osteoarticular PCM and reported that, in all cases, osteolytic lesions were found. Other studies have also reported that lytic bone lesions are a characteristic of radiological involvement 9,11 with or without marginal sclerosis 7,13 .…”

Section: Discussionmentioning

confidence: 99%

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Loth

Biazim

Santos

et al. 2014

Rev. Inst. Med. trop. S. Paulo

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“…These data reinforced the prevalence of bone involvement in association with the acute-sub acute forms of the disease. 41 …”

Section: Clinical Presentationmentioning

confidence: 99%

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Marques¹

2013

An. Bras. Dermatol.

114

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Paracoccidioidomycosis is an acute - to chronic systemic mycosis caused by fungi of the genus Paracoccidioides. Due to its frequent tegument clinical expression, paracoccidioidomycosis is an important disease for dermatologists, who must be up-to-date about it. This article focuses on recent epidemiological data and discusses the new insights coming from molecular studies, as well as those related to clinical, diagnostic and therapeutic aspects. In the latter section, we give particular attention to the guideline on paracoccidioidomycosis organized by specialists in this subject.

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“…In the disseminated form of paracoccidioidomycosis, osteoarticular involvement could reach up to 20% of cases [8], and some reports have found only bone involvement in the acute clinical form [16, 17]. These severe forms of this disease may be complicated to hypercalcemia and hemophagocytic syndromes [18].…”

Section: Discussionmentioning

confidence: 99%

“…The rates of osteoarticular involvement by P. brasiliensis are completely different between patients with acute and chronic infections, occurring almost exclusively in the acute/subacute clinical form [16]. …”

Section: Discussionmentioning

confidence: 99%

Overinfection byParacoccidioides brasiliensisin Gouty Crystal Arthritis

Bonilla-Abadía

Vélez

Zárate-Correa

et al. 2012

Case Reports in Medicine

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Paracoccidioidomycosis is an endemic South American systemic mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis (P. brasiliensis). The main clinical form of disease is pulmonary, but all organs may be involved. We report a case of overinfection by P. brasiliensis in chronic gouty arthritis affecting the proximal phalanx of the right hallux. The patient required proximal amputation and long-term antifungal therapy.

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Radiologic findings of osteoarticular infection in paracoccidioidomycosis

Cited by 18 publications

References 17 publications

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

DOSE RESPONSE EFFECT OF Paracoccidioides brasiliensis IN AN EXPERIMENTAL MODEL OF ARTHRITIS

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Overinfection byParacoccidioides brasiliensisin Gouty Crystal Arthritis

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