Radioimmunodetection of Head and Neck Cancer: A Review

Hopsu, Erkki; Kairemo, Kalevi

doi:10.3109/02841869309096129

Acta Oncologica

1993

DOI: 10.3109/02841869309096129

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Radioimmunodetection of Head and Neck Cancer: A Review

Erkki Hopsu¹,

Kalevi Kairemo²

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1993

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Cited by 5 publications

(1 citation statement)

References 35 publications

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“…Further significance for the identification and characterization of CEA as a biochemical marker lies in the possibility of using this glycoprotein as a diagnostic tool coupled with the other markers, as well as pathological analyses 12 . One example of such a scenario is the use of radiolabeled anti-CEA probe as an additional tool to characterize the tumours 7 (CTL) response 16 or by direct targeting of the cancer cells expressing CEA 9 . The presence of CEA in tumours is therefore gaining significance both from a diagnostic stand point and as an alternate target for cancer therapy.…”

mentioning

confidence: 99%

Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

Pai¹,

Pai²,

Lalitha³

et al. 2006

International Journal of Oral and Maxillofacial Surgery

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mentioning

confidence: 99%

Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

Pai¹,

Pai²,

Lalitha³

et al. 2006

International Journal of Oral and Maxillofacial Surgery

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Correlation of beta-camera imaging and immunohistochemistry in radioimmunotherapy using90Y-labeled monoclonal antibodies in ovarian cancer animal models

et al. 1994

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Tumor stroma contains much fibrin and monoclonal antifibrin antibody targeting is possible in tumors. In this study, nude mouse human ovarian carcinoma xenograft specimens were investigated after treatment with 90Y-labeled monoclonal antifibrin antibody Fab fragment or with 90Y-labeled OC125-monoclonal antibody F(ab')2 fragments. The mice received the radioimmunotherapy activity either intratumorally, intraperitoneally, or intravenously. Beta-camera imaging (BCI) is a novel device for studying activity distribution in tissue specimens and, together with immunohistochemistry (IHC) with OC125, antifibrin, anticarcinoembryonic antigen, anti-cytokeratin, and anti-placental alkaline phosphatase antibodies, was used for correlation of activity distribution of tissue specimens. These results were in concordance: Antigen distribution measured with IHC and radioactivity distribution were similar with the same antibodies, antifibrin, and OC125: However, these antigens demonstrated rather different distribution. Tissue studies revealed that activity was concentrated also in the necrotic tumor tissue, indicating that cell death was also caused by radiation. Differences in the tumor cell morphology were observed using different routes of administration. With BCI, it is possible to quantitate activities in frozen sections (microdosimetry), and these results were in concordance with absolute activities as measured by tissue sampling and well-counting. Three-dimensional reconstruction of tissue slices combined with radioactivity distribution measured with BCI allows estimation of total absorbed radiation dose in tumor after an appropriate dose planning.

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An IgG3-IL2 fusion protein activates complement, binds FcγRI, generates LAK activity and shows enhanced binding to the high affinity IL-2R

Harvill

Morrison

1995

Immunotechnology

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Radioimmunodetection of Head and Neck Cancer: A Review

Cited by 5 publications

References 35 publications

Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

Correlation of beta-camera imaging and immunohistochemistry in radioimmunotherapy using90Y-labeled monoclonal antibodies in ovarian cancer animal models

An IgG3-IL2 fusion protein activates complement, binds FcγRI, generates LAK activity and shows enhanced binding to the high affinity IL-2R

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