Hesperidin: A promising anticancer agent from nature

Devi, Kasi Pandima; Rajavel, Tamilselvam; Nabavi, Seyed Fazel; Setzer, William N.; Ahmadi, Amirhossein; Mansouri, Kowsar

doi:10.1016/j.indcrop.2015.07.051

Cited by 116 publications

(58 citation statements)

References 75 publications

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“…Hesperidin possesses vitamin‐like activity and can decrease capillary permeability (vitamin P), leakiness and fragility . It also showed anti‐oxidant, anti‐inflammatory, anti‐carcinogenic and anti‐allergic properties …”

Section: Resultscontrasting

confidence: 76%

“…32 It also showed anti-oxidant, anti-inflammatory, anti-carcinogenic and anti-allergic properties. [32][33][34] wileyonlinelibrary.com/jsfa The third and fourth most common compounds in the accessions studied were epicatechin (34% of accessions) and kaempferol 3-O-glucoside (30% of accessions). High levels of epicatechin were found in accession #115 (0.055 g kg −1 ) whereas kaempferol-3-O-glucoside was found in accessions #4, #24 #56, #102 #114 and #146 (0.013 to 0.034 g kg −1 ).…”

Section: Characterization Of Phenolic and Flavonoid Compoundsmentioning

confidence: 99%

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Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

et al. 2019

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BACKGROUND The Cerrado occupies 23% of Brazil. A. othonianum is a native Cerrado species that presents differently colored pseudofruits. This report describes the morphometric properties, physicochemical characterization, and phenolic and flavonoid compound compositions of 30 accessions of A. othonianum. RESULTS The morphometric properties show that an average fruit had 21.97 mm length, 18.61 mm width, and 11.13 mm thickness, with 2.52 g mass. The pseudofruits had 28.84 mm apex width with 12.83 g of mass. The hue parameters of the pseudofruits were 18.67 ± 2.00 and 83.32 ± 1.97° (P < 0.05), reflecting their red to yellow color. The titratable acidity of the accessions was 0.91 ± 0.09 to 3.02 ± 0.02% (P < 0.05), soluble solid content was 9.60 ± 0.17 to 13.47 ± 0.38 °Brix (P < 0.05), and pH ranged from 2.83 ± 0.06 to 3.83 ± 0.06 (P < 0.05). Fourteen flavonoid compounds were identified. The most common compounds in the accessions were vitexin (93% of the accessions), hesperidin (57% of the accessions), epicatechin (34% of the accessions), and kaempferol‐3‐O‐glucoside (30% of the accessions). Cluster analysis generated four groups with the traits ΔE, °h, C, soluble solid content, titratable acidity, pH, total flavonoids, and their identified compounds. CONCLUSIONS Although all accessions are A. othonianum, there the chemical composition and the physical characteristics of these fruits vary. This is the first report in the literature using wild accessions. Greater disclosure of the species characteristic is interesting because it can increase income for the local population. © 2019 Society of Chemical Industry

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Section: Resultscontrasting

confidence: 76%

Section: Characterization Of Phenolic and Flavonoid Compoundsmentioning

confidence: 99%

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

et al. 2019

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“…In a phase clinical study conducted on healthy human subjects (18–75 years old) in three independent investigations using different amounts of orange juice supplemented with hesperidin, hesperidin‐containing orange juice was found to modulate postprandial blood glucose levels by partially inhibiting intestinal GLUTs (Kerimi et al, ). Also, this compound was shown cytotoxicity toward various types of human cancer cells and other evidences of potential antitumor activity, as summarized in a previous review (Devi et al, ).…”

Section: Flavonoid Glucose Transport Inhibitorsmentioning

confidence: 81%

“…As reviewed previously, hesperidin ( 13 ) showed potential antitumor efficacy (Devi et al, ). In a phase clinical study conducted on healthy human subjects (18–75 years old) in three independent investigations using different amounts of orange juice supplemented with hesperidin, hesperidin‐containing orange juice was found to modulate postprandial blood glucose levels by partially inhibiting intestinal GLUTs (Kerimi et al, ).…”

Section: Flavonoid Glucose Transport Inhibitorsmentioning

confidence: 84%

Plant‐derived glucose transport inhibitors with potential antitumor activity

Shriwas

Chen

Kinghorn

et al. 2019

Phytotherapy Research

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Glucose, a key nutrient utilized by human cells to provide cellular energy and a carbon source for biomass synthesis, is internalized in cells via glucose transporters that regulate glucose homeostasis throughout the human body. Glucose transporters have been used as important targets for the discovery of new drugs to treat cancer, diabetes, and heart disease, owing to their abnormal expression during these disease conditions. Thus far, several glucose transport inhibitors have been used in clinical trials, and increasing numbers of natural products have been characterized as potential anticancer agents targeting glucose transport. The present review focuses on natural product glucose transport inhibitors of plant origin, including alkaloids, flavonoids and other phenolic compounds, and isoprenoids, with their potential antitumor properties also discussed.

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“…By report, several methods have been applied for extracting EOs, namely steam distillation (SD) and supercritical fluid extraction-CO 2 (SFE-CO 2 ), and SD as the common method is recorded on Chinese pharmacopeia, while several studies have quantified flavonoids in Citrus herbs using thin-layer chromatography (TLC), HPLC-UV, HPLC-DAD, HPLC-ECD, HPLC-MS, and CE-ECD, primarily focusing on the determination of flavonoids in fruits, juices, or CRP of different Citrus species (Camarda, Di Stefano, Del Bosco, & Schillaci, 2007;Careri, Elviri, Mangia, & Musci, 2000;Liu et al, 2013;Peng, Liu, & Ye, 2006;Sahraoui et al, 2011;Wang & Luo, 1989;Zheng et al, 2009). In recent studies, lots of attention is being paid to flavonoids because of its anticancer, antioxidant, anticonvulsant, and anti-inflammatory properties (Chang et al, 2015;Devi et al, 2015;Dimpfel, 2006;Fu et al, 2017), whereas few on volatile oils which have abundantly valid biological activities on CRP (Duan et al, 2016;Yi, Dong, Liu, Yi, & Zhang, 2015). So far, there were a group of analyses of flavonoids including constituents and contents, and the results indicated obvious differences in CP and GCP (Lin, Li, Ho, & Lo, 2012;Liu et al, 2013;Xing, Zhao, Zhang, & Li, 2017;Zhang et al, 2012;Zheng et al, 2009Zheng et al, , 2013.…”

mentioning

confidence: 99%

Evaluation of chemical components in Citri Reticulatae Pericarpium of different cultivars collected from different regions by GC–MS and HPLC

Luo

et al. 2017

Food Science & Nutrition

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To discriminate the feasible differences and find potential similarities and relationships of Citri Reticulatae Pericarpium (CRP), this work was accomplished by a comprehensive and reliable method using gas chromatography–mass spectrometer (GC–MS) to analyze the volatile oils and high‐performance liquid chromatography (HPLC) simultaneously to determine the contents of five bioactive flavonoids, namely hesperidin, nobiletin, 3,5,6,7,8,3′,4′‐heptamethoxyflavone, tangeretin, and 5‐hydroxy‐6,7,8,3′,4′‐pentamethoxyflavone in 25 batches of CRP samples of 10 cultivars collected from different regions in China. The GC–MS analyses indicated that 98 compounds were successfully identified from the volatile oils obtained and the major constituents of volatile oil are d‐limonene, γ‐terpinene, α‐pinene, linalool, and myrcene. Even 2‐(methylamino) benzoate was found in all cultivar samples harvested at maturation stage. Under the optimal condition, the quantitative analyses of five bioactive flavonoids were successfully performed by HPLC and hierarchical cluster analysis (HCA). Results showed significant differences among cultivars in the contents of five bioactive flavonoids mentioned earlier. The HCA and GC–MS results provided a convenient approach which might be applied for rapid similarity evaluation and also holds the potential for analysis of compounds present in other plants. Therefore, this work obtained offers scientific basis to control quality and develop medicinal value of the medicinal materials in CRP.

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Hesperidin: A promising anticancer agent from nature

Cited by 116 publications

References 75 publications

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

Physicochemical characterization of ‘Cerrado’ cashew (Anacardium othonianum Rizzini) fruits and pseudofruits

Plant‐derived glucose transport inhibitors with potential antitumor activity

Evaluation of chemical components in Citri Reticulatae Pericarpium of different cultivars collected from different regions by GC–MS and HPLC

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