Radiologic assessment of age‐related knee joint space changes in women: A 4‐year longitudinal study

Gensburger, D.; Arlot, M.; Sornay‐Rendu, Elisabeth; Roux, Jean-Paul; Delmas, Pierre D.

doi:10.1002/art.24342

Cited by 33 publications

(33 citation statements)

References 36 publications

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“…They found that lateral compartment BMLs sustained after ACL rupture, completely resolved after 2 years in almost all patients but 34 % patients developed new BMLs over the 2-year follow-up period. In our study, there were no significant differences in the lateral compartment between the injured and the noninjured groups in both cohorts but we did see an approximate doubling of prevalence in the medial compartment, a site which is of greater relevance to OA in older adults [33]. Data from this study suggests that age may not play a major role in the association between knee injury and BMLs as we saw very similar trends in both cohorts at all sites.…”

Section: Discussionsupporting

confidence: 63%

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

et al. 2014

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The aim of this cross-sectional study was to describe the associations between history of knee injury and knee structure using magnetic resonance imaging (MRI). This study included two population-based samples: the Tasmanian Older Adult Cohort (TASOAC) study (n = 430; mean age, 63.0 years; range, 51-79 years; 51 % female) and the Offspring study (n = 372; mean age, 45.0 years; range, 26-61 years; 57.5 % female). In both studies, 1.5 T MRI scans of the right knee were performed to measure bone marrow lesions (BMLs), cartilage volume, tibial bone area, cartilage defects and meniscal pathology. History of knee injury was assessed using a self-administered questionnaire. The association between knee injury and knee structure was determined using multiple linear and log binomial regression models. Nineteen percent of the middle-aged and 12 % of the older adults reported a history of knee injury. In middle-aged adults, BML presence (prevalence ratio (PR) = 1.6 (95 % CI, 1.2; 2.1)), tibial bone area (difference of means (DM) = +86 (+23, +149)) and meniscal extrusion presence (PR = 2.7 (1.1, 6.8)) were significantly higher in those with knee injury. In older adults, cartilage defect presence (PR = 1.3 (1.0, 1.7)), lateral (DM = -265 (-439, -92)) and total tibial (DM = -325 (-600, -51)) cartilage volume, BML presence (PR = 1.4 (1.0, 1.9)) and tibial bone area (DM = +140 (+19, +260)) were significantly associated with knee injury. Meniscal tears showed no significant associations in either cohorts. The association between knee injury and MRI-assessed structural pathology in the knee joint is moderate and appears to be stronger in older adults compared to middle-aged adults.

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Section: Discussionsupporting

confidence: 63%

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

et al. 2014

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“…In addition, the chance of requiring TKA increased 13% for every year of age. Older age is the strongest predictor of radiographic joint space narrowing and the development of knee OA [35,39]. In this study, age is also a strong predictor of TKA use once symptomatic end-stage knee OA has developed, with younger persons less likely to undergo TKA.…”

Section: Discussionmentioning

confidence: 73%

Clinical predictors of elective total joint replacement in persons with end-stage knee osteoarthritis

Zeni

Axe

Snyder‐Mackler

2010

BMC Musculoskelet Disord

138

114

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BackgroundArthritis is a leading cause of disability in the United States. Total knee arthroplasty (TKA) has become the gold standard to manage the pain and disability associated with knee osteoarthritis (OA). Although more than 400 000 primary TKA surgeries are performed each year in the United States, not all individuals with knee OA elect to undergo the procedure. No clear consensus exists on criteria to determine who should undergo TKA. The purpose of this study was to determine which clinical factors will predict the decision to undergo TKA in individuals with end-stage knee OA. Knowledge of these factors will aid in clinical decision making for the timing of TKA.MethodsFunctional data from one hundred twenty persons with end-stage knee OA were obtained through a database. All of the individuals complained of knee pain during daily activities and had radiographic evidence of OA. Functional and clinical tests, collectively referred to as the Delaware Osteoarthritis Profile, were completed by a physical therapist. This profile consisted of measuring height, weight, quadriceps strength and active knee range of motion, while functional mobility was assessed using the Timed Up and Go (TUG) test and the Stair Climbing Task (SCT). Self-perceived functional ability was measured using the activities of daily living subscale of the Knee Outcome Survey (KOS-ADLS). A logistic regression model was used to identify variables predictive of TKA use.ResultsForty subjects (33%) underwent TKA within two years of evaluation. These subjects were significantly older and had significantly slower TUG and SCT times (p < 0.05). Persons that underwent TKA were also significantly weaker, had lower self-reported function and had less knee extension than persons who did not undergo TKA. No differences between groups were seen for BMI, gender, knee flexion ROM and unilateral versus bilateral joint disease. Using backward regression, age, knee extension ROM and KOS-ADLS together significantly predicted whether or not a person would undergo TKA (p ≤ 0.001, R2 = 0.403).ConclusionsYounger patients with full knee ROM who have a higher self-perception of function are less likely to undergo TKA. Physicians and clinicians should be aware that potentially modifiable factors, such as knee ROM can be addressed to potentially postpone the need for TKA.

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“…Two-thirds of individuals with isolated ACL injury seem to have good long-term radiographic outcome, suggesting our focus should not only be on ACL injury prevention programs 52 , but also secondary injury prevention programs after ACLR. Very few studies have prospectively evaluated aged-related changes in OA 12 , but studies have shown significant decrease in joint space width (JSW) with older age 16 . In the uninjured contralateral knee in the current study, the rate of radiographic TF OA increased from 4% to 13% over the 5 years follow-up (Table 3a), indicating also a significant deterioration over time for the uninjured knee.…”

Section: Discussionmentioning

confidence: 99%

Changes in Knee Osteoarthritis, Symptoms, and Function After Anterior Cruciate Ligament Reconstruction

et al. 2016

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Background: Progression of tibiofemoral (TF) and patellofemoral (PF) osteoarthritis (OA) and changes in knee function more than 15 years after anterior cruciate ligament reconstruction (ACLR) are not well understood. Purpose: To examine the progression of knee OA and changes in symptoms and function in isolated and combined injuries from 15 to 20 years after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 210 subjects with ACLR were prospectively followed. At the 15- and 20-year follow-ups, radiographs were obtained and classified by the Kellgren and Lawrence (K-L) grading system. Symptoms and function were evaluated with the Knee injury and Osteoarthritis Outcome Score (KOOS) as well as isokinetic quadriceps and hamstring muscle strength tests. Results: There were 168 subjects (80%) who returned for the 20-year follow-up, with a mean (±SD) age of 45 ± 9 years, mean body mass index of 27 ± 4, and median Tegner activity level of 4 (range, 0-9). The prevalence of radiographic TF and PF OA at the 20-year follow-up was 42% and 21%, respectively. Patients with ACL injuries and other combined injuries had significantly higher prevalence of radiographic TF OA compared with those who had isolated ACL injury ( P < .0001). There was a 13% increase in radiographic TF OA ( P = .001) and an 8% increase in PF OA ( P = .015) from the 15- to the 20-year follow-up. A significant deterioration in knee symptoms and function was observed on the KOOS subscales ( P ≤ .01), with the exception of quality of life ( P = .14), as well as a decrease in quadriceps muscle strength and hamstring muscle strength ( P < .0001). Conclusion: The prevalence of radiographic TF and PF OA was 42% and 21%, respectively. A significantly higher prevalence of TF OA was found for subjects with combined injuries compared with those who had isolated ACL injury. The majority of the subjects were stable radiographically over the 5 years between follow-ups. A statistically significant deterioration in symptoms and function was noted, but the mean changes were of questionable clinical importance.

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Radiologic assessment of age‐related knee joint space changes in women: A 4‐year longitudinal study

Cited by 33 publications

References 36 publications

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

Clinical predictors of elective total joint replacement in persons with end-stage knee osteoarthritis

Changes in Knee Osteoarthritis, Symptoms, and Function After Anterior Cruciate Ligament Reconstruction

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