Radiographic progression in rheumatoid arthritis: A long-term rospective study of 109 patients

Graudal, Niels; Jurik, Anne Grethe; Garvalho, Anselmo de; Graudal, H

doi:10.1002/1529-0131(199808)41:8<1470::aid-art18>3.0.co;2-v

Cited by 61 publications

(34 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a substantial portion of patients exhibit a sustained rate of joint destruction along several years (20,21). In fact, the very purpose of the present study was to assess the additional prognostic value of the autoantibodies in patients with a well-established diagnosis of RA and for this purpose the selected sample seemed to be the most appropriate.…”

Section: Discussionmentioning

confidence: 98%

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Nieto-Colonia

Santos

Keusseyan

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Nieto-Colonia

Santos

Keusseyan

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

“…However, Larsen score was recently used to show that the progress of bone damage in RA follows a mathematical function of time for up to 30 years after disease onset (35).…”

Section: Discussionmentioning

confidence: 99%

Association of interleukin‐4 and interleukin‐1B gene variants with Larsen score progression in rheumatoid arthritis

Genevay¹,

Giovine²,

Perneger³

et al. 2002

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To perform a genetic association study using markers in the interleukin-1 (IL-1) gene cluster and the IL-4/IL-4 receptor system genes, seeking evidence for involvement in the onset or the erosive outcome of rheumatoid arthritis (RA). Methods. We tested the allelic distribution of IL-1A (؉4845), IL-1B (؊511), IL-1B (؉3954), IL-1RN (؉2018), IL-4 variable number of tandem repeat (VNTR), and IL-4R (؉1902) in 233 patients with RA, 99 with polymyalgia rheumatica, and 148 ethnically matched controls. We analyzed the frequency of these gene variants in respect to presence of disease, but also to the degree of radiologic erosions (Larsen score) as a function of disease duration in 157 patients who had available radiographs of both hands. Results. None of the 6 genetic polymorphisms was significantly different in frequency between RA patients and healthy controls or patients with polymyalgia rheumatica. Among RA patients, the rarer (#2) alleles of IL-4 VNTR and IL-1B (؊511) were both associated with a milder Larsen score progression: The slope of Larsen progression in the rare allele groups diverged significantly from those of the frequent allele groups after approximately 20 years of disease duration (P < 0.001). Conclusion. None of the markers tested were shown to be associated with increased or decreased risk of RA. The rarer alleles of IL-4 VNTR and IL-1B (؊511) appear to be associated with a less severe course in RA of long duration.

show abstract

“…Only definite erosive changes corresponding to grades 2-5 were considered when calculating the R score (maximum score 19×5=95). A radiographic outcome event was defined as the occurrence of at least 10% (RE10), 20% (RE20), 30% (RE30), and 40% (RE40) of maximal radiographic score (scores 10, 19, 29, and 38 of 95) 33 during the observation period of up to 43 years.…”

Section: Frommentioning

confidence: 99%

Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome

Svenson²,

Tarp³

et al. 2002

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Radiographic progression in rheumatoid arthritis: A long-term rospective study of 109 patients

Abstract: The progression of radiographic damage in RA followed mathematical functions of time. The identification of progression type may be used in the prediction of outcome in patients with RA.

Cited by 61 publications

References 10 publications

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis

Association of interleukin‐4 and interleukin‐1B gene variants with Larsen score progression in rheumatoid arthritis

Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome

Contact Info

Product

Resources

About