Radioimmunoassayable Growth Hormone in the Rat Pituitary Gland: Effects of Age, Sex and Hormonal State

Birge, Clifford A.; Peake, Glenn T.; Mariz, Ida K.; Daughaday, William H.

doi:10.1210/endo-81-2-195

Cited by 219 publications

(77 citation statements)

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“…3). T h e increment in weight age (WA) during the 6 months of H G H treatment (months * SD) was 6 + 6.8, which was significantly less ( P < 0.001) than the WA increment observed during H G H and androgen treatment (21 4 …”

Section: Rate Of Weight Gainmentioning

confidence: 87%

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Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

1974

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ExtractTwelve hypopituitary patients ranging in age from 58f2 to 15 ?fa years were treated for 12 months with a standardized dose of human growth hormone (HGH), 0.1 or 0.05 U/kg three times weekly). From the 7th to 12th month inclusive, fluoxymesterone, 2.5 mg/m2/24 hr per os was given in combination with the growth hormone. From the 12th to the 18th month, no therapy was given. Heights and weights were recorded every 1 or 2 months. Bone age films were assessed at the onset and again in the 6th, 12th, and 18th month of the study.In the first 6 months of HGH therapy, the mean growth rate (centimeters per year f SD) was 9.4 =t 2.3. During combined treatment with HGH and fluoxymesterone, the mean growth rate of 13.4 f 3 was significantly greater ( P < 0.001) than on HGH alone. Post-treatment mean growth rate from the 13th through 18th month, inclusive, was 2.7 =t 1.2. Weight gain (kilograms per year & SD) during combined treatment (13 =t 7) was significantly greater ( P < 0.001) than during HGH administration (3.4 =t 2.4). Mean advancement in bone maturation (months =t SD) during HGH (12 f 7.7) was not significantly different from the mean gain in bone age during combined treatment (12 =t 12). In the final 6 months without any therapy, the mean gain in bone age was 8.8 f 6.1. In the 18 months of study, the mean increase in bone age was 33 months, and the mean gain in height age (HA) was 23 months.Although final evaluation of this treatment program depends upon a longer period of observation, the immediate assessment suggests that the significant improvements in height, weight, and physical appearance were sufficient to compensate for the gains in bone maturation, especially since the patients who entered the study had markedly retarded bone ages. SpeculationHGH and androgens interact synergistically. Androgens stimulate HGH secretion in intact animals. In the hypopituitary state, androgens require the addition of HGH for optimal promotion of optimal growth and secondary sexual development.

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Section: Rate Of Weight Gainmentioning

confidence: 87%

“…Studies carried out in intact animals and humans have shown that androgens increase the pituitary content [4] and enhance pituitary secretion of growth hormone [IO]. In hypopituitary animals [13, 151 and humans [7,11,171, the maximal growth promoting effects of androgens are dependent upon the simultaneous administration of growth hormone.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

1974

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“…Le taux sérique de GH est fortement diminué (Kaplan et al, 1972 ;Grumbach et Kaplan, 1973 (Kaplan et al, 1972(Kaplan et al, , 1976 (Gluckman et al, 1979a, b). Chez le Rat, le contenu hypophysaire s'accroît pendant la vie foetale et jusqu'à l'âge de 20 jours (Birge et a/., 1967 ;Rieutort, 1974 ;Walker et al, 1977). Le taux plasmatique s'élève jusqu'au pic observé au moment de la naissance pour décroître ensuite dans les dix premiers jours avant de se stabiliser (Rieutort, 1974 ;Blazquez et al, 1974 ;Strosser et Mialhe, 1975 (Cella et al, 1985).…”

Section: Introductionunclassified

Ontogenèse des hormones de l'axe somatotrope

Dubois¹,

Hemming²

1987

Reprod. Nutr. Dévelop.

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“…Some evidence suggests that age, endocrine status, and genetic factors may influence the responsiveness of animal and human subjects to growth hormone (GH):' (a) The pituitary glands of adult rats contain as much GH as those of young rats (1). Heins, Garland, and Daughaday (2) found that the in vitro responsiveness of the rat's costal cartilage to "sulfation factor" diminishes with age of the animal.…”

Section: Introductionmentioning

confidence: 99%

Observations on the responsiveness of human subjects to human growth hormone

Rudman¹,

Chyatte²,

Patterson³

et al. 1971

J. Clin. Invest.

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A B S T R A C T The effect of human growth hormone (HGH) on the N, P, Na, and K balance, and on the body weight (BW) of three groups of subjects was measured. In group I were nine cases (age 6-69) with HGH deficiency; in group II, eight cases (age 9-79) with normal endogenous HGH; in group III, four cases with myotonic dystrophy (age 45-51). After a 7 day control period, the hormone was administered for 7 days. Each subject was tested with three doses of HGH: dose A, 0.0168 U/kg BW"' per day; dose B, 0.0532 U/kg BW3'4 per day; dose C, 0.168 U/kg BW314 per day.In group I, the responsiveness to HGH declined with age. Two subjects aged 6 yr responded to all three doses of HGH with positive balances in N, P, Na, and K and increases in BW. At ages 15-17, responses were obtained only to doses B and C in three cases, and only to dose C in two cases. Two subjects, aged 42 and 69, responded only to dose C. Not only did the threshold dose increase with age in group I, but the magnitude of the responses declined with age as well.Patients of group II were less responsive to all doses of HGH than were patients of group I at comparable age. None responded to dose A or dose B. All responded to dose C, but the increments in balances and in BW stimulated by this dose were only one-third to one-half as great as in HGH-deficient subjects of similar age.Three patients of group III responded to all three doses of HGH, and one responded to doses B and C. The responses were similar in magnitude to those in the

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Radioimmunoassayable Growth Hormone in the Rat Pituitary Gland: Effects of Age, Sex and Hormonal State

Cited by 219 publications

References 0 publications

Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

Ontogenèse des hormones de l'axe somatotrope

Observations on the responsiveness of human subjects to human growth hormone

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