Radioiodination and biological evaluation of rabeprazole as a peptic ulcer localization radiotracer

Facile radiolabeling optimization process via design of experiments and an intelligent optimization algorithm: Application for omeprazole radioiodination

“…. The striking decrease in the RY for OMP amount, pH and reaction time may be owing to the occurrence of undesirable side reactions for instance polymerization, chlorination, and denaturation of OMP …”

“…The increase in RY with temperature is owing to the fact that the energy activation barrier is lowered for the reaction at higher temperatures, which leads to improved reaction kinetics.. 30 The striking decrease in the RY for OMP amount, pH and reaction time may be owing to the occurrence of undesirable side reactions for instance polymerization, chlorination, and denaturation of OMP. 31 Even though the main effects gave an obvious idea, the interaction among two parameters would favor a better statement of the radioiodination process by altering from a lower to a higher level without representing nonparallel lines. Figure 2 illustrates the possible negative and positive two-variable interactions amid the variables for RY.…”

Radioiodination and biological evaluation of nizatidine as a new highly selective radiotracer for peptic ulcer disorder detection

“…(Figure A) more than in the case of normal stomach and was confirmed by gamma camera analysis (see Figure ). The published %ID/g ± SD for a number of common of proton pump inhibitors, eg, [ 99m Tc]pantoprazole, [ 99m Tc]omeprazole, [ 99m Tc]rabeprazole, [ 125 I]iodofamotidine, [ 125 I]iodoomeprazole, and [ 131 I]iodorabeprazole, shows a maximum uptake in stomach ulcer of 27.2% ID/g at 30 minutes, 22.0% ID/g at 1 hour, 33.4% ID/g at 30 minutes, 65.9% ID/g at 30 minutes, 47.3% ID/g at 4 hours, and 38.00% at 1 hour, respectively. Our results indicate that iodonizatidine has a higher %ID/g ± SD value than these materials have.…”

“…( Figure 4A) more than in the case of normal stomach and was confirmed by gamma camera analysis (see Figure 3). The published %ID/g ± SD for a number of common of proton pump inhibitors, eg, [ 99m Tc]pantoprazole, 6 9 shows a maximum uptake in stomach ulcer of 27.2% ID/g at…”

“…Nizatidine, dimethyl[(4‐{[(2‐{[1‐(methyl amino)‐2‐nitro ethenyl] amino}ethyl) sulfanyl] methyl}‐1,3‐thiazol‐2‐yl) methyl]amine, is a histamine H 2 ‐receptor antagonist, which can inhibit the production of stomach acid, and is used in the treatment of peptic ulcer disease and gastroesophageal reflux . Many proton pump inhibitors such as [ 99m Tc]pantoprazole, [ 99m Tc]omeprazole, [ 99m Tc]rabeprazole, and [ 125 I]iodorabeprazole have been used to image stomach ulcers. Iodine 123 is the isotope of choice for medical imaging with a half‐life to 13.22 hours and decays by emission of gamma radiation with an energy of 159 keV.…”