Radioiodine treatment of Plummer's disease

Abstract

The presented overview summarizes the results of radioiodine treatment in patients with different forms of Plummer's disease. From the beginning the outcome defined as elimination of autonomy was excellent in the unifocal autonomous adenomas, but unsatisfactory in multifocal and disseminated autonomy using a fixed dose concept. The "dosimetric compromise" (= reducing the dose and defining the total gland as the target volume) yielded in these two variants of autonomy satisfactory results comparable to those of the unifocal form, since the dose was chosen according to the amount of functional autonomy measured by the Tc-99m-uptake in the thyroid gland under TSH-suppression.

A dosing algorithm for individualized radioiodine treatment of cats with hyperthyroidism

“…In human patients with toxic nodular goiter (most similar to the feline disease 44 ), some investigators have added TcTU measurements to the 131 I dosing protocol to increase efficacy of treatment. 45 , 46 , 47 , 48 Because TcTU provides useful quantitative information concerning the overall functional and metabolic activity of the toxic nodular goiter tissue in both hyperthyroid humans and cats, 20 , 45 , 46 , 47 , 48 we included TcTU as a marker of disease severity for our individual 131 I dose calculations in this study.…”

Evaluation of Quantitative Thyroid Scintigraphy for Diagnosis and Staging of Disease Severity in Cats With Hyperthyroidism: Comparison of the Percent Thyroidal Uptake of Pertechnetate to Thyroid‐to‐salivary Ratio and Thyroid‐to‐background Ratios

“…Rather, these calculations are generally based on an estimation of thyroid volume, thyroid 131 I uptake, and 131 I retention time within the thyroid gland . In human patients with toxic nodular goiter (most similar to the feline disease), investigators have reported the usefulness of adding TcTU measurements to the 131 I dose protocols to increase efficacy of treatment . In addition, TcTU may also play a prognostic factor for predicting 131 I treatment outcome (i.e., euthyroid, hypothyroid, persistent hyperthyroidism); in one study, the finding of high TcTU was predictive for treatment failure when a fixed dose 131 I method was used .…”