Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

Pai, S. Balakrishna; Pai, R; Lalitha, R.M.; Kumaraswamy, S.V.; Lalitha, N.; Johnston, Robert Mackenzie; Bhargava, MK

doi:10.1016/j.ijom.2006.02.012

“…For immunoreactivity studies with c-Myc, 5 μM paraffin sections on glass slides were deparaffinized and processed for studies. Immunohistochemistry was performed using anti-Myc antibodies (Oncor) by standard protocols as described earlier [18]. Counterstaining was done with haematoxylin.…”

Section: Methodsmentioning

confidence: 99%

Overexpression of c-Myc oncoprotein in oral squamous cell carcinoma in the south Indian population

Pai

¹

,

Pai²,

Lalitha³

et al. 2009

ecancer

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Oral neoplasm constitutes a predominant class of cancer that is encountered in South India. This is in large part due to the elevated risk of oncogenesis as a result of the habit of chewing of quids containing betel leaves, areca nut and smokeless tobacco. An array of molecular events are induced during the transformation of the buccal epithelium, among them the over-expression of oncogene products plays a key role. The c-Myc protein, a regulator of a number of key cellular signalling pathways, plays a pivotal role in a number of malignancies. The present study was undertaken to evaluate expression of the c-Myc protein in tumours of the oral cavity from the South Indian population, predominantly oral squamous cell carcinoma (OSCC). The c-Myc protein was over-expressed in 80% of the cases studied. Taking into account the pivotal role demonstrated for c-Myc in tumourigenesis, our observations suggest a key role for Myc oncoprotein in the genesis of OSCC as well as its potential as a therapeutic target in this population.

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“…To the best of our knowledge, this is the first report of a malignant melanoma of the oral cavity which expresses CEA identified by immunohistochemistry. We have recently reported the expression of CEA in OSCC 19 and it is interesting to note that the rare malignant melanoma we studied also share this property.…”

mentioning

confidence: 54%

Identification of Biomarkers in an Oral Malignant Melanoma Case with Potential for Therapeutic Intervention

2010

IJO

0

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A 32-year old female patient presented with the tumor of the oral cavity at the Kidwai Memorial Institute of Oncology, Bangalore, India. Clinical examination and histopathological analyses confirmed the neoplasm as malignant melanoma. This rare melanoma of the buccal mucosa expressed carcinoembryonic antigen (CEA) as well as contained cells that expressed elevated levels of the c-myc oncogene product as identified by immunohistochemistry of the tumor biopsy. Presence of these tumor makers in the rare case of malignant melanoma with poor prognosis should allow exploration of novel targeted therapy against CEA and c-Myc.

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“…We wanted to determine, within the South Indian population, the key tumour markers that are expressed in oral carcinoma that could have prognostic as well as diagnostic implications. Previously, we have reported the expression of carcinoembryonic antigen (CEA) in a number of OSCC from patients from this region [18]. In the present study, we focused on the expression of the c-Myc protein in the oral cancers.…”

Section: Discussionmentioning

confidence: 94%

“…For immunoreactivity studies with c-Myc, 5 µM paraffin sections on glass slides were deparaffinized and processed for studies. Immunohistochemistry was performed using anti-Myc antibodies (Oncor) by standard protocols as described earlier [18]. Counterstaining was done with haematoxylin.…”

Section: Tissue Specimens and Immunohistochemistrymentioning

confidence: 99%

Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma

Pai¹,

Pai²,

Lalitha³

et al. 2009

ecancer

View full text Add to dashboard Cite

Oral neoplasm constitutes a predominant class of cancer that is encountered in South India. This is in large part due to the elevated risk of oncogenesis as a result of the habit of chewing of quids containing betel leaves, areca nut and smokeless tobacco. An array of molecular events are induced during the transformation of the buccal epithelium, among them the over-expression of oncogene products plays a key role. The c-Myc protein, a regulator of a number of key cellular signalling pathways, plays a pivotal role in a number of malignancies. The present study was undertaken to evaluate expression of the c-Myc protein in tumours of the oral cavity from the South Indian population, predominantly oral squamous cell carcinoma (OSCC). The c-Myc protein was over-expressed in 80% of the cases studied. Taking into account the pivotal role demonstrated for c-Myc in tumourigenesis, our observations suggest a key role for Myc oncoprotein in the genesis of OSCC as well as its potential as a therapeutic target in this population.

show abstract

Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

Cited by 4 publications

References 18 publications

Overexpression of c-Myc oncoprotein in oral squamous cell carcinoma in the south Indian population

Overexpression of c-Myc oncoprotein in oral squamous cell carcinoma in the south Indian population

Identification of Biomarkers in an Oral Malignant Melanoma Case with Potential for Therapeutic Intervention

Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma

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