Radiographic lung density assessed by computed tomography is associated with extravascular lung water content

Abstract

In ovine oleic acid-induced ALI, lung tissue volume, as assessed by quantitative CT, is in close agreement with EVLWI, as determined by indicator dilution methods and postmortem gravimetry, but overestimates lung fluid content.

Resolution of pulmonary edema with variable mechanical ventilation in a porcine model of acute lung injury

“…The significant decrease in global lung density further supports this conclusion. Scillia et al 20 revealed a significant correlation between CT derived density and EVLW by means of double indicator dilution in a canine OA model; this was confirmed later by Kuzkov et al 21 The single indicator thermodilution determination of EVLW has been validated clinically against the double indicator dilution method 16,22 and has been substantiated in animal studies against gravimetry. [23][24][25] As the PiCCO calculation of EVLW excludes both blood and tissue volumes, we anticipated lower PiCCO derived EVLW values compared with CT determined lung weights, but we expected EVLW to increase as CT lung weight increased with OA injury.…”

The Relationship between the Plasma Triglyceride Concentration and the Severity of Acute Respiratory Distress Syndrome

“…Сердечный индекс является важнейшей детерминантой транспорта кисло рода и коррелирует с тяжестью органной дисфункции. В то время как введение экзогенных жиров может напря мую угнетать сократимость миокарда [12], хроническое повышение концентрации ТГ является важным факто ром риска сердечно сосудистых заболеваний [22].…”

“…Экспериментальные исследова ния подтверждают, что ОПЛ ведет к подавлению мета болизма липидов клетками эндотелия легочных сосудов [11]. С другой стороны, хорошо известно повреждающее действие экзогенных жиров на ткань легких, что широко используется в эксперименте для воспроизведения мо дели обратимого острого повреждения легких при помо щи олеиновой кислоты [12].Цель исследования -изучить взаимосвязь плаз менной концентрации триглицеридов с клиническим ис Triglycerides (TG) may be involved in the pathogenesis of critical impairments. Objective: to study the relationship between the plasma concentration of TG, the outcome of the disease, and the markers of its severity in intensive care unit patients with early stage acute respiratory distress syndrome (ARDS).…”

“…Экспериментальные исследова ния подтверждают, что ОПЛ ведет к подавлению мета болизма липидов клетками эндотелия легочных сосудов [11]. С другой стороны, хорошо известно повреждающее действие экзогенных жиров на ткань легких, что широко используется в эксперименте для воспроизведения мо дели обратимого острого повреждения легких при помо щи олеиновой кислоты [12].…”

Quantitative analysis of pulmonary pathophysiology using postmortem computed tomography with regard to the cause of death

“…Full utilization of the potential of the diagnostic imaging procedure is expected to obtain evidence that cannot be detected by conventional autopsy [5,14]. Lung structures are relatively well demonstrated by CT, and radiological transparency depends on the air contents involved in respiratory function; thus, quantitative analyses of air contents and distribution are used for clinical evaluation of airway structures in the diagnosis of pulmonary emphysema [15,16], and pulmonary congestion and edema [13,15,[17][18][19][20][21][22][23]. Since opening the thorax at autopsy inevitably interferes with the status of the lungs and pleural spaces, non-invasive CT examination is expected to provide indispensable information to investigate pulmonary pathology despite postmortem interference [10,24]; however, there appears to have been no quantitative study of postmortem CT data of the lung with regard to cardiopulmonary function in the death process.…”