History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

Khan, Hussain; Aitken, Dawn; Blizzard, Leigh; Ding, Changhai; Pelletier, Jean‐Pierre; Pelletier, Johanne Martel; Cicuttini, Flavia Maria; Jones, Graeme

doi:10.1007/s10067-014-2758-0

Cited by 5 publications

(3 citation statements)

References 39 publications

(45 reference statements)

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“…We found that age was associated with increased risk of BMLs, which is consistent with a finding in a non-OA population cohort [ 37 ]. Injury was associated with medial tibiofemoral BMLs, which is in line with the finding observed in middle-aged and older adults [ 38 ]. However, BMI was not significantly associated with BMLs in this young cohort.…”

Section: Discussionsupporting

confidence: 88%

Correlates of knee bone marrow lesions in younger adults

Antony¹,

Venn²,

Cicuttini³

et al. 2016

Arthritis Res Ther

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BackgroundSubchondral bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain and structural progression in knee OA. However, little is known about clinical significance and determinants of BMLs of the knee joint in younger adults. We aimed to describe the prevalence and environmental (physical activity), structural (cartilage defects, meniscal lesions) and clinical (pain, stiffness, physical dysfunction) correlates of BMLs in younger adults and to determine whether cholesterol levels measured 5 years prior were associated with current BMLs in young adults.MethodsSubjects broadly representative of the Australian young adult population (n = 328, aged 31–41 years, female 48.7 %) underwent T1- and proton density-weighted fat-suppressed magnetic resonance imaging (MRI) in their dominant knee. BMLs, cartilage defects, meniscal lesions and cartilage volume were measured. Knee pain was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and physical activity was measured by the International Physical Activity Questionnaire (IPAQ). Cholesterol levels including high-density lipoprotein (HDL) were assessed 5 years prior to MRI.ResultsThe overall prevalence of BML was 17 % (grade 1: 10.7 %, grade 2: 4.3 %, grade 3: 1.8 %). BML was positively associated with increasing age and previous knee injury but not body mass index. Moderate physical activity (prevalence ratio (PR):0.93, 95 % CI: 0.87, 0.99) and HDL cholesterol (PR:0.36, 95 % CI: 0.15, 0.87) were negatively associated with BML, while vigorous activity (PR:1.02, 95 % CI: 1.01, 1.03) was positively associated with medial tibiofemoral BMLs. BMLs were associated with more severe total WOMAC knee pain (>5 vs ≤5, PR:1.05, 95 % CI: 1.02, 1.09) and WOMAC dysfunction (PR:1.75, 95 % CI: 1.07, 2.89), total knee cartilage defects (PR:2.65, 95 % CI: 1.47, 4.80) and total meniscal lesion score (PR:1.92, 95 % CI: 1.13, 3.28).ConclusionsBMLs in young adults are associated with knee symptoms and knee structural lesions. Moderate physical activity and HDL cholesterol are beneficially associated with BMLs; in contrast, vigorous physical activity is weakly but positively associated with medial tibiofemoral BMLs.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-016-0938-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 88%

Correlates of knee bone marrow lesions in younger adults

Antony¹,

Venn²,

Cicuttini³

et al. 2016

Arthritis Res Ther

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“…History of knee injury (e.g. ACL rupture) has been associated with tibiofemoral BMLs [17]. Biomechanical alterations were persistent even after ACL reconstruction [18], and therefore the altered biomechanical forces might be involved in incident or enlarging subchondral BMLs.…”

Section: Discussionmentioning

confidence: 99%

Association of subchondral bone marrow lesion localisation with weight bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative

Aso

Shahtaheri

McWilliams

et al. 2021

Preprint

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Background Subchondral bone marrow lesions (BMLs) detected on MRI in knee osteoarthritis (OA) are associated with knee pain. The prevalence and progression of subchondral BMLs are increased by mechanical knee load. However, associations of subchondral BML location with weight-bearing knee pain are currently unknown. In this study, we aim to demonstrate associations of subchondral BML location and size with weight-bearing knee pain in knee OA.Methods We analyzed 1412 and 582 varus knees from cross-sectional and longitudinal Osteoarthritis Initiative datasets, respectively. BML scores were semi-quantitatively analysed with the MRI Osteoarthritis Knee Score for 4 subchondral regions (median and lateral femorotibial, medial and lateral patellofemoral) and subspinous region. Weight-bearing and non-weight-bearing pain scores were derived from WOMAC pain items. Correlation and negative binomial regression models were used for analysis of associations between the BML scores and pain at baseline, and changes in the BML scores and changes in pain after 24-month follow up.Results Greater BML scores at medial femorotibial and lateral patellofemoral compartments were associated with greater weight-bearing pain scores, and statistical significance was retained after adjusting for BML scores at the other 4 joint compartments and other OA features, as well as for non-weight-bearing pain, age, sex and Body Mass Index (BMI) (medial femorotibial; B=0.08, p=0.02. patellofemoral; B=0.13, p=0.01). Subanalysis revealed that greater medial femorotibial BML scores were associated with greater pain on walking and standing (B=0.11, p=0.01, and B=0.10, p=0.04, respectively). Lateral patellofemoral BML scores were associated with pain on climbing, respectively B=0.14, p=0.02. Increases or decreases over 24 months in BML score in the medial femorotibial compartment were significantly associated with increases or decreases in weight-bearing pain severity after adjusting for non-weight-bearing pain, age, sex, baseline weight-bearing pain, BMI, and BML at the other 4 joint compartments (B=0.10, p=0.01). Conclusions Subchondral BML size at the medial femorotibial joint compartment was specifically associated with the severity and the change in weight-bearing pain, independent of non-weight-bearing pain, in knee OA. Specific associations of weight-bearing pain with subchondral BMLs in weight-bearing compartments of the knee indicate that BMLs in subchondral bone contribute to biomechanically-induced OA pain.

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“…History of knee joint injury was assessed using a self-administered questionnaire [ 11 ] which included the following questions: “Have you ever had a previous knee injury which resulted in non-weight bearing treatment for 24 h or more?” “If yes, then which knee?” “Please provide further details about the injury” …”

Section: Methodsmentioning

confidence: 99%

Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort

Khan

Aitken

Ding

et al. 2016

BMC Musculoskelet Disord

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BackgroundThere is limited longitudinal data available on the natural history of meniscal tears especially in middle-aged adults with a low prevalence of osteoarthritis (OA). The aim of this study was to describe the natural history of meniscal tears over 8 years and the relationship with change in knee pain and structures.MethodsOne hundred ninety eight participants [mean age 47 (28–63); 57 % female] were studied at baseline and 8 years later. Approximately half were the adult offspring of subjects who had a knee replacement performed for knee OA and the remainder were randomly selected controls. Meniscal tears/extrusion, cartilage volume/defects, bone marrow lesions (BMLs) and effusion were assessed on MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index.Results22 % of the participants had at least one meniscal tear at any site at baseline. Over 8 years, 16 % of the participants had an increase in severity of meniscal tears while none improved. Increase in meniscal tear score was associated with worsening knee pain (β = +2.81 (+1.40, +4.22)), with offspring having a significantly greater increase in pain severity compared to controls. BMI and presence of osteophytes at baseline, but not knee injury, predicted change in tears, whereas change in meniscal tears was independently associated with cartilage volume loss, change in BMLs and change in meniscal extrusion.ConclusionChange in meniscal tears shares risk factors with knee OA and is independently associated with worsening knee pain and structural damage suggesting that meniscal tears are on the knee OA causal pathway.

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History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study

Cited by 5 publications

References 39 publications

Correlates of knee bone marrow lesions in younger adults

Correlates of knee bone marrow lesions in younger adults

Association of subchondral bone marrow lesion localisation with weight bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative

Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort

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