Overexpression of c-Myc oncoprotein in oral squamous cell carcinoma in the south Indian population

Pai, R; Pai, S. Balakrishna; Lalitha, R.M.; Kumaraswamy, S.V.; Lalitha, N.; Johnston, Robert Mackenzie; Bhargava, MK

doi:10.3332/ecancer.2008.128

Cited by 17 publications

(14 citation statements)

References 24 publications

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“…Consistent with the above finding overexpression of p53 in the nuclei of epithelial cells of PHT induced GO tissues have been observed (Saito, 1999). Both the overexpression of mitogenic factors and p53 has been observed in oral dysplastic and precancerous lesions, and has been frequently associated with the development of a wide range of carcinomas including OSCCs (Haque, 1998;Wakulich, 2002;Abbas, 2007;Angiero, 2008;Bishen, 2008;Pai, 2009;). Incidentally, cyclosporine-an immunosuppressant and nifedepine-a calcium channel blocker induce GO and OSCCs have been reported to arise from these tissues as well (Varga, 1991;Pahor, 1996).…”

Section: Introductionsupporting

confidence: 69%

Lack of Mutation in p53 and H-ras Genes in Phenytoin Induced Gingival Overgrowth Suggests its Non Cancerous Nature

Jayaraman¹,

Valiathan²,

Jayakumar³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: There have been case reports of oral squamous cell carcinoma arising from gingival overgrowth induced by phenytoin -an antiepileptic drug. However, a detailed analysis for the presence of mutations in p53 and ras genes, which are the two most frequently mutated genes in cancers, in phenytoin induced gingival overgrowth tissues has hitherto not been performed. Methods: Cellular DNA isolated from twenty gingival overgrowth tissues collected from patients undergoing phenytoin therapy were amplified using primers for p53 (exons 5-8) and H-ras (exons 1-2) genes. The PCR amplicons were then gel purified and subjected to direct sequencing analysis to screen for mutations. Results: Direct sequencing of twenty samples of phenytoin induced gingival growth did not identify mutations in any of the exons of p53 and H-ras genes that were analyzed. Conclusion: Our result indicates that mutational alteration of p53 and H-ras genes is infrequent in phenytoin induced gingival growth, which thus suggests a non malignant nature of this pathology. The findings in the present study are clinically significant as a large number of epileptic patients are treated with phenytoin.

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Section: Introductionsupporting

confidence: 69%

Lack of Mutation in p53 and H-ras Genes in Phenytoin Induced Gingival Overgrowth Suggests its Non Cancerous Nature

Jayaraman¹,

Valiathan²,

Jayakumar³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…c-Myc is a known oncogene, as well as target gene, in various types of cancers, including lung ( 7 – 10 ) and breast cancer ( 10 – 12 ), and hepatocellular carcinoma ( 13 , 14 ). Previous studies showed that the c-Myc protein was overexpressed in 80% of the OSCC ( 15 ), Genome-wide profiling of OSCC has also shown that, among other genes, gain of c-Myc gene occurred at a high frequency ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc

et al. 2018

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Oral squamous cell carcinoma (OSCC) is the predominant histological type of oral cancer. The 5-year survival rate of OSCC is only ~50%. c-Myc is a known oncogene and target gene in various cancer types, including OSCC. The presnet study revealed that c-Myc is one of the target genes of miR-1294. Results indicated lower levels of miR-1294 in OSCC tissues samples collected from 24 patients with OSCC. Notably, overexpression of miR-1294 inhibited proliferation and migration in OSCC cell lines and inhibition of miR-1294 promoted cell growth and migration in OSCC cell lines. Moreover, miR-1294 can target the 3′UTR of c-Myc, as we identified a negative correlation between c-Myc mRNA expression and miR-1294 expression in 24 OSCC tissues. In conclusion, the data demonstrate the tumor suppressive role of miR-1294 in OSCC.

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“…Here, with the help of IHC, attempt has been made to explore the changes in expression of two important molecules related to stemness of the oral stem cells and in this respect the two markers that have been tried are K19, (19), (20), (21), (22) and c-Myc. (23), (24), (25) Though, the expression of K19 and c-Myc on oral dysplasia and oral cancer have been done earlier but, so far, no study has been carried out to look into the expression of these two proteins in the same tissue to characterize the basal stem cells and transient amplifying cells.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Progenitor Cell and Stem Cell Compartments in Normal versus Leukoplakia Affected Oral Mucosa- An Observational Study

Mazumdar¹,

Ghose²,

Hazra³

et al. 2019

jemds

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A B S T R A C T BACKGROUNDOral leukoplakia is a common potentially malignant disorder of the oral cavity which has the propensity to undergo malignant transformation over a period of time. Morphological alterations of the oral mucosa in the form of unscrappable white patch reflect the underlying cellular abnormalities. The available grading systems of epithelial dysplasia do not accurately predict which cases may eventually transform into malignancy. METHODSHere the characterization of stem cell and progenitor cell compartments has been done with the help of Cytokeratin 19 (K19) and c-Myc protein expression by Immunohistochemistry to evaluate the changes in normal non-keratinized oral mucosa and oral leukoplakia in population of Eastern India. RESULTSK19 expression is reduced in oral leukoplakia than normal oral mucosa with a mean value of 16.22±20.69 (Standard Deviation). However, there is no statistically significant change in c-Myc expression with a mean value of 72.66±40.34 (Standard Deviation). CONCLUSIONSThe above study reveals that the expression of K19 is significantly decreased in oral leukoplakia compared to normal oral mucosa. c-Myc expression is showing lower value than in healthy oral mucosa but this difference is not significant statistically.

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Overexpression of c-Myc oncoprotein in oral squamous cell carcinoma in the south Indian population

Cited by 17 publications

References 24 publications

Lack of Mutation in p53 and H-ras Genes in Phenytoin Induced Gingival Overgrowth Suggests its Non Cancerous Nature

Lack of Mutation in p53 and H-ras Genes in Phenytoin Induced Gingival Overgrowth Suggests its Non Cancerous Nature

MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc

Quantitative Analysis of Progenitor Cell and Stem Cell Compartments in Normal versus Leukoplakia Affected Oral Mucosa- An Observational Study

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