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with increasing pain severity. In participants without pain, there were no major differences in PSS between people that did or did not perform sports. In contrast, in participants that did have current pain, performing sports revealed a lower PSS than not performing sports in both genders. The different films did not affect the pain sensitivity score in male participants. In females the film with laughing people led to a slightly lower PSS. However, the largest effect of film was observed in females who saw a film with people in pain. This led to an unexpected lower PSS than in females who did not see a film (55 vs 63, p<0,000). Conclusions: Our Dutch population study revealed that current pain had the largest impact on pain sensitivity. This effect was even larger in women as compared to men. We showed that females have a higher pain sensitivity than males. Importantly, our study shows that performing sports is related to lower pain sensitivity in people with pain. In females we found that changing environmental factors might be of larger benefit to influence pain than in males, as shown by the effect of watching different short films prior to filling out the questionnaires. In conclusion, our study shows that indeed pain severity has a major impact on pain sensitivity, but pain sensitivity is also subject to other factors like for example gender and sports. The latter strengthens findings of positive effects of sports that were found in OA pain as well. In females there is an added complexity due to a larger effect of external stimuli on pain sensitivity. Together with the differences in pain sensitivity between males and females this underlines the importance of gender differentiation in pain research.Purpose: Subchondral bone contributes to pain in knee osteoarthritis (OA). OA structural change particularly affects weight-bearing components of the joint, most notably the medial femorotibial compartment in people with varus angulation. Subchondral bone marrow lesions (BMLs) detected on MRI in knee OA are strongly associated with pain. BMLs typically occur in regions of the joint with the most severe structural change, for example, full-thickness cartilage lesions. However, the association between subchondral BMLs in weight-bearing components and weight-bearing pain has not been clarified. The purpose of this study was to assess association between BMLs location and weight bearing knee pain using data from the Osteoarthritis Initiative (OAI). We hypothesized that BMLs at the medial femorotibial joint compartment were associated with weight bearing pain, independent of non-weight bearing pain, and that changes in size of the BMLs over time were associated with change in weight bearing pain. Methods: The OAI is a publicly available multi-center, longitudinal, prospective observational study of knee OA. We examined the knees of OAI participants with MRI readings using the MRI Osteoarthritis Knee Score (MOAKS). BMLs, articular cartilage, osteophytes, Hoffa's synovitis, effusion, meniscal morphology and anterior cru...