Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome

Na, Graudal; Svenson, M; Tarp, Ulrik; Garred, Peter; Ag, Jurik; Bendtzen, Klaus

doi:10.1136/ard.61.7.598

Cited by 56 publications

(39 citation statements)

References 41 publications

(34 reference statements)

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“…This includes the observation that levels of membrane-bound IL-1a, but not serum IL-1a or IL-1b, correlate with the severity of arthritis in a mouse model, 37 and that RA patients producing anti-IL-1a antibodies develop a less destructive disease. 38 Dysregulation of the IL1A gene could lead to a perpetuation of the local inflammatory process, contributing to the development of a chronic inflammatory state. IL1RN encodes the IL-1 receptor antagonist IL-1Ra, alterations in the expression of this gene could lead to decreased levels of IL-1 antagonism, resulting in enhanced IL-1 cell signalling.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis

et al. 2008

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Patients with systemic juvenile idiopathic arthritis (sJIA) have a characteristic daily spiking fever and elevated levels of inflammatory cytokines. Members of the interleukin-1 (IL-1) gene family have been implicated in various inflammatory and autoimmune diseases, and treatment with the IL-1 receptor antagonist, Anakinra, shows remarkable improvement in some patients. This work describes the most comprehensive investigation to date of the involvement of the IL-1 gene family in sJIA. A two-stage case-control association study was performed to investigate the two clusters of IL-1 family genes using a tagging single nucleotide polymorphism (SNP) approach. Genotyping data of 130 sJIA patients and 151 controls from stage 1 highlighted eight SNPs in the IL1 ligand cluster region and two SNPs in the IL1 receptor cluster region as showing a significant frequency difference between the populations. These 10 SNPs were typed in an additional 105 sJIA patients and 184 controls in stage 2. Meta-analysis of the genotypes from both stages showed that three IL1 ligand cluster SNPs (rs6712572, rs2071374 and rs1688075) and one IL1 receptor cluster SNP (rs12712122) show evidence of significant association with sJIA. These results indicate that there may be aberrant control of the activity of the IL-1 family in sJIA patients causing the increased susceptibility to the disease.

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Section: Discussionmentioning

confidence: 99%

Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis

et al. 2008

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“…The lowest value for a positive outcome was set to >20 U. Anti-IL1a were analysed by radioimmunoassay as described previously. 37 The limit for positive results for anti-IL1a was defined as a binding of .10%.…”

Section: Radiographic Evaluationmentioning

confidence: 99%

“…32 33 It has been shown that patients with arthritis who carry the anti-IL1a develop less destructive disease. [34][35][36][37] The reported frequency of anti-IL1a in the population varies from 10% to 60%, depending on age, sex, and assay sensitivity. 38 Genetic predictors for rheumatoid arthritis, mainly the HLA-DRB1 alleles, have been investigated but the results are inconsistent in relation to prognosis for joint damage, disability, and disease persistence.…”

mentioning

confidence: 99%

Prognostic laboratory markers of joint damage in rheumatoid arthritis

Lindqvist

Eberhardt²,

Bendtzen³

et al. 2005

Annals of the Rheumatic Diseases

310

173

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Objective: To investigate whether determination of a set of laboratory markers at baseline provides prognostic information on joint damage in hands and feet in rheumatoid arthritis. Methods: 183 patients with early rheumatoid arthritis included in a prospective study were examined. Radiographic changes in hands and feet at 5 and 10 years after inclusion were evaluated (Larsen). The markers analysed were: erythrocyte sedimentation rate (ESR); HLA-DRB alleles typed by restriction fragment length polymorphism; and C reactive protein, cartilage oligomeric matrix protein (COMP), rheumatoid factor (RF) (IgG, IgA, and IgM subtypes), antibodies against cyclic citrullinated peptide (anti-CCP), and antibodies against interleukin 1a (anti-IL1a), analysed by immunoassays. Multiple linear regression with backward elimination was used to determine the prognostic value of the variables. Results: 117/176 patients were positive for IgG RF, 138/176 for IgA RF, 139/176 for IgM RF, 140/176 for anti-CCP, and 40/182 for anti-IL1a. After five years, ESR, the presence of IgA RF, serum COMP, and the presence of anti-CCP were significantly associated with more severe joint damage, and the presence of anti-IL1a with less severe joint damage. Baseline C reactive protein and anti-CCP predicted radiographic outcome after 10 years. A stronger prediction was obtained by combining the prognostic factors. Conclusions: Early determination of anti-CCP, IgA RF, anti-IL-1a, ESR, C reactive protein, and COMP predicted the development of joint damage in hands and feet in this cohort. A combination of these measures reflecting different aspects of the disease process should be useful for evaluating prognosis in individual patients with early rheumatoid arthritis.

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“…The objective is to develop methods with sensitivity and specifi city for earlier RA diagnosis, more reliable activity markers, and prognostic indicators. Some of the autoantibodies used in RA investigation are as follows: mutated citrullinated vimentin antibodies (anti-MCV); [49][50][51] antikeratin antibodies (AKA); anti-perinuclear factor (APF); 52 antifi laggrin autoantibodies; 53 anti-human citrullinated fi brinogen antibodies (ACF); 54 anti-heterogeneous nuclear ribonucleoprotein A2 autoantibody (anti-RA33); 52 anti-interleukin 1 antibody (anti-IL1); 55 anti-alpha-enolase antibody; 56 and anti-advanced glycation end-products antibody. 57 These antibodies have, in general, good specifi city, but sensitivity lower than that of anti-CCP for diagnosing RA.…”

Section: Other Antibodiesmentioning

confidence: 99%

Consenso da Sociedade Brasileira de Reumatologia 2011 para o diagnóstico e avaliação inicial da artrite reumatoide

Mota¹,

Cruz²,

Brenol³

et al. 2011

Rev. Bras. Reumatol.

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Autoantibodies against interleukin 1alpha in rheumatoid arthritis: association with long term radiographic outcome

Cited by 56 publications

References 41 publications

Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis

Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis

Prognostic laboratory markers of joint damage in rheumatoid arthritis

Consenso da Sociedade Brasileira de Reumatologia 2011 para o diagnóstico e avaliação inicial da artrite reumatoide

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