Radioimmunoassay for the quantitative determination of hesperidin and analysis of its distribution in Citrus sinensis

Barthe, G. A.; Jourdan, Pablo; McIntosh, Cecilia A.; Mansell, Richard L.

doi:10.1016/0031-9422(88)80625-3

Cited by 43 publications

(30 citation statements)

References 6 publications

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“…It has been isolated at large scale from the rinds of paradisi Macfad., Citrus sinensis (L.) Osbeck, and Citrus unshiu Marcovitch. (Barthe et al, 1988;Inoue et al, 2010;Rouseff et al, 1987). It has also been reported from other Citrus species such as Citrus aurantium L. var.…”

Section: Food Sourcesmentioning

confidence: 85%

Hesperidin: A promising anticancer agent from nature

Devi

Rajavel

Nabavi

et al. 2015

Industrial Crops and Products

125

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Section: Food Sourcesmentioning

confidence: 85%

Hesperidin: A promising anticancer agent from nature

Devi

Rajavel

Nabavi

et al. 2015

Industrial Crops and Products

125

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“…This indicated that conditions leading to organogenesis also led to increased production of flavanone glycosides. The high sensitivity of the radioimmunoassay used for naringin and hesperidin (Jourdan et al 1985;Barthe et al 1987Barthe et al , 1988) allowed for their identification in callus cultures while previous TLC methods were not able to detect these compounds in cell cultures (Lewinsohn et al 1986(Lewinsohn et al , 1989a. The ability of detached young grapefruit to make naringin and prunin when fed 14 C-acetate and 14 C-phenylalanine demonstrated that both compounds could be synthesized in vitro (Berhow and Vandercook 1989).…”

Section: Citrus Gt Enzymologymentioning

confidence: 95%

“…Therefore, it should come as no surprise that several groups were working on the production of flavanone diglycosides in cell cultures and during plant regeneration (refs: e.g., Lewinsohn et al 1986;Barthe et al 1987;Barthe et al 1988;Mansell and McIntosh 1991). In 1986, Lewinsohn et al demonstrated that Citrus paradisi cell cultures were capable of glucosylating exogenous naringenin and hesperitin resulting in the production of prunin (naringenin-7-Oglucoside) and hesperitin-7-O-glucoside, respectively.…”

Section: Citrus Gt Enzymologymentioning

confidence: 97%

Advances in flavonoid glycosyltransferase research: integrating recent findings with long-term citrus studies

McIntosh

Owens

2016

Phytochem Rev

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Flavonoid glycosides are required for a number of crucial roles in planta and have the potential for development in a variety of agricultural, medicinal, and biotechnological applications. A number of recent advancements have been made in characterizing glycosyltransferases, the enzymes that are responsible for the synthesis of these important molecules. In this review, glycosyltransferases are considered with regard to biochemical properties, expression patterns, levels of enzyme activity during development, and structure/function relationships. This is presented with historical context to highlight critical findings, particularly with regard to the innovative work that has come from research on citrus species. The plant glycosyltransferase crystal structures that have been solved over the past decade, either alone or in complex with sugar donor and/or acceptor molecules, are discussed. The application of results from these structures to inform current structure/function work as well as implications and goals for future crystallography and tertiary modeling studies are considered. A thorough understanding of the properties of glycosyltransferases will be a critical step in any future biotechnological application of these enzymes in areas such as crop improvement and custom design of enzymes to produce desired compounds for nutritional and/or medicinal usage.

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“…Among flavonoids, the flavanone hesperidin is the major flavonoid present in citrus fruits such as sweet oranges and lemons (Brand et al, 2008;Bredsdorff et al, 2010;González-Barrio et al, 2004). In immature oranges, the amount of hesperidin may make up to 14% of the fresh weight of the fruit (Barthe, Jourdan, McIntosh, & Mansell, 1988). Hesperidin is structurally a flavanone b-glycosides at C-7 of hesperetin aglycone, which is 3 0 ,5,7-trihydroxy-4 0 -methoxy flavanone.…”

Section: Introductionmentioning

confidence: 99%