Radiolabelled Nanoparticles for Diagnosis and Treatment of Cancer

“…In recent years an increasing variety of engineered nanomaterials, including those that are radioactive, have been developed and manufactured (Chopra, 2011;Farokzad and Langer, 2009;Hodge et al, 2010;Schug et al, 2013;Tinkle, 2010). These engineered nanomaterials are being used in a broad range of medical, industrial, educational and consumer products; and their use is rapidly expanding.…”

Section: Introductionmentioning

confidence: 99%

Radiation Safety Aspects of Nanotechnology

Hoover¹,

Myers²,

Cash³

et al. 2017

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LEGAL NOTICE This Report was prepared by the National Council on Radiation Protection and Measurements (NCRP). The Council strives to provide accurate, complete and useful information in its documents. However, neither NCRP, the members of NCRP, other persons contributing to or assisting in the preparation of this Report, nor any person acting on the behalf of any of these parties: (a) makes any warranty or representation, express or implied, with respect to the accuracy, completeness or usefulness of the information contained in this Report, or that the use of any information, method or process disclosed in this Report may not infringe on privately owned rights; or (b) assumes any liability with respect to the use of, or for damages resulting from the use of any information, method or process disclosed in this Report, under the Civil Rights Act of 1964, Section 701 et seq. as amended 42 U.S.C. Section 2000e et seq. (Title VII) or any other statutory or common law theory governing liability. Disclaimer Any mention of commercial products within NCRP publications is for information only; it does not imply recommendation or endorsement by NCRP.

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“…Hypoxic cells are resistant to radiation whether externally or internally. One of pathophysiological characteristics of tumors is rapid vascularization with poor lymphatic drainage which makes them accessible for targeting agents (1)(2)(3). Enzymes (4,5), receptors (6,7) and factors (8,9) which are more expressed in cancerous cells can be restrained by various inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation

2016

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Receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. Specific tumor-targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. Pharmacokinetics and bioavailability of diagnostic and therapeutic agents are very important. Poor selectivity of cancer therapeutic agents causes toxicity on normal cells that limits maximum effective dose. The Attachment of these agents to macromolecules or their installation on carriers is currently under investigation. This article presents recent developments in the field of targeting agents and introduces different carriers and their applications in the diagnosis and treatment of cancer.

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Radiolabelled Nanoparticles for Diagnosis and Treatment of Cancer

Cited by 5 publications

References 111 publications

Dilute lattice doping of ⁶⁴Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging

Dilute lattice doping of ⁶⁴Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging

Radiation Safety Aspects of Nanotechnology

Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation

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Radiolabelled Nanoparticles for Diagnosis and Treatment of Cancer

Cited by 5 publications

References 111 publications

Dilute lattice doping of 64Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging

Dilute lattice doping of 64Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging

Radiation Safety Aspects of Nanotechnology

Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation

Contact Info

Product

Resources

About

Dilute lattice doping of ⁶⁴Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging

Dilute lattice doping of ⁶⁴Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging