Dilute lattice doping of ⁶⁴Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging

Abstract

Quintinite nanoplate (64Cu-QT-NP) isomorphically substituted with 64Cu, as the positron emission tomography (PET) imaging material, was prepared via two-step processes. The 64Cu labeling efficiency of 99% was realized, for the...

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

“…This section focuses on recent (published from 2019 to 2023) in-vitro and in-vivo studies [ 49 ] on fluorescence imaging [ 78 ], magnetic resonance imaging (MRI) [ 79 ], and positron emission tomography (PET) [ 28 ] without any therapeutic molecules ( Figure 7 ). Functional LDH nanohybrids for bio-imaging applications are of three main types: First, an intercalation type, in which an MRI-active or fluorescent substance, such as FITC [ 32 , 80 ], Gd(III) complex [ 81 ], or diethylenetriamine pentaacetic acid (Gd-DTPA) [ 82 , 83 ], is intercalated into the LDH interlayer spaces.…”

“…PET, a molecule-based noninvasive diagnostic imaging method with excellent sensitivity, is particularly suitable for obtaining functional information about slight changes in disease biomarkers in in-vivo systems without any tissue penetration limit [ 28 , 104 , 105 ].…”

“…To overcome these limitations, Choy’s group has reported the use of 64 Cu as a tracing agent; it is suitable for PET imaging owing to its relatively long half-life (12.7 h), decay by multiple pathways including β + energy emission (18%), and high production yield and purity [ 28 ]. As illustrated in Figure 9 a, chemically stable 64 Cu-labeled quintinite nanoplate (QT-NP) are synthesized by coprecipitation and subsequent hydrothermal treatment (to immobilize 64 Cu 2+ ion into the octahedral sites of quintinite in a ratio that is different from that in naturally existing LDHs), followed by coating with BSA (for enhancing their stability during blood-stream circulation).…”

“…The application images are reprinted with permission from Refs. [ 27 , 28 , 29 ], Copyright 2022, Elsevier; Copyright 2022, the Royal Society of Chemistry; and Copyright 2020, Elsevier, respectively.…”

“…[ 79 ], Copyright 2019, the American Chemical Society), and positron emission tomography imaging (reprinted with permission from Ref. [ 28 ], Copyright 2022, the Royal Society of Chemistry).…”