Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle

Abstract

There are challenges related to cancer treatment, namely, targeting and biocompatibility associated with a drug vehicle. This research aims to prepare a theranostic cancer vehicle based on porous silica nanoparticles (PSN) with controllable nanoparticle size, supporting targeting properties, and biocompatible. The synthesis method combined the Stöber process and liquid crystal templating using a dispersant and pore expander. Triethanolamine (TEA) and Pluronic F-127 were combined as a steric stabilizer and dispersing agent, while n -hexane was used as a pore expander. The amine functionalization was carried out using the 3-aminopropyl-triethoxysilane solution. Furthermore, radiolabeling of PSN using Iodine-131 and iodogen as oxidizing agents was carried out. The results showed that the best achievable PSN size was 100–150 nm with a polydispersity index of 0.24 using TEA-Pluronic F-127. The functionalization results did not significantly affect the radioiodination result. Radiochemical purity (RCP) values up to 95% were obtained in the radioiodination, while the labeled compounds were relatively stable with 12 mCi radioactivity, indicating the absence of radiolysis. The synthesized PSN was not toxic to normal cell samples up to a concentration of 150 μg/mL for PSN and 170 μg/mL for PSN-NH 2 . The cellular uptake testing results of the PSN- 131 I in cancer cell samples showed promising uptake ability.

Rifampicin adsorption and release study using Santa Barbara amorphous-16 modified Al (SBA-16-Al) for a drug delivery system

“…Previous research has been conducted to study the properties of the MSN nanostructures using small-angle X-ray scattering (SAXS) and one of the applications for radioactive drug delivery. 16,17 From the SAXS characterization study on SBA-16-Al which was carried out previously, it was observed that the synthesized SBA-16-Al is an MSN that has pores in the uniform mesoporous order, a three-dimensional cubic Im 3 m structure, and has a high specific surface area, up to 1000 m 2 g −1 . Mesoporous silica nanomaterial with a high specific surface area and large pore volume will provide a high drug-loading capacity, 18,19 thus lowering the frequency of drug administration.…”

Network Security Protocol Testing Technology Based on Wireless Communication System

“…Regarding NSP testing techniques for WCSs, many scholars at home and abroad have researched and analyzed them.Johannis W reached a preliminary consensus in the important areas of user, data and update management as well as network connectivity and user friendliness, optimizing user management by connecting to directory services and defining access control, combining patient data economy on analyzers with data and data transfer encryption and technically secure communication protocols, update management needs to be defined according to the contract [1].Putra E G R study found that public key algorithms are commonly used to negotiate session keys and authenticate among communicating parties, and then the consensus session keys of the parties are used in a symmetric algorithm for the communication of confidential information [2].…”

In situ carbonization metamorphoses porous silica particles into biodegradable therapeutic carriers of lesser consequence on TGF-β1 mediated fibrosis

“…1 Such qualities make these materials suited for different research and application domains such as drug delivery, impurity extraction, catalysis, sensing etc. [1][2][3][4][5] The production of silica particles in various forms, sizes, and volumes has been achieved by using different synthetic methodologies. 6 Among the many available methods, the mono-dispersity, spherical form, and diameter of the particle can be controlled using the Stöber method.…”

“…The existence of an additional mode could be because of the presence of more low volume pores present on the Si-P-CNP surface which translates into more pores to load drug molecules and added to this, 29 Si NMR spectroscopic investigations revealed an additional level of interaction of curcumin in the Si-P-CNP pores in comparison to the Si-P ones. Spectroscopic study on curcumin loaded Si-P-CNPs (Si-P-CNP-Cur) and curcumin loaded Si-Ps (Si-P-Cur) showed the presence of Q 3 (Si(Osi) 3 OH) and Q 4 (Si(Osi) 4 ) species 27 (Fig. S3, ESI †).…”