Radiologic and clinical changes after denosumab treatment for giant cell tumors of the mobile spine: a quantitative study

Yuan, Bei; Han, Seung-Beom; Yang, Shi; Zhang, Lihua; Jiang, Liang; Wei, Feng; Yuan, Huishu; Liu, Xiaoguang; Liu, Zhongjun

doi:10.1186/s13244-022-01226-3

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…30 ). T2WI typically reveals a low-signal-intensity lesion [ 95 ]. GCTs can contain necrosis and haemorrhages with fluid–fluid levels or cystic areas with high intensity on T1WI and T2WI.…”

Section: Epidemiology and Imaging Features Of Spinal Bone Tumours Wit...mentioning

confidence: 99%

Understanding a mass in the paraspinal region: an anatomical approach

Creze,

Ghaouche,

Missenard

et al. 2023

Insights Imaging

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The paraspinal region encompasses all tissues around the spine. The regional anatomy is complex and includes the paraspinal muscles, spinal nerves, sympathetic chains, Batson’s venous plexus and a rich arterial network. A wide variety of pathologies can occur in the paraspinal region, originating either from paraspinal soft tissues or the vertebral column. The most common paraspinal benign neoplasms include lipomas, fibroblastic tumours and benign peripheral nerve sheath tumours. Tumour-like masses such as haematomas, extramedullary haematopoiesis or abscesses should be considered in patients with suggestive medical histories. Malignant neoplasms are less frequent than benign processes and include liposarcomas and undifferentiated sarcomas. Secondary and primary spinal tumours may present as midline expansile soft tissue masses invading the adjacent paraspinal region. Knowledge of the anatomy of the paraspinal region is of major importance since it allows understanding of the complex locoregional tumour spread that can occur via many adipose corridors, haematogenous pathways and direct contact. Paraspinal tumours can extend into other anatomical regions, such as the retroperitoneum, pleura, posterior mediastinum, intercostal space or extradural neural axis compartment. Imaging plays a crucial role in formulating a hypothesis regarding the aetiology of the mass and tumour staging, which informs preoperative planning. Understanding the complex relationship between the different elements and the imaging features of common paraspinal masses is fundamental to achieving a correct diagnosis and adequate patient management. This review gives an overview of the anatomy of the paraspinal region and describes imaging features of the main tumours and tumour-like lesions that occur in the region.

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Section: Epidemiology and Imaging Features Of Spinal Bone Tumours Wit...mentioning

confidence: 99%

Understanding a mass in the paraspinal region: an anatomical approach

Creze,

Ghaouche,

Missenard

et al. 2023

Insights Imaging

View full text Add to dashboard Cite

show abstract

“…This information provides a basis for practicians to perform short-term PATD [ 27 ]. CT, magnetic resonance imaging (MRI), and positron emission tomography (PET) are useful for evaluating tumor response [ 52 , 53 ] and blood supply. Based on the inverse Choi density/size (ICDS) criteria assessed using CT or MRI images before and after treatment with denosumab, the majority of patients with GCTB have a significant tumor response [ 54 ].…”

Section: Dose and Duration Of Therapy With Denosumab Affect The Blood...mentioning

confidence: 99%

Progress on Denosumab Use in Giant Cell Tumor of Bone: Dose and Duration of Therapy

Xiang

Liu

Deng

et al. 2022

Cancers

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Giant cell tumor of bone (GCTB) is an aggressive non-cancerous bone tumor associated with risks of sarcoma and metastasis. Once malignancy occurs, the prognosis is generally poor. Surgery remains the main treatment for GCTB. Multidisciplinary management is a feasible option for patients wherein surgical resection is not an option or for those with serious surgery-related complications. Denosumab is an anti-nuclear factor kappa B ligand approved for the treatment of postmenopausal women with osteoporosis, bone metastases, and advanced or inoperable GCTB. However, the guidelines for treating GCTB are unclear; its short-term efficacy and safety in inoperable patients have been demonstrated. Lengthier therapies (high cumulative doses) or pre-operative adjuvant therapy may be associated with severe complications and high local recurrence rates. Short-term administration helps attain satisfactory local control and functionality. As a result, lately, the impact of different doses and lengths of treatment on the efficacy of denosumab in GCTB treatment, the incidence of complications, and recurrence rates have gained attention. The efficacy and safety of denosumab against GCTB, its impact on imaging assessment, related complications, and recurrence of GCTB were previously reviewed. For further research direction, this paper reviews the progress of studies evaluating the impact of the dose and duration of denosumab therapy for GCTB.

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Radiologic and clinical changes after denosumab treatment for giant cell tumors of the mobile spine: a quantitative study

Cited by 2 publications

References 22 publications

Understanding a mass in the paraspinal region: an anatomical approach

Understanding a mass in the paraspinal region: an anatomical approach

Progress on Denosumab Use in Giant Cell Tumor of Bone: Dose and Duration of Therapy

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